Results 131 to 140 of about 565,531 (300)
Protein & Cell, 2017 Cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells contribute to the body’s immune defenses. Current chimeric antigen receptor (CAR)-modified T cell immunotherapy shows strong promise for treating various cancers and infectious diseases ...
Dongfang Liu +6 more
semanticscholar +1 more source
Costimulation: Building an Immunological Synapse
Science, 1999 Immune responses are triggered by activation of the T cell receptor with foreign antigen. Dustin summarizes in his Perspective new evidence that this triggering event is actually the formation of an "immunological synapse," an area of close contact between cells. Recent results ( Viola et al.
Dustin, M, Shaw, A
openaire +2 more sources
Arthritis &Rheumatology, EarlyView.Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat +14 more
wiley +1 more source
Coordination of T cell activation and migration through formation of the immunological synapse.
, 2003 T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse.
Dustin, ML +2 more
core +1 more source
Quantitative Imaging Approaches to Study the CAR Immunological Synapse.
Molecular Therapy, 2017 The lytic immunological synapse (IS) is a discrete structural entity formed after the ligation of specific activating receptors that leads to the destruction of a cancerous cell.
M. Mukherjee +4 more
semanticscholar +1 more source
New opportunities for bioscaffold‐enabled spinal cord injury repair
BMEMat, EarlyView.Schematic illustration of bioscaffolds for spinal cord injury repair. We summarize the effects of bioscaffold properties on SCI repair, highlight different types of bioscaffolds, various fabrication strategies, and in vivo transformations for the clinical development of SCI‐repairing bioscaffolds.
Xiaoqing Qi +11 more
wiley +1 more source
Distinct dendritic cell cytoskeletal programs dictate synapse architecture and CD8+ T cell fate
Frontiers in ImmunologyDendritic cell activation of CD8+ T cells at the immunological synapse is critical for immunity, but the structural organization of the dendritic cell side and its impact on T cell fate remain poorly defined.
Camille D. Clamagirand +13 more
doaj +1 more source
A Predetermined Site for The Immunological Synapse [PDF]
, 2015 Background Over the last 30 years there has been great advances in understanding the interaction between T cells and antigen presenting cells (APCs).
Roalsø, Marcus Thomas Thor
core
Cutting edge: quantitative imaging of raft accumulation in the immunological synapse.
, 2002 Although the accumulation of lipid rafts at the immunological synapse is now well accepted, the degree of the accumulation, the localization within the fine structure of the immunological synapse, and the region from which lipid rafts are recruited have ...
Shaw, AS +4 more
core +1 more source
Front. Cell Dev. Biol., 2018 The immunological synapse (IS) is a specialized structure that serves as a platform for cell-cell communication between a T cell and an antigen-presenting cell (APC).
Nathan H. Roy, J. Burkhardt
semanticscholar +1 more source