Results 101 to 110 of about 52,207 (332)
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Hybrid spreading mechanisms and T cell activation shape the dynamics of HIV-1 infection [PDF]
, 2015 HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts.
Borrow, Persephone +7 more
core +4 more sources
Transcriptomic and Neuroimaging Decoding of Brain‐Immune Crosstalk in Thyroid Eye Disease
Advanced Science, EarlyView.This study employed an imaging transcriptomics framework integrating resting‐state fMRI with Allen Human Brain Atlas transcriptomic data, coupled with peripheral blood RNA sequencing, to decode brain‐immune crosstalk in thyroid eye disease. Frontal, parietal, subcortical, and brainstem regions were identified as key neuroimmune‐ vulnerable regions ...
Haiyang Zhang +15 more
wiley +1 more source
Intercellular transfer of oncogenic H-Ras at the immunological synapse.
PLoS ONE, 2007 Immune cells establish dynamic adhesive cell-cell interactions at a specific contact region, termed the immunological synapse (IS). Intriguing features of the IS are the formation of regions of plasma membrane fusion and the intercellular exchange of ...
Oded Rechavi +4 more
doaj +1 more source
CD28 between tolerance and autoimmunity: The side effects of animal models [version 1; referees: 2 approved] [PDF]
, 2018 Regulation of immune responses is critical for ensuring pathogen clearance and for preventing reaction against self-antigens. Failure or breakdown of immunological tolerance results in autoimmunity.
A Aruffo +57 more
core +2 more sources
Advanced Science, EarlyView.This study presents a wireless, non‐invasive strategy for neural repair by developing a biodegradable piezoelectric dural patch that, under transcranial ultrasound, generates localized electrical fields to drive endogenous neural stem cells toward neuronal differentiation and functional integration.
Pengbo Zhou +7 more
wiley +1 more source
Human T-cell receptor triggering requires inactivation of Lim kinase-1 by Slingshot-1 phosphatase
Communications BiologyActin dynamics control early T-cell receptor (TCR) signalling during T-cell activation. However, the precise regulation of initial actin rearrangements is not completely understood.
Álvaro Gómez-Morón +13 more
doaj +1 more source
Flotillins are involved in the polarization of primitive and mature hematopoietic cells.
PLoS ONE, 2009 BackgroundMigration of mature and immature leukocytes in response to chemokines is not only essential during inflammation and host defense, but also during development of the hematopoietic system.
Lawrence Rajendran +7 more
doaj +1 more source
Kupfer-type immunological synapses in vivo : Raison D'être of SMAC [PDF]
, 2015 T cells engage with antigen-presenting cells to form immunological synapses. These intimate contacts are characterized by the complex arrangement of molecules at the intercellular interface, which has been described as the supramolecular activation ...
Barcia, Carlos +2 more
core +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Griscelli Syndrome Type 2 (GS2) is a rare autosomal recessive disorder caused by pathogenic mutations in the RAB27A gene. Typically, it is characterized by cutaneous hypopigmentation, immunodeficiency, with or without neurological abnormalities secondary to hemophagocytic lymphohistiocytosis (HLH). Without treatment, GS2 often results in fatal
Dzhoy Papingi +6 more
wiley +1 more source