Results 61 to 70 of about 565,531 (300)
HIV-1 intersection with CD4 T cell vesicle exocytosis: intercellular communication goes viral
Frontiers in Immunology, 2014 In cells of the immune system the secretion of extracellular vesicles is modulated through cellular activation. In particular, T cell activation is achieved through cell-cell contacts with antigen presenting cells and the consequent formation of a ...
Helena eSoares, Helena eSoares
doaj +1 more source
Actin Engine in Immunological Synapse [PDF]
Immune Network, 2012 T cell activation and function require physical contact with antigen presenting cells at a specialized junctional structure known as the immunological synapse. Once formed, the immunological synapse leads to sustained T cell receptor-mediated signalling and stabilized adhesion.
Piragyte, Indre, Jun, Chang-Duk
openaire +2 more sources
Blood, 2020 A unique feature of Hodgkin lymphoma (HL) is the presence of CD4+ T cells that surround, protect and promote survival of tumor cells. The adhesion molecules involved in this so-called T cell rosetting are important components of the immunological synapse
J. Veldman +6 more
semanticscholar +1 more source
Mechanical Communication at the Immunological Synapse [PDF]
Trends in Cell Biology, 2017 T and B lymphocytes communicate by forming immunological synapses with antigen-presenting target cells. These highly dynamic contacts are characterized by continuous cytoskeletal remodeling events, which not only structure the interface but also exert a considerable amount of mechanical force.
Roshni, Basu, Morgan, Huse
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T lymphocyte myosin IIA is required for maturation of the immunological synapse
Frontiers in Immunology, 2012 The role of non-muscle myosin IIA (heavy chain encoded by the non-muscle myosin heavy chain 9 gene, Myh9) in immunological synapse formation is controversial.
Sudha eKumari +6 more
doaj +1 more source
The Immunological Synapse: a Dynamic Platform for Local Signaling [PDF]
, 2010 The immunological synapse (IS) as a concept has evolved from a static view of the junction between T cells and their antigen-presenting cell partners. The entire process of IS formation and extinction is now known to entail a dynamic reorganization of ...
Krummel, Matthew F. +3 more
core +3 more sources
Spatiotemporal Regulation of Signaling: Focus on T Cell Activation and the Immunological Synapse
International Journal of Molecular Sciences, 2020 In a signaling network, not only the functions of molecules are important but when (temporal) and where (spatial) those functions are exerted and orchestrated is what defines the signaling output.
Esther Garcia, S. Ismail
semanticscholar +1 more source
The role of the cytoskeleton at the immunological synapse [PDF]
Immunological Reviews, 2013 SummaryIt has been over 30 years since the reorganization of both the microtubule network and a ‘peculiar actin polarization’ was reported at the contact area of cytotoxic T lymphocytes interacting with target cells. Since that time, hundreds of studies have been published in an effort to elucidate the structure and function of the microtubule network ...
Ritter, Alex T +2 more
openaire +2 more sources
The immune synapses reveal aberrant functions of CD8 T cells during chronic HIV infection
Nature Communications, 2022 HIV infection over time is thought to result in premature aging and aberrant immune responses including the induction of immunological senescence. Here the authors show altered formation of immune synapses by naive CD8+ T cells and dysregulated synapse ...
Nadia Anikeeva +5 more
doaj +1 more source
Nature CommunicationsCancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions in tumour progression.
A. Varveri +15 more
semanticscholar +1 more source