Results 51 to 60 of about 565,531 (300)

Single-Molecule, Super-Resolution, and Functional Analysis of G Protein-Coupled Receptor Behavior Within the T Cell Immunological Synapse

Frontiers in Cell and Developmental Biology, 2021
A central process in immunity is the activation of T cells through interaction of T cell receptors (TCRs) with agonistic peptide-major histocompatibility complexes (pMHC) on the surface of antigen presenting cells (APCs).
J. Felce, L. Parolini, E. Sezgin, P. Céspedes, K. Korobchevskaya, Mathew Jones, Yanchun Peng, T. Dong, M. Fritzsche, D. Aarts, J. Frater, Michael Loran Dustin   +11 more
semanticscholar   +1 more source

Differential segregation in a cell-cell contact interface: the dynamics of the immunological synapse [PDF]

, 2002
Receptor-ligand couples in the cell-cell contact interface between a T cell and an antigen-presenting cell form distinct geometric patterns and undergo spatial rearrangement within the contact interface.
Nigel John Burroughs, Burroughs, Nigel John, Wülfing, Christoph, Christoph Wülfing   +3 more
core   +1 more source

T-Cell activation: a queuing theory analysis at low agonist density [PDF]

, 2006
We analyze a simple linear triggering model of the T-cell receptor (TCR) within the framework of queuing theory, in which TCRs enter the queue upon full activation and exit by downregulation.
Wedagedera, J.R., Burroughs, N.J., Burroughs, Nigel John, Wedagedera, J. R.   +3 more
core   +1 more source

A dynamic CD2 rich compartment at the outer edge of the immunological synapse boosts and integrates signals

Nature Immunology, 2020
The CD2–CD58 recognition system promotes adhesion and signaling and counters exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature immunological synapse, with cellular or artificial APC, in a pattern we refer to as a ...
P. Demetriou, E. Abu-Shah, Salvatore Valvo, Sarah McCuaig, V. Mayya, Audun Kvalvaag, T. Starkey, K. Korobchevskaya, Lennard Y. W. Lee, M. Friedrich, E. Mann, Mikhail A. Kutuzov, M. Morotti, N. Wietek, Heather Rada, Shamsideen Yusuf, Jehan Afrose, A. Siokis, M. Meyer-Hermann, A. Ahmed, D. Depoil, Michael Loran Dustin   +21 more
semanticscholar   +1 more source

Centriole polarisation to the immunological synapse directs secretion from cytolytic cells of both the innate and adaptive immune systems

BMC Biology, 2011
Background Cytolytic cells of the immune system destroy pathogen-infected cells by polarised exocytosis of secretory lysosomes containing the pore-forming protein perforin. Precise delivery of this lethal hit is essential to ensuring that only the target
Arico Maurizo, Pende Daniela, Cerundolo Vincenzo, Salio Mariolina, Stinchcombe Jane C, Griffiths Gillian M   +5 more
doaj   +1 more source

Identification of distinct cytotoxic granules as the origin of supramolecular attack particles in T lymphocytes

Nature Communications, 2022
Cytotoxic T cells have specialised granules that are important for mediating their killing function. Here the authors characterise two types of cytotoxic granules and indicate different functions and temporal release of mediators at the immunological ...
Hsin-Fang Chang, Claudia Schirra, Momchil Ninov, Ulrike Hahn, Keerthana Ravichandran, Elmar Krause, Ute Becherer, Štefan Bálint, Maria Harkiolaki, Henning Urlaub, Salvatore Valitutti, Cosima T. Baldari, Michael L. Dustin, Reinhard Jahn, Jens Rettig   +14 more
doaj   +1 more source

Action and traction: cytoskeletal control of receptor triggering at the immunological synapse

Frontiers in Immunology, 2016
It is well known that F-actin dynamics drive micron-scale cell shape changes required for migration and immunological synapse formation. In addition, recent evidence points to a more intimate role for the actin cytoskeleton in promoting T cell activation.
Janis K. Burkhardt, William A Comrie
doaj   +1 more source

Lipid switches in the immunological synapse. [PDF]

J Biol Chem
Adaptive immune responses comprise the activation of T cells by peptide antigens that are presented by proteins of the Major Histocompatibility Complex (MHC) on the surface of an antigen-presenting cell. As a consequence of the T cell receptor interacting productively with a certain peptide-MHC complex, a specialized cell-cell junction known as the ...
Griffiths G, Brügger B, Freund C.
europepmc   +4 more sources

In vitro Assessment of Immunological Synapse Formation by Flow Cytometry

Bio-Protocol, 2016
In adaptive immune system, formation of immunological synapse between T cells and antigen presenting cells (dendritic cells, B cells, and macrophages) or target cells (tumor cells and viral-infected cells) is critical for the execution of T cell immune ...
Bo-Ra Na, Chang-Duk Jun
doaj   +1 more source

RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. [PDF]

PLoS ONE, 2010
RhoH is an hematopoietic-specific, GTPase-deficient Rho GTPase that plays a role in T development. We investigated the mechanisms of RhoH function in TCR signaling. We found that the association between Lck and CD3ζ was impaired in RhoH-deficient T cells,
Hee-Don Chae, Jamie E Siefring, David A Hildeman, Yi Gu, David A Williams   +4 more
doaj   +1 more source