Results 51 to 60 of about 241,841 (240)

T cell receptor signaling precedes immunological synapse formation.

, 2002
The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in
Andrey S. Shaw, Amy D. Holdorf, Paul M. Allen, Kyeong-Hee Lee, Michael L. Dustin, Andrew C. Chan   +5 more
core   +1 more source

Advances in Bio‐Integrated Edge Computing Systems for Smart and Connected Health

Advanced Materials, EarlyView.
This review explores advances in bio‐integrated edge computing for healthcare, focusing on co‐designing computing, sensing, and energy strategies to overcome integration and power challenges for optimized, decentralized operation. ABSTRACT Recent advances in bio‐integrated healthcare technologies have enabled continuous, high‐resolution monitoring and ...
Gyuwon Kim, Seungwon Yoo, Tae Woog Kang, Yunuo Huang, Woon‐Hong Yeo   +4 more
wiley   +1 more source

LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics

Journal for ImmunoTherapy of Cancer
Background A substantial amount of research has been dedicated to the mechanisms by which tumor cells evade immune system recognition and manipulate the immune microenvironment to facilitate immune escape.
Chao Chen, Jingwei Zheng, Xian Shen, Qiaoyi Xu, Xiangyang Xue, Teming Zhang, Yingying Sun, Liyun Chang, Yizhen Xiang, Qiongying Zhang, Haoliang Li, Wangkai Xie, Chenchen Mao, Mingdong Lu, Zhenzhai Cai, Zheng Han   +15 more
doaj   +1 more source

CCR7 Is Recruited to the Immunological Synapse, Acts as Co-stimulatory Molecule and Drives LFA-1 Clustering for Efficient T Cell Adhesion Through ZAP70

Frontiers in Immunology, 2019
The chemokine receptor CCR7 guides T cells and dendritic cells to and within lymph nodes to launch the onset of adaptive immunity. Here, we demonstrate that CCR7 in addition acts as a potent co-stimulatory molecule in T cell activation.
Julia M. Laufer, Julia M. Laufer, Ilona Kindinger, Marc Artinger, Marc Artinger, Andreas Pauli, Daniel F. Legler, Daniel F. Legler   +7 more
doaj   +1 more source

Understanding the structure and function of the immunological synapse.

, 2010
The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial.
A. K. Chakraborty, M. L. Dustin, A. S. Shaw   +2 more
core   +1 more source

Masters of manipulation: Viral modulation of the immunological synapse [PDF]

, 2018
In order to thrive, viruses have evolved to manipulate host cell machinery for their own benefit. One major obstacle faced by pathogens is the immunological synapse.
Vincent Piguet, Bayliss, Rebecca J., Piguet, Vincent, Rebecca J. Bayliss   +3 more
core   +1 more source

Bacteria‐Trained, MnO2‐Armored Dendritic Cells for Immunotherapy

Advanced Materials, EarlyView.
MnO2‐armored, bacteria‐trained dendritic cells undergo tumor‐responsive mechanical and immunological transformation. The nanocoating masks immune ligands and maintains a mechanically stiff, quiescent state during circulation, while the tumor microenvironment removes the armor and restores cellular deformability and immune accessibility.
Zhao Guo, Min Ge, Zesong Ruan, Tingwang Shi, Mahyar Mahmoudi, Soohwan An, Na Kong, Yunfeng Chen, Han Lin, Wei Tao   +9 more
wiley   +1 more source

Microtubule dynamics and signal transduction at the immunological synapse: new partners and new connections.

, 2012
International audienceAntigen recognition induces T cells to polarize towards antigen presenting cells (APC) generating an organized cell interface named the immunological synapse. T-cell microtubules (MTs) reorient the MT-organizing centre (MTOC) to the
Lasserre, Rémi, Alcover, Andrès
core   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

From tango to quadrilla: current views of the immunological synapse

, 2007
All T cell functions require establishing contacts with other cells. In the last ten years, the immunological synapse, the contact-site between T cells and their partners, has been the object of numerous investigations and recent advances in imaging ...
Cristina Mazzon, Mazzon, Cristina, C. Mazzon, Viola, Antonella, Antonella Viola, A. Viola   +5 more
core   +1 more source