Results 111 to 120 of about 52,207 (332)
Synapse-directed delivery of immunomodulators using T-cell-conjugated nanoparticles [PDF]
, 2012 Regulating molecular interactions in the T-cell synapse to prevent autoimmunity or, conversely, to boost anti-tumor immunity has long been a goal in immunotherapy.
Bak, Peter +4 more
core +1 more source
What Counts in the Immunological Synapse? [PDF]
Molecular Cell, 2014 Molecular interactions at the interface between helper T cells and antigen-presenting B cells govern the ability to produce specific antibodies, which is a central event in protective immunity generated by natural infection or man-made vaccines. In order for a T cell to deliver effective help to a B cell and guide affinity maturation, it needs to ...
openaire +3 more sources
Annals of Neurology, EarlyView.Objective To characterize Fc‐glycosylation profiles in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis (NMDARe) and assess their association with antibody compartmentalization (cerebrospinal fluid [CSF] vs serum), disease triggers (viral, tumor‐related or idiopathic), and 1‐year outcomes.
Laura Marmolejo +16 more
wiley +1 more source
Journal of Imaging, 2019 Total internal reflection fluorescence microscopy with polarized excitation (P-TIRF) can be used to image nanoscale curvature phenomena in live cells. We used P-TIRF to visualize rat basophilic leukemia cells (RBL-2H3 cells) primed with fluorescent anti ...
Rosa Machado +4 more
doaj +1 more source
Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia. [PDF]
, 2016 Autism (AUT), schizophrenia (SCZ) and bipolar disorder (BPD) are three highly heritable neuropsychiatric conditions. Clinical similarities and genetic overlap between the three disorders have been reported; however, the causes and the downstream effects ...
Arking, DE +3 more
core +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped due to side‐effects in the joints. Knowledge about the biological effects of NGF on joint tissues is limited.
Alia M. Obeidat +14 more
wiley +1 more source
Interplay of channels, pumps and organelle location in calcium microdomain formation
New Journal of Physics, 2013 To analyze the influence of Ca ^2+ microdomains on the global cytosolic Ca ^2+ concentration, we consider the polarization and activation of T-cells after the formation of an immunological synapse as a model system.
Martin Peglow +3 more
doaj +1 more source
The dendritic cell synapse: a life dedicated to T cell activation
Frontiers in Immunology, 2016 T cell activation within immunological synapses is a complex process whereby different types of signals are transmitted from antigen presenting cells to T cells.
Federica eBenvenuti
doaj +1 more source
The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary
Autism Research, EarlyView.ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source