Results 51 to 60 of about 52,207 (332)

T-cell modulation for the treatment of chronic plaque psoriasis with efalizumab (Raptiva (TM)): Mechanisms of action [PDF]

, 2004
Psoriasis is a chronic, incurable, auto-immune disorder with cutaneous manifestations. New evidence on the central role of the immune system in the pathogenesis of psoriasis increasingly provides insight into pathogenic steps that can be modulated to ...
Caro, I., Dedrick, R., Dummer, W., Joshi, A., Jullien, D., Langley, RGB, Natta, P., Prinz, Jörg Christoph   +7 more
core   +1 more source

HIV-1 Activates T Cell Signaling Independently of Antigen to Drive Viral Spread [PDF]

, 2016
open access articleHIV-1 spreads between CD4 T cells most efficiently through virus-induced cell-cell contacts. To test whether this process potentiates viral spread by activating signaling pathways, we developed an approach to analyze the ...
Jolly, Clare, Len, Alice C.L., Shivkumar, Maitreyi, Starling, Shimona   +3 more
core   +2 more sources

Altered actin centripetal retrograde flow in physically restricted immunological synapses.

PLoS ONE, 2010
Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu, Hung-jen Wu, Yoshihisa Kaizuka, Ronald D Vale, Jay T Groves   +4 more
doaj   +1 more source

Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC [PDF]

, 2012
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trojan, AD Hamblin, AG Ramsay, AG Ramsay, AM Krackhardt, AP Kater, AP Kater, BL McClune, C Haller, C Mayr, C Nabhan, CA Rodrigues, D Bagnara, D Dilloo, D Wolf, D Xing, DA Mavroudis, DL Porter, Dongxia Xing, Elizabeth J. Shpall, Hiroshi Shiku, Hong Yang, I Ben-Bassat, I Hus, IF Khouri, J Chen, Jeffrey J. Molldrem, JG Gribben, JG Gribben, JM Rudolph, John G. Gribben, JS Miller, K Kato, M Hoogendorn, M Ritgen, MA King, Matthew M. Halpert, MF Bachmann, Michael J. Keating, N Shah, Nina Shah, R Le Dieu, R Mous, Ruth Lapushin, S Miscia, S Parmar, S Samarasinghe, Simon N. Robinson, Simrit Parmar, SL Martins, SM Schmidt, Sufang Li, T Nishida, WG Wierda, William G. Wierda, William K. Decker, WK Decker   +56 more
core   +2 more sources

Adhesion of membranes via receptor-ligand complexes: Domain formation, binding cooperativity, and active processes [PDF]

, 2009
Cell membranes interact via anchored receptor and ligand molecules. Central questions on cell adhesion concern the binding affinity of these membrane-anchored molecules, the mechanisms leading to the receptor-ligand domains observed during adhesion, and ...
Albersdörfer, Alon, Arnold, Asfaw, Auth, Baksh, Bartosz Różycki, Bayas, Bell, Bell, Bershadsky, Bruinsma, Bunnell, Burroughs, Campi, Chen, Chen, Chesla, Choudhuri, Coombs, Davis, Davis, De, Delanoe-Ayari, DeMond, Discher, Dustin, Dustin, Dustin, Dustin, Dustin, Dustin, El Alaoui Faris, Figge, Fournier, Geiger, Girard, Goetz, Gov, Gov, Gov, Grakoui, Gruhn, Heinrich Krobath, Helfrich, Hu, Huang, Ichimura, Irvine, Jeppesen, Kim, Kloboucek, Komura, Krobath, Krogsgaard, Leckband, Lee, Lin, Lin, Lipowsky, Lipowsky, Lorz, Maier, Manneville, Martin, McDonnell, Mesfin Asfaw, Monks, Moore, Moreira, Mossman, Möller, Orsello, Prost, Purbhoo, Purrucker, Qi, Ramaswamy, Raychaudhuri, Reinhard Lipowsky, Reister-Gottfried, Rich, Różycki, Różycki, Różycki, Różycki, Sabra, Sako, Schuck, Schwarz, Schütz, Seifert, Selhuber-Unkel, Shenoy, Smith, Smith, Smith, Takagi, Thomas R. Weikl, Tolentino, Tordeux, Tsourkas, Tsourkas, Varma, Weikl, Weikl, Weikl, Weikl, Weikl, Williams, Winter, Wu, Yokosuka, Yokosuka, Yokosuka, Zhang, Zhu   +116 more
core   +2 more sources

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

eLife, 2015
Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet,
Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin   +10 more
doaj   +1 more source

First-passage time to clear the way for receptor-ligand binding in a crowded environment [PDF]

, 2016
Certain biological reactions, such as receptor-ligand binding at cell-cell interfaces and macromolecules binding to biopolymers, require many smaller molecules crowding a reaction site to be cleared. Examples include the T cell interface, a key player in
Allard, Jun, Newby, Jay
core   +3 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

Frontiers in Immunology, 2019
The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation.
Julia M. Laufer, Julia M. Laufer, Ilona Kindinger, Marc Artinger, Marc Artinger, Andreas Pauli, Daniel F. Legler, Daniel F. Legler   +7 more
doaj   +1 more source