Results 141 to 150 of about 73,161 (247)

Phollow the phosphoinositol: Actin dynamics at the B cell immune synapse. [PDF]

J Cell Biol, 2022
Wang MS, Huse M.
europepmc   +1 more source

Atypical Clinical Course of Griscelli Syndrome Type 2 With Primarily Neurologic Presentation and Adult‐Onset in a 46‐Year‐Old Male

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi, Michael Kutsche, Helena Lichtenfeld, Fanny Kortüm, Angela Abicht, Laura Herrmann, Theresia Herget   +6 more
wiley   +1 more source

RASA2 deletion rescues immune synapse dysfunction, enhancing CAR T cell efficacy against DMGs. [PDF]

J Immunother Cancer
Ibanez-Vega J, Teis R, Ocasio JK, Chockley P, Ansari A, Allo Anido A, Mehta S, Meehl M, Prinzing B, Ward M, Odde D, Baker S, Krenciute G.   +12 more
europepmc   +1 more source

Enhancing CAR- and TCR-mediated targeting of cancer via an immune synapse-stabilizing receptor. [PDF]

Nat Commun
Tsai CT, Ibanez-Vega J, Yin P, Teis R, Watanabe N, Honda T, Valkov M, Chockley PJ, Madrigal LAJ, Krenciute G, Mamonkin M.   +10 more
europepmc   +1 more source

Immune synapse formation promotes lipid peroxidation and MHC-I upregulation in licensed dendritic cells for efficient priming of CD8⁺ T cells. [PDF]

Nat Commun, 2023
Calzada-Fraile D, Iborra S, Ramírez-Huesca M, Jorge I, Dotta E, Hernández-García E, Martín-Cófreces N, Nistal-Villán E, Veiga E, Vázquez J, Pasqual G, Sánchez-Madrid F.   +11 more
europepmc   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Antigen mobility regulates the dynamics and precision of antigen capture in the B cell immune synapse. [PDF]

Proc Natl Acad Sci U S A
McArthur HCW, Bajur AT, Iliopoulou M, Spillane KM.   +3 more
europepmc   +2 more sources

Click Chemistry Mediated Immune Synapse Augmentation in Natural Killer Cell-Cancer Membrane Engagement and Facilitated Anticancer Efficacies of Natural Killer Cell Therapy. [PDF]

Biomater Res
Noh KM, Jangid AK, Kim E, Kim K.
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

CLASP1/2 regulate immune synapse maturation in natural killer cells. [PDF]

J Leukoc Biol
Pariani AP, Huhn V, Rivabella Maknis T, Alonso V, Almada E, Zecchinati F, Vena R, Ojeda M, Favre C, Goldenring JR, Kaverina I, Larocca MC.   +11 more
europepmc   +1 more source