Results 101 to 110 of about 565,531 (300)
Xenogeneic Mitochondrial Transplantation Improves Selected Age‐Associated Phenotypes in Mice
Advanced Science, EarlyView.Yak‐derived xenogeneic mitochondrial transplantation improves selected age‐associated phenotypes in mice, enhances mitochondrial functional readouts, and engages host mitochondrial quality‐control pathways. Broad tissue biodistribution, increased ATP production and mtDNA copy number, reduced ROS levels and dysfunctional mitochondria, improved motility ...
Wenpeng Li +5 more
wiley +1 more source
Integrins Modulate T Cell Receptor Signaling by Constraining Actin Flow at the Immunological Synapse
Frontiers in Immunology, 2018 Full T cell activation requires coordination of signals from multiple receptor–ligand pairs that interact in parallel at a specialized cell–cell contact site termed the immunological synapse (IS).
Katarzyna I. Jankowska +6 more
semanticscholar +1 more source
Diversity in immunological synapse structure
Immunology, 2010 SummaryImmunological synapses (ISs) are formed at the T cell–antigen‐presenting cell (APC) interface during antigen recognition, and play a central role in T‐cell activation and in the delivery of effector functions. ISs were originally described as a peripheral ring of adhesion molecules surrounding a central accumulation of T‐cell receptor (TCR ...
Timothy J, Thauland, David C, Parker
openaire +3 more sources
Advanced Science, EarlyView.We developed the ASCAL pipeline, integrating complementary spatial transcriptomics, to construct a high‐fidelity mouse whole‐eye single‐cell atlas. Applying ASCAL to a retinal artery occlusion (RAO) model revealed spatially restricted immune activation localized to the ganglion cell layer and the selective depletion of a translationally active, outer ...
Chen Du +11 more
wiley +1 more source
Understanding the structure and function of the immunological synapse.
, 2010 The immunological synapse has been an area of very active scientific interest over the last decade. Surprisingly, much about the synapse remains unknown or is controversial.
Shaw, AS +6 more
core +1 more source
WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts [PDF]
, 2015 The immunological synapse is a highly structured and molecularly dynamic interface between communicating immune cells. Although the immunological synapse promotes T cell activation by dendritic cells, the specific organization of the immunological ...
Nowosad, CR +20 more
core +1 more source
Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies
Advanced Science, EarlyView.In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang +4 more
wiley +1 more source
T cell receptor signaling precedes immunological synapse formation.
, 2002 The area of contact between a T cell and an antigen-presenting cell (APC) is known as the immunological synapse. Although its exact function is unknown, one model suggests that it allows for T cell receptor (TCR) clustering and for sustained signaling in
Shaw, AS +5 more
core +1 more source
Annual Review of Immunology, 2018 The engagement of a T cell with an antigen-presenting cell (APC) or activating surface results in the formation within the T cell of several distinct actin and actomyosin networks.
J. Hammer +3 more
semanticscholar +1 more source
Effective Membrane Model of the Immunological Synapse [PDF]
Physical Review Letters, 2003 6 pages, 3 figures, submitted for ...
Raychaudhuri, Subhadip +2 more
openaire +3 more sources