Results 41 to 50 of about 241,841 (240)

Altered actin centripetal retrograde flow in physically restricted immunological synapses.

PLoS ONE, 2010
Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu, Hung-jen Wu, Yoshihisa Kaizuka, Ronald D Vale, Jay T Groves   +4 more
doaj   +1 more source

Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation [PDF]

, 2007
T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS).
Joaquin Madrenas, Maria E. Marquez, Mark G. Kirchhof, Isaac Blaca, Peter J. Darlington, Santosh Vardhana, Luan A. Chau, Roy Taylor, Caitlin D. Lemke, Kamilia Rizkalla, Michael L. Dustin   +10 more
core  

Immunological Synapse

, 2015
International audienceImmunological synapses are dynamically organised cell–cell interfaces formed between cells of the immune system. Different types of immunological synapses lead to distinct functional outcomes.
Jérôme Bouchet, Bouchet, Jérôme, Agüera-Gonzalez, Sonia, Andrés Alcover, Sonia Agüera‐Gonzalez, Alcover, Andrés   +5 more
core   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

Serostatus‐Specific Prognostic Profiles and Phenotype‐Dependent Therapeutic Windows in Autoimmune Encephalitis: A Multicenter Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background While autoimmune encephalitis (AE) outcomes vary, serostatus‐specific prognostic determinants and institutional clustering effects remain poorly characterized. We aimed to delineate the distinct prognostic architecture of AE, identifying serostatus‐specific risk factors and potential therapeutic windows.
Xiaohong Tang, Jingxian Wang, Kaixin Zhu, Zhen Zhang, Liao Wu, Wei Wang, Chang Li, Qingyun Li, Hao Li, Jinghua Chen, Zhangxu Lian, Bin Liu, Tengfei Liu, Chunmei Wen, Nuan Wang, Sen Qun, Lishun Xiao, Qingwei Lai   +17 more
wiley   +1 more source

NKp46 clusters at the immune synapse and regulates NK cell polarization

Frontiers in Immunology, 2015
Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad, Uzi eHadad, Timothy J Thauland, Olivia M Martinez, Manish J Butte, Angel ePorgador, Sheri M Krams   +6 more
doaj   +1 more source

Signaling and the immunological synapse

, 2010
This chapter deals with T cell activation and immunological synapses. It begins with a brief summary of T cell biology to put a discussion of immune synapses into a broader context because the study of immunological synapses addresses issues pertaining ...
Andrey S. Shaw, Emanuele Giurisato, Giurisato, Emanuele, Shaw, Andrey S.   +3 more
core   +1 more source

A role for TASK2 channels in the human immunological synapse

, 2020
The immunological synapse is a transient junction that occurs when the plasma membrane of a T cell comes in close contact with an APC after recognizing a peptide from the antigen-MHC.
Sauer, Markus, Rolfes, Leoni, Dieterich, Daniela C., Gola, Lukas, Smalla, Dr. Karl-Heinz, Meuth, Sven G., Fernandez-Orth, Juncal, Sukhorukov, Vladimir L., Cerina, Manuela, Kähne, Thilo, Sisario, Dmitri, Andronic, Joseph, Budde, Thomas, Kovac, Stjepana, Bittner, Stefan, Ruck, Tobias   +15 more
core   +1 more source

Macrophage–Fibroblast Crosstalk Governs Tumor Mechanics, as Revealed by Spatiotemporal Force Mapping in 3D Spheroids

Advanced Healthcare Materials, EarlyView.
This study shows crosstalk among tumor cells, fibroblasts, and macrophages alters the physical forces inside 3D tumor spheroids. Incorporating deformable microparticles in 3D tumor spheroids, the researchers mapped mechanical stresses spatially and with respect to tumor growth (temporally).
Kunal P. Pednekar, Daan Vorselen, Jai Prakash   +2 more
wiley   +1 more source

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

eLife, 2015
Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet,
Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin   +10 more
doaj   +1 more source