Results 101 to 110 of about 241,841 (240)

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Distinct dendritic cell cytoskeletal programs dictate synapse architecture and CD8+ T cell fate

Frontiers in Immunology
Dendritic cell activation of CD8+ T cells at the immunological synapse is critical for immunity, but the structural organization of the dendritic cell side and its impact on T cell fate remain poorly defined.
Camille D. Clamagirand, Camille D. Clamagirand, Christoph Ratswohl, Christoph Ratswohl, Marc W. Schmid, Theresia Eich, Nadine Anslinger, Nadine Anslinger, Daniel F. Legler, Daniel F. Legler, Daniel F. Legler, Daniel F. Legler, Jérémie Rossy, Jérémie Rossy   +13 more
doaj   +1 more source

Coordination of T cell activation and migration through formation of the immunological synapse.

, 2003
T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse.
MICHAEL L. DUSTIN
core   +1 more source

Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse [PDF]

, 2013
The centrosome is essential for cytotoxic T lymphocyte (CTL) function, contacting the plasma membrane and directing cytotoxic granules for secretion at the immunological synapse.
Earnshaw, CH, Dinsmore, Colin, Dinsmore, C, Griffiths, Gillian M, Ritter, Alex T, Reiter, Jeremy F, Ritter, AT, de la Roche, Maike, Reiter, JF, de, la Roche M, Angus, Karen L, Griffiths, GM, Earnshaw, Charles H, Angus, KL   +13 more
core   +1 more source

Three-Dimensional single molecule localization microscopy reveals the topography of the immunological synapse at isotropic precision below 15 nm

, 2021
T-cells engage with antigen-presenting cells in search for antigenic peptides and form transient interfaces termed immunological synapses. Synapse topography affects receptor binding rates and the mutual segregation of proteins due to size exclusion ...
Dustin, Michael L.; orcid:, Brameshuber, Mario; orcid:, Schütz, Gerhard J.; orcid:, Jesacher, Alexander, Kurz, Elke, Zelger, Philipp, Velas, Lukas, Huppa, Johannes B.   +7 more
core   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source

T cell antigen receptor signaling and immunological synapse stability require myosin IIA.

, 2009
Immunological synapses are initiated by signaling in discrete T cell antigen receptor microclusters and are important for the differentiation and effector functions of T cells.
Tal Ilani, Santosh Vardhana, Michael L Dustin, Gaia Vasiliver-Shamis, Anthony Bretscher   +4 more
core   +1 more source

Cellular Mechanisms Enabling Mitochondria Transfer and Transplantation

Advanced Science, EarlyView.
Mitochondrial transfer and transplantation (mitoTT) is examined as a multistep process governed by distinct transfer routes and post‐transfer checkpoints. Mechanisms controlling mitochondrial uptake, network integration, cristae remodeling, mtDNA maintenance, immune sensing, and quality control are highlighted, revealing key biological and ...
F. Seyma Gokdemir, Yagmur Ozendi, Gokhan Burcin Kubat, Keshav K. Singh   +3 more
wiley   +1 more source

Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse

Clinical and Developmental Immunology, 2013
To circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill
Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis   +5 more
doaj   +1 more source

The immunological synapse balances T cell receptor signaling and degradation.

, 2003
The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over ...
Andrey S. Shaw, Paul M. Allen, Gabriele Campi, Julia Wang, Osami Kanagawa, Kyeong-Hee Lee, Michael L. Dustin, Subhadip Raychaudhuri, W. Richard Burack, Arup K. Chakraborty, Aaron R. Dinner, Tasha N. Sims, Rajat Varma, Chun Tu, Hui Wu, Mary Markiewicz   +15 more
core   +1 more source