Results 131 to 140 of about 1,284,834 (277)
Advanced Science, EarlyView.Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi +7 more
wiley +1 more source
Advanced Science, EarlyView.ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao +6 more
wiley +1 more source
, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Felipe Del Valle Batalla (6373913) +4 more
core +1 more source
Advanced Science, EarlyView.Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin +9 more
wiley +1 more source
, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Felipe Del Valle Batalla (6373913) +4 more
core +1 more source
Advanced Science, EarlyView.Peptide‐inspired associative polymers with arginine‐like guanidinium stickers and lysine‐like ammonium spacers undergo chain collapse and liquid‐liquid phase separation induced by reversible sticker associations. Sticker valence and tunable association strength jointly control the phase behavior, chain conformation, and interfacial cohesion of these ...
Seung‐Hwan Oh +7 more
wiley +1 more source
, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Felipe Del Valle Batalla (6373913) +4 more
core +1 more source
Advanced Science, EarlyView.In microglia, STAT3 upregulates TAB2, which promotes NF‐κB activation through its NZF domain‐mediated recognition of K63‐linked ubiquitin chains, leading to inflammatory cytokine release and subsequent neuronal injury. Lumacaftor suppresses TAB2 expression and directly binds the TAB2‐NZF domain to interrupt K63 ubiquitin recognition, thereby blocking ...
Yanhao Zhao +12 more
wiley +1 more source
, 2019 Engagement of the B cell receptor (BCR) with surface-tethered antigens leads to the formation of an immune synapse (IS), where cell signaling and antigen uptake are tightly coordinated.
Felipe Del Valle Batalla (6373913) +4 more
core +1 more source
Advanced Science, EarlyView.Photobiomodulated microglia release engineered extracellular vesicles that deliver UFL1 to the injured spinal cord. UFL1 competitively binds p53 with MDM2, inhibiting p53 ubiquitination and stabilizing p53 signaling. This dual mechanism simultaneously promotes anti‐inflammatory microglial polarization and directs neural stem cell differentiation toward
Yunxiao Fang +12 more
wiley +1 more source