Results 111 to 120 of about 226,715 (279)

The Immunological Synapse--a Multitasking System

Science, 2002
The immunological synapse, the interface between the T cell and antigen-presenting cell (APC), is thought to be important for enhancing and sustaining signaling by the T cell receptor after it has engaged antigenic peptide on the APC surface. In a Perspective, van der Merwe and Davis discuss new findings ( Lee et al.) demonstrating ...
Van Der Merwe, P, Davis, S
openaire   +2 more sources

Interplay of channels, pumps and organelle location in calcium microdomain formation

New Journal of Physics, 2013
To analyze the influence of Ca ^2+ microdomains on the global cytosolic Ca ^2+ concentration, we consider the polarization and activation of T-cells after the formation of an immunological synapse as a model system.
Martin Peglow, Barbara A Niemeyer, Markus Hoth, Heiko Rieger   +3 more
doaj   +1 more source

The dendritic cell synapse: a life dedicated to T cell activation

Frontiers in Immunology, 2016
T cell activation within immunological synapses is a complex process whereby different types of signals are transmitted from antigen presenting cells to T cells.
Federica eBenvenuti
doaj   +1 more source

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Testing the organization of the immunological synapse [PDF]

Current Opinion in Immunology, 2007
Upon encounter with antigen-bearing presenting cells, T cells initiate the formation of a unique junction termed the immunological synapse (IS). The morphology of this junction, characterized in EM as a series of discrete contacts into which are interspersed synaptic spaces [1], has multiple similarities to neuronal synapses.
openaire   +2 more sources

The role of Protein Kinase Cη in T cell biology

Frontiers in Immunology, 2012
Protein kinase Cη (PKCη) is a member of the novel PKC subfamily, which also includes δ, ε, and θ isoforms. Compared to the other novel PKCs, the function of PKCη in the immune system is largely unknown.
Nicholas R.J. Gascoigne
doaj   +1 more source

WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts [PDF]

, 2015
The immunological synapse is a highly structured and molecularly dynamic interface between communicating immune cells. Although the immunological synapse promotes T cell activation by dendritic cells, the specific organization of the immunological ...
Nowosad, CR, Bouma, G, Malinova, Dessislava; id_orcid, Blundell, MP, Bouma, Gerben, Malinova, D, Fritzsche, M, Armer, Hannah, Nowosad, Carla R., Munro, Peter M.G., Fritzsche, Marco, Tolar, Pavel, Munro, PM, Charras, G, Tolar, P, Munro, PMG, Thrasher, Adrian J., Thrasher, AJ, Armer, H, Blundell, Michael P., Charras, Guillaume   +20 more
core   +1 more source

Reversing Macrophage Immunometabolic Dysfunction in Prolonged Infections Via a Glutaminolysis‐Fueled Restoration‐Based Hierarchically Selective Therapeutic System

Advanced Science, EarlyView.
A hierarchically selective immunotherapeutic nanoplatform, mGls@HEV‐MTP, selectively restores macrophage immunocompetence through GLS1‐mediated restoration of glutaminolysis‐fueled anaplerosis. Concurrently, it renders Staphylococcus aureus (S. aureus) more readily recognizable to the metabolically reprogrammed macrophages, thereby facilitating ...
Weinan Yang, Zihao An, Honglu Cai, Congsun Li, Jiaxuan Zou, Wushi Cui, Wentao Chen, Tao Zhang, Shicheng Wang, Zizhan Su, Jian Xiao, Tao Sun, Bin Hu, Min Cheng, Zhongru Gou, Jianbin Xu, An Liu, Haobo Wu   +17 more
wiley   +1 more source

Expansion Microscopy Reveals the Spatial Association of Therapeutic Antibody–Receptor Complexes With Cholesterol‐Rich Membrane Domains

Angewandte Chemie, EarlyView.
We report a super‐resolution strategy that maps cholesterol‐rich membrane domains in whole, intact cells with an effective spatial resolution of ∼40 nm by combining expansion microscopy with a perfringolysin O domain 4 probe. This approach enables direct visualization of the spatial association between CD20 and CD38 complexes and cholesterol‐rich ...
Gang Wen, Nicole Seifert, Patrick Eiring, Johanna Meyer, Hannes Neuweiler, Julia Weingart, Ignacio Vega‐Vásquez, Sören Doose, Philip Kollmannsberger, Markus Sauer   +9 more
wiley   +2 more sources

Distinct dendritic cell cytoskeletal programs dictate synapse architecture and CD8+ T cell fate

Frontiers in Immunology
Dendritic cell activation of CD8+ T cells at the immunological synapse is critical for immunity, but the structural organization of the dendritic cell side and its impact on T cell fate remain poorly defined.
Camille D. Clamagirand, Camille D. Clamagirand, Christoph Ratswohl, Christoph Ratswohl, Marc W. Schmid, Theresia Eich, Nadine Anslinger, Nadine Anslinger, Daniel F. Legler, Daniel F. Legler, Daniel F. Legler, Daniel F. Legler, Jérémie Rossy, Jérémie Rossy   +13 more
doaj   +1 more source