Results 71 to 80 of about 76,481 (272)
Image_2_B Cells Adapt Their Nuclear Morphology to Organize the Immune Synapse and Facilitate Antigen Extraction.tif [PDF]
, 2022 Upon interaction with immobilized antigens, B cells form an immune synapse where actin remodeling and re-positioning of the microtubule-organizing center (MTOC) together with lysosomes can facilitate antigen extraction.
Jorge Jara-Wilde (10699137) +10 more
core +1 more source
The dendritic cell synapse: a life dedicated to T cell activation
Frontiers in Immunology, 2016 T cell activation within immunological synapses is a complex process whereby different types of signals are transmitted from antigen presenting cells to T cells.
Federica eBenvenuti
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
Image_6_Proteasome Dependent Actin Remodeling Facilitates Antigen Extraction at the Immune Synapse of B Cells.TIF [PDF]
, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Felipe Del Valle Batalla (6373913) +4 more
core +1 more source
PLoS ONE, 2013 CD28, CTLA-4 and PD-L1, the three identified ligands for CD80/86, are pivotal positive and negative costimulatory molecules that, among other functions, control T cell motility and formation of immune synapse between T cells and antigen-presenting cells (
Nahzli Dilek +9 more
doaj +1 more source
Uncovering G Protein‐Coupled Receptors: Novel Targets and Biomarkers for Predicting Glioma Prognosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Low‐grade gliomas (LGG) exhibit significant heterogeneity and recurrence risk. G protein‐coupled receptors (GPCR) contribute to glioma malignant progression, but their prognostic value remains unclear. This work attempts to formulate a GPCR‐based outcome‐predicting model for LGG. Methods Based on TCGA LGG data, the enrichment scores
Jun Yang +4 more
wiley +1 more source
The role of complement in synaptic degeneration [PDF]
, 2012 Synapse loss is an early event of many neurodegenerative diseases including Alzheimer?s disease and Parkinson?s disease. The causes and mechanisms that underpin synapse dysfunction and degeneration are poorly understood.
Malfa, Katya
core
Imaging the Immune synapse [PDF]
, 2023 Trabajo presentado en IIBM Retreat, celebrado en Miraflores de la Sierra (España) del 13 al 14 de junio de 2023.Immune synapse (IS) formation by T lymphocytes constitutes a crucial event involved in antigen-specific, cellular and humoral immune responses.
Izquierdo, Manuel
core
Frontiers in Immunology, 2015 Tumours can escape immune destruction through the development of antigen loss variants and loss of antigen processing/presentation pathways thereby rendering them invisible to T cells.
Marian eNassef Kadry Naguib Roufaiel +2 more
doaj +1 more source
Time-dependent and selective microglia-mediated removal of spinal synapses in neuropathic pain
Cell Reports, 2023 Summary: Neuropathic pain is a debilitating condition resulting from damage to the nervous system. Imbalance of spinal excitation and inhibition has been proposed to contribute to neuropathic pain.
Noosha Yousefpour +9 more
doaj +1 more source