Results 111 to 120 of about 1,158,960 (278)

Immune synapses make a choice

The Journal of Cell Biology, 2004
The immunological synapse between T cells and the antigen-presenting dendritic cells acts as a locus for T cell activation. Now, Roberto Maldonado, Laurie Glimcher (Harvard School of Public Health, Boston, MA), and colleagues find that this synapse also helps the T cells decide between two ...
openaire   +2 more sources

T2T Genome Assembly and Multi‐Omics Data Reveal Terrestrial Adaptation and Mucus Biosynthesis in Tropical Leatherleaf Slug (Laevicaulis alte)

Advanced Science, EarlyView.
A gap‐free genome assembly and multi‐omics comparison of the terrestrial slug Laevichaulis alte with an aquatic relative reveal that expansion of the VEGF family orchestrates mucus production, lipid metabolism, and immune defense—highlighting key molecular innovations for conquering life on land.
Gang Wang, Shaofang He, Zhongkai Wang, Aobo Pang, Xiaoli Sun, Rongchen Liu, Fang Wang, Sisi Chen, Zhijuan Bian, Dongcheng Wei, Liuhan Wu, Siyao Zhao, Qiuting Ji, Yiqi Sun, Niying Sun, Yushinta Fujaya, Boping Tang, Kianann Tan, Daizhen Zhang, Lianfu Chen   +19 more
wiley   +1 more source

SPADE: A Deep Learning Framework for Spatial Mapping and Quantitative Cell–Cell Interaction Inference

Advanced Science, EarlyView.
SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley   +1 more source

Condition‐Associated Pattern Extraction and Recovery From Multi‐Condition Single‐Cell RNA‐seq Data With CAPER

Advanced Science, EarlyView.
Decoupling biological signals from unwanted variation in multi‑condition single‑cell RNA sequencing data remains challenging. CAPER disentangles condition‑associated biological effects from sample heterogeneity through matrix factorization, producing interpretable latent factors and a batch‑corrected expression matrix.
Ye Li, Jin Ning, An Wang, Minxi Shi, Yuanze Chen, Guoliang Liu, Shiquan Sun   +6 more
wiley   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

DOCK8 in immune cells: roles and mechanisms

Frontiers in Immunology
DOCK8 (dedicator of cytokinesis 8) is a prominent member of the DOCK−C subfamily and functions as an atypical guanine nucleotide exchange factor (GEF).
Zixuan Liao, Sicheng Luo, Weijie Shen, Huiru Lv, Zekai Xu, Li Xu   +5 more
doaj   +1 more source

The dendritic cell side of the immunological synapse

Biomolecular Concepts, 2016
Immune responses are initiated by the interactions between antigen-presenting cells (APCs), such as dendritic cells (DCs), with responder cells, such as T cells, via a tight cellular contact interface called the immunological synapse.
Verboogen Danielle R.J., Dingjan Ilse, Revelo Natalia H., Visser Linda J., ter Beest Martin, van den Bogaart Geert   +5 more
doaj   +1 more source

Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation [PDF]

, 2007
T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS).
Joaquin Madrenas, Maria E. Marquez, Mark G. Kirchhof, Isaac Blaca, Peter J. Darlington, Santosh Vardhana, Luan A. Chau, Roy Taylor, Caitlin D. Lemke, Kamilia Rizkalla, Michael L. Dustin   +10 more
core  

Multi‐Component Functionalized Bifidobacterium Longum Hydrogel for Multi‐Target Integrated Therapy of Colitis‐Associated Anxiety and Depression

Advanced Science, EarlyView.
A pH/MMP dual‐responsive Bifidobacterium longum (BL) hydrogel (INPs@BL@Gel) functionalized with baicalin, tyrosine, and inulin is constructed. It enables gastric protection, inflammation‐targeted release, and prolonged intestinal colonization. By remodeling gut microbiota, elevating beneficial neuroactive metabolites (homovanillic acid, short‐chain ...
Shuo Zhang, Yujie Zhang, Jiansheng He, Shunlian Li, Qingyan Ma, Qiao Li, Yudan Zhang, Yiyang Wang, Shaobo Ma, Songyan Jin, Chune Li, Xueyong Xie, Hang Zhang, Junze Deng, Xueqin Song, Daocheng Wu, Xiancang Ma, Feng Zhu   +17 more
wiley   +1 more source

Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain

Nature Communications
Activation of spinal microglia following peripheral nerve injury is a central component of neuropathic pain pathology. While the contributions of microglia-mediated immune and neurotrophic signalling have been well-characterized, the phagocytic and ...
Noosha Yousefpour, Shannon N. Tansley, Samantha Locke, Behrang Sharif, Marc Parisien, Farin B. Bourojeni, Haley Deamond, Vidhu Mathur, Nia Rahman-Khan Arana, Jean Sebastien Austin, Valerie Bourassa, Chengyang Wang, Valérie C. Cabana, Calvin Wong, Kevin C. Lister, Rose Rodrigues, Manon St-Louis, Marie-Eve Paquet, Michael C. Carroll, Yaisa Andrews-Zwilling, Philippe Seguela, Artur Kania, Ted Yednock, Jeffrey S. Mogil, Yves De Koninck, Luda Diatchenko, Arkady Khoutorsky, Alfredo Ribeiro-da-Silva   +27 more
doaj   +1 more source