Results 81 to 90 of about 1,284,834 (277)
Frontiers in Immunology, 2013 Imaging technology has undergone rapid growth with the development of super resolution microscopy, which enables resolution below the diffraction barrier of light (~200 nm).
Emily M. Mace +3 more
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Advanced Functional Materials, EarlyView.Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou +6 more
wiley +1 more source
Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration
Advanced Healthcare Materials, EarlyView.This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu +4 more
wiley +1 more source
Analysis of the kinomic and immune cancer synapse in GBM
, 2021 A deeper understanding of the signalling networks operating in vivo is needed to develop more physiologically relevant ex-vivo models and support the discovery of new therapeutics in human cancer. An example is human brain cancer where new therapeutics using essentially cancer cell models has failed to deliver therapeutic that work well in vivo.
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Studying the Immune Synapse in HIV-1 Infection [PDF]
, 2017 T cells are the main cellular targets of the human immunodeficiency virus 1 (HIV-1). HIV-1 infection induces pleiotropic effects on the infected T cell that modify the T cell capacity to respond to antigen and facilitates virus replication. HIV-1 infection subverts the formation and function of the immunological synapse altering both actin cytoskeleton
del Río-Iñiguez, Iratxe +2 more
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Calcium influx through CRAC channels controls actin organization and dynamics at the immune synapse
eLife, 2016 T cell receptor (TCR) engagement opens Ca2+ release-activated Ca2+ (CRAC) channels and triggers formation of an immune synapse between T cells and antigen-presenting cells.
Catherine A Hartzell +3 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar +2 more
wiley +1 more source
Dendritic Cells and HIV-1 Trans-Infection
Viruses, 2010 Dendritic cells initiate and sustain immune responses by migrating to sites of pathogenic insult, transporting antigens to lymphoid tissues and signaling immune specific activation of T cells through the formation of the immunological synapse.
David McDonald
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Advanced Healthcare Materials, EarlyView.Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez +12 more
wiley +1 more source
Mitochondria move to immune synapse [PDF]
The Journal of Cell Biology, 2007 ![][1] Mitochondria (white, bottom) move toward the immune synapse (right) to help prevent calcium from closing calcium channels. HOTH/NAS Arendezvous among mitochondria and the juncture between immune cells is needed to jumpstart T cells, according to results from Ariel Quintana,
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