Results 81 to 90 of about 226,715 (279)

Multi‐Omics Profiling of High‐Grade Serous Ovarian Cancer Reveals an Inflammation‐Related Lipid Metabolism Subtype Associated With Platinum Resistance

Advanced Science, EarlyView.
Through integrated proteomic and metabolomic profiling, Zhao et al. identified three molecular subtypes of high‐grade serous ovarian cancer. The high‐risk subtype exhibits activated arachidonic acid metabolism and cyclooxygenase‐2 overexpression. This metabolic axis promotes M2‐like macrophage infiltration, which contributes to platinum resistance ...
Yuxi Zhao, Junyi Li, Bo Zheng, Wanshan Liu, Yaru Wang, Shufeng Wang, Ying Cui, Huiqin Guo, Hongxia Wang, Ting Xiao, Kun Qian, Jing Zuo   +11 more
wiley   +1 more source

Effective Membrane Model of the Immunological Synapse [PDF]

Physical Review Letters, 2003
6 pages, 3 figures, submitted for ...
Raychaudhuri, Subhadip, Chakraborty, Arup K., Kardar, Mehran   +2 more
openaire   +3 more sources

The immunological synapse: a molecular machine controlling T cell activation.

, 1999
The specialized junction between a T lymphocyte and an antigen-presenting cell, the immunological synapse, consists of a central cluster of T cell receptors surrounded by a ring of adhesion molecules. Immunological synapse formation is now shown to be an
Shaw, AS, Andrey S. Shaw, Shannon K. Bromley, Davis, MM, Cenk Sumen, Sumen, C, Allen, PM, Mark M. Davis, Paul M. Allen, Dustin, Michael, Grakoui, A, Bromley, SK, Arash Grakoui, Dustin, ML, Michael L. Dustin   +14 more
core   +1 more source

Neuron‐Targeted Exosomal Delivery of siRNA Against RIPK3 Slows Neurodegenerative Progression in Alzheimer's Disease

Advanced Science, EarlyView.
Engineered exosomal siRNA delivery platform enables systemic, neuron‐targeted RNA transport across the blood–brain barrier. Surface functionalization with rabies virus glycoprotein‐derived peptide facilitates receptor‐mediated transcytosis, achieving efficient cytosolic delivery and robust gene silencing. Targeting RIPK3 suppresses necroptosis, reduces
Chi Zhang, Jiaqi Zhang, Yuzhi Wang, Yaodong Wang, Peng Lin, Yanling Wang, Zixuan Tang, Jintai Yu, Qin Zhou, Feiyun Cui   +9 more
wiley   +1 more source

Activation-induced polarized recycling targets T cell antigen receptors to the immunological synapse; involvement of SNARE complexes. [PDF]

, 2004
The mechanism by which T cell antigen receptors (TCR) accumulate at the immunological synapse has not been fully elucidated. Since TCRs are continuously internalized and recycled back to the cell surface, we investigated the role of polarized recycling ...
Roux, Pascal, Dujeancourt, Annick, Das, Vincent, Thoulouze, Maria-Isabel, Dautry-Varsat, Alice, Nal, Béatrice, Thoulouze, Marie-Isabelle, Alcover, Andrès, Galli, Thierry   +8 more
core   +1 more source

Alzheimer's Disease Beyond Amyloid: Lessons From Atherosclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Marcello Ciaccio, Luisa Agnello
wiley   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Understanding the structure and function of the immunological synapse.

, 2010
The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial.
Shaw, AS, A. K. Chakraborty, M. L. Dustin, Chakraborty, AK, A. S. Shaw, Dustin, ML, Dustin, Michael   +6 more
core   +1 more source

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses [PDF]

, 2011
Immune synapses formed by T and NK cells both show segregation of the integrin ICAM1 from other proteins such as CD2 (T cell) or KIR (NK cell).
Dustin, Michael L., van der Merwe P. Anton, Nigel J Burroughs, Michael L Dustin, Van Der Merwe, PA, P Anton van der Merwe, Nigel J. Burroughs, Miloserdov, Vladimir, Van der Merwe, P. Anton, Miloserdov, V, Davis, DM, Dustin, ML, Daniel M Davis, Daniel M. Davis, Davis Daniel M., Köhler, K, Michael L. Dustin, Miloserdov Vladimir, Karsten Köhler, Dustin, Michael, Burroughs Nigel J., Dustin Michael L., Burroughs, Nigel J., P. Anton van der Merwe, Davis, Daniel M., Burroughs, NJ, Köhler Karsten, Van Der Merwe, Philip, Köhler, Karsten, Burroughs, Nigel John, Vladimir Miloserdov   +30 more
core   +1 more source

Transposable Element–Driven PIEZO Mutation Enhances Locust Flight in Plateau Hypoxia

Advanced Science, EarlyView.
Why transposable elements (TEs) persisted or expanded in genomes remains a mystery. Using integrated analysis of TE macro‐ and microevolution in locusts, our results showed that thousands of TE insertions promoted widespread adaptive variation. Subfamilies of candidate adaptive TEs amplified and reshaped species‐level genomic architecture.
Xuanzhao Li, Ying Liu, Longsheng Xing, Xianliang Huang, Yingming Sun, Lei Yue, Yuze Zhang, Huilong Du, Bing Chen   +8 more
wiley   +1 more source