Results 41 to 50 of about 226,715 (279)
RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. [PDF]
PLoS ONE, 2010 RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells,
Hee-Don Chae +4 more
doaj +1 more source
Imaging the Human Immunological Synapse [PDF]
Journal of Visualized Experiments, 2019 The purpose of the method is to generate an immunological synapse (IS), an example of cell-to-cell conjugation formed by an antigen-presenting cell (APC) and an effector helper T lymphocyte (Th) cell, and to record the images corresponding to the first stages of the IS formation and the subsequent trafficking events (occurring both in the APC and in ...
Bello-Gamboa, Ana +8 more
openaire +4 more sources
T lymphocyte myosin IIA is required for maturation of the immunological synapse
Frontiers in Immunology, 2012 The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial.
Sudha eKumari +6 more
doaj +1 more source
Chemokines and the immunological synapse
Immunology, 2002 The critical event which initiates an adaptive immune response is the interaction of T cells through the T-cell antigen receptor (TCR) with major histocompatibility complex (MHC)–peptide (MHCp) complexes on the surface of antigen-presenting cells (APCs).
openaire +3 more sources
Mechanical Communication at the Immunological Synapse [PDF]
Trends in Cell Biology, 2017 T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force.
Roshni, Basu, Morgan, Huse
openaire +2 more sources
Orchestration of Immunological Synapse Assembly by Vesicular Trafficking
Frontiers in Cell and Developmental Biology, 2019 Ligation of the T-cell antigen receptor (TCR) by cognate peptide bound to the Major Histocompatibility Complex on the surface of an antigen-presenting cell (APC) leads to the spatial reorganization of the TCR and accessory receptors to form a specialized
Anna Onnis, Cosima T. Baldari
doaj +1 more source
The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Nature Communications, 2022 HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva +5 more
doaj +1 more source
Immunological synapse DC-Tcells
, 2017 Immunological synapse DC ...
Leithner, Alexander F ; https://orcid.org/
core +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill +6 more
wiley +1 more source