Results 61 to 70 of about 29,641 (245)
Nature Communications, 2022 T cells communicate with antigen-presenting cells (APC) via the signaling crosstalk at the immunological synapse (IS). Here the authors use bead-supported lipid bilayers as synthetic APCs to find that trans-synaptic vesicles produced by T cells in the IS
Pablo F. Céspedes +25 more
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The immunological synapse as a pharmacological target
Pharmacological Research, 2018 The development of T cell mediated immunity relies on the assembly of a highly specialized interface between T cell and antigen presenting cell (APC), known as the immunological synapse (IS). IS assembly is triggered when the T cell receptor (TCR) binds to specific peptide antigen presented in association to the major histocompatibility complex (MHC ...
Finetti, Francesca, Baldari, Cosima T
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Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
Diversity in immunological synapse structure
Immunology, 2010 SummaryImmunological synapses (ISs) are formed at the T cell–antigen‐presenting cell (APC) interface during antigen recognition, and play a central role in T‐cell activation and in the delivery of effector functions. ISs were originally described as a peripheral ring of adhesion molecules surrounding a central accumulation of T‐cell receptor (TCR ...
Timothy J, Thauland, David C, Parker
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Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
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Effective Membrane Model of the Immunological Synapse [PDF]
Physical Review Letters, 2003 6 pages, 3 figures, submitted for ...
Raychaudhuri, Subhadip +2 more
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Advanced Science, EarlyView.In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu +13 more
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, 2015 Immunological synapses are dynamically organised cell–cell interfaces formed between cells of the immune system. Different types of immunological synapses lead to distinct functional outcomes. Thus, T and B lymphocytes form immunological synapses with each other and with dendritic cells or macrophages, conveying mutual activation cues.
Agüera-Gonzalez, Sonia +2 more
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Geometrically repatterned immunological synapses uncover formation mechanisms. [PDF]
PLoS Computational Biology, 2006 The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Marc Thilo Figge, Michael Meyer-Hermann
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Advanced Science, EarlyView.SPADE integrates spatial transcriptomics with single‐cell RNA sequencing by using cell–cell communications (CCC) as a guide for spatial mapping. It improves cell‐type localization, enhances sparse gene‐expression signals, and reveals CCC programs at single‐spot resolution.
Xinyi Li, Ning Zhang, Zijie Jin
wiley +1 more source