Results 81 to 90 of about 565,531 (300)
Chemokines and the immunological synapse
Immunology, 2002 The critical event which initiates an adaptive immune response is the interaction of T cells through the T-cell antigen receptor (TCR) with major histocompatibility complex (MHC)–peptide (MHCp) complexes on the surface of antigen-presenting cells (APCs).
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Advanced Science, EarlyView.A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang +19 more
wiley +1 more source
Immunological synapse: An emerging target for immune regulation
, 2023 Immunological synapse is termed as a steady interface between immune cells (mainly T-lymphocyte) i.e., derived from thymus along with adhesion molecules and antigen presenting cell (APC).
Nabaneeta Smaraki*1 , Harsh Rajeshbhai Jogi1 , Sonali Sonejita Nayak2, , Ashok Chaudhary2
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Advanced Science, EarlyView.ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo +14 more
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Immunological Synapse: Center of Attention Again
, 2008 The functional role of molecular clustering in the center of the immunological synapse is controversial. In this issue of Immunity, Čemerski et al.
Valitutti, Salvatore
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What Counts in the Immunological Synapse? [PDF]
Molecular Cell, 2014 Molecular interactions at the interface between helper T cells and antigen-presenting B cells govern the ability to produce specific antibodies, which is a central event in protective immunity generated by natural infection or man-made vaccines. In order for a T cell to deliver effective help to a B cell and guide affinity maturation, it needs to ...
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GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Selective transmission of R5 HIV-1 over X4 HIV-1 at the dendritic cell-T cell infectious synapse is determined by the T cell activation state. [PDF]
PLoS Pathogens, 2009 Dendritic cells (DCs) are essential antigen-presenting cells for the induction of T cell immunity against HIV. On the other hand, due to the susceptibility of DCs to HIV infection, virus replication is strongly enhanced in DC-T cell interaction via an ...
Takuya Yamamoto +9 more
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Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management
Advanced Science, EarlyView.ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak +9 more
wiley +1 more source
Immunological Synapse in the Biology of Chronic Lymphocytic Leukemia
Клиническая онкогематология, 2018 Chronic lymphocytic leukemia (CLL) is a lymphoproliferative disease manifested by accumulation of tumor B-cells with characteristic immunophenotype (CD19+CD5+CD23+) in bone marrow, peripheral blood and secondary lymphoid organs.
Darima Semunkoevna Badmazhapova +2 more
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