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Comparative anatomy of phagocytic and immunological synapses [PDF]
Frontiers in Immunology, 2016 The generation of phagocytic cups and immunological synapses are crucial events of the innate and adaptive immune responses, respectively. They are triggered by distinct immune receptors and performed by different cell types.
Florence eNiedergang +2 more
doaj +4 more sources
Molecular Immunology, 2002 The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they
Terrazzini, Nadia; id_orcid +2 more
core +3 more sources
Formation and function of the immunological synapse.
Current Opinion in Immunology, 2002 Less than five years ago it was reported that cell surface molecules at the contact site between CD4 T cells and antigen-presenting cells redistribute into distinct patterns, forming an organized interface termed the immunological synapse. More recently,
Van Der Merwe, Philip +1 more
core +4 more sources
NgR1 is an NK cell inhibitory receptor that destabilizes the immunological synapse
Nature Immunology, 2023 The formation of an immunological synapse (IS) is essential for natural killer (NK) cells to eliminate target cells. Despite an advanced understanding of the characteristics of the IS and its formation processes, the mechanisms that regulate its ...
Se-Chan Oh +11 more
semanticscholar +1 more source
Despite disorganized synapse structure, Th2 cells maintain directional delivery of CD40L to antigen-presenting B cells. [PDF]
PLoS ONE, 2017 Upon recognition of peptide displayed on MHC molecules, Th1 and Th2 cells form distinct immunological synapse structures. Th1 cells have a bull's eye synapse structure with TCR/ MHC-peptide interactions occurring central to a ring of adhesion molecules ...
Jennifer L Gardell, David C Parker
doaj +1 more source
Immunity, 2022 Germinal centers (GCs), transient structures within B cell follicles and central to affinity maturation, require the coordinated behavior of T and B cells. IL-21, a pleiotropic T cell-derived cytokine, is key to GC biology through incompletely understood
Isaak Quast +12 more
semanticscholar +1 more source
bioRxiv, 2022 Ligation of the T cell receptor (TCR) to peptide-MHC complexes initiates signaling leading to T cell activation. Regulation of T cell responses also requires mechanisms to stop this signaling and to downregulate surface expression of the receptor.
Audun Kvalvaag +6 more
semanticscholar +1 more source
Cytotoxic immunological synapses [PDF]
Immunological Reviews, 2010 Summary: One of the most fundamental activities of the adaptive immune system is to kill infected cells and tumor cells. Two distinct pathways mediate this process, both of which are facilitated by a cytotoxic immunological synapse. While traditionally thought of as innate immune cells, natural killer (NK) cells are now appreciated to have the ...
Dustin, M, Long, E
openaire +3 more sources
Frontiers in Cell and Developmental Biology, 2021 Natural killer (NK) cells are innate lymphoid cells, which play key roles in elimination of virally infected and malignant cells. The balance between activating and inhibitory signals derived from NK surface receptors govern the NK cell immune response ...
Aviad Ben-Shmuel +3 more
doaj +1 more source
Frontiers in Immunology, 2022 Hemichannels (HCs)/gap junctions (GJs) and immunoglobulin (Ig)-like domain-containing proteins (IGLDCPs) are involved in the innate–adaptive immune response independently.
Jiang-Hui Meng +8 more
doaj +1 more source