Results 91 to 100 of about 1,284,834 (277)

The Immune Checkpoint Protein PD-L1 Regulates Ciliogenesis and Hedgehog Signaling

Cells
The primary cilium, an antenna-like sensory organelle that protrudes from the surface of most eukaryotic cell types, has become a signaling hub of growing interest given that defects in its structure and/or function are associated with human diseases and
Ewud Agborbesong, Xiaogang Li
doaj   +1 more source

The Rap1-cofilin pathway coordinates actin reorganization and MTOC polarization at the B-cell immune synapse

, 2017
B cells that bind antigens displayed on antigen-presenting cells (APCs) form an immune synapse, a polarized cellular structure that optimizes the dual functions of the B-cell receptor (BCR), signal transduction and antigen internalization. Immune synapse
Jia C. Wang, Sonja Christian, Caitlin Pritchard, Jeff Y.-J. Lee, May Dang-Lawson, Spencer A. Freeman, Michael R. Gold   +6 more
core   +1 more source

The ciliary machinery is repurposed for T cell immune synapse trafficking of LCK [PDF]

, 2018
Upon engagement of the T cell receptor with an antigen-presenting cell, LCK initiates TCR signaling by phosphorylating its activation motifs. However, the mechanism of LCK activation specifically at the immune synapse is a major question.
Stephen, Louise A., Castro Sanchez, Patricia, McIlwraith, Michael J, Ismail, Shehab, McIlwraith, Michael J., Yelland, Tamas, Roda-Navarro, Pedro, Stephen, Louise A, ElMaghloob, Yasmin   +8 more
core   +1 more source

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Overcoming CD226-related immune evasion in acute myeloid leukemia with CD38 CAR-engineered NK cells

Cell Reports
Summary: CD226 plays a vital role in natural killer (NK) cell cytotoxicity, interacting with its ligands CD112 and CD155 to initiate immune synapse formation, primarily through leukocyte function-associated-1 (LFA-1). Our study examined the role of CD226
Luciana Melo Garcia, Achintyan Gangadharan, Pinaki Banerjee, Ye Li, Andy G.X. Zeng, Hind Rafei, Paul Lin, Bijender Kumar, Sunil Acharya, May Daher, Luis Muniz-Feliciano, Gary M. Deyter, Gabriel Dominguez, Jeong Min Park, Francia Reyes Silva, Ana Karen Nunez Cortes, Rafet Basar, Nadima Uprety, Mayra Shanley, Mecit Kaplan, Enli Liu, Elizabeth J. Shpall, Katayoun Rezvani   +22 more
doaj   +1 more source

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

eLife, 2019
Planar supported lipid bilayers (PSLB) presenting T cell receptor (TCR) ligands and ICAM-1 induce budding of extracellular microvesicles enriched in functional TCR, defined here as synaptic ectosomes (SE), from helper T cells.
David G Saliba, Pablo F Céspedes-Donoso, Štefan Bálint, Ewoud B Compeer, Kseniya Korobchevskaya, Salvatore Valvo, Viveka Mayya, Audun Kvalvaag, Yanchun Peng, Tao Dong, Maria-Laura Tognoli, Eric O'Neill, Sarah Bonham, Roman Fischer, Benedikt M Kessler, Michael L Dustin   +15 more
doaj   +1 more source

Diacylglycerol kinase z promotes actin cytoskeleton remodeling and mechanical forces at the B cell immune synapse [PDF]

, 2020
International audienceDiacylglycerol kinases (DGKs) limit antigen receptor signaling in immune cells by consuming the second messenger diacylglycerol (DAG) to generate phosphatidic acid (PA).
Roman-Garcia, Sara, Husson, Julien, Gardeta, Sofia, R, Pineau, Judith, Merino-Cortés, Sara,, Merino-Cortés, Sara, V, Alarcon, Balbino, Carrasco, Yolanda,, Merida, Isabel, Carrasco, Yolanda, R, Martínez-Riaño, Ana, Dumenil, Ana-Maria Lennon, Pierobon, Paolo, Liebana, Rosa, Gardeta, Sofia,, Merino-Cortés, Sara V., Carrasco, Yolanda R., Lennon Dumenil, Ana-María, Gardeta, Sofía   +18 more
core   +1 more source

Biomass DNA: An Emerging Building Block for Advanced Materials

Advanced Materials, EarlyView.
Biomass DNA is rapidly emerging from its traditional role as a genetic blueprint to serve as a versatile abundant, highly programmable polymeric building block. This review highlights the transformation of macroscopic bulk biomass DNA into next generation of functional materials, spanning from dynamic hydrogels, sustainable bioplastics, and high ...
Yuwei Hu, Itamar Willner, Li Niu
wiley   +1 more source

LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics

Journal for ImmunoTherapy of Cancer
Background A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape.
Chao Chen, Jingwei Zheng, Xian Shen, Qiaoyi Xu, Xiangyang Xue, Teming Zhang, Yingying Sun, Liyun Chang, Yizhen Xiang, Qiongying Zhang, Haoliang Li, Wangkai Xie, Chenchen Mao, Mingdong Lu, Zhenzhai Cai, Zheng Han   +15 more
doaj   +1 more source