Results 121 to 130 of about 226,715 (279)
The dendritic cell side of the immunological synapse: exploring terra incognita
, 2009 5 p.The activation and clonal expansion of naive T cells by antigen-loaded dendritic cells (DCs) in the lymph nodes is a key event during immune response.
Delgado-Martín, Cristina +3 more
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CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation
Advanced Science, EarlyView.CAR‐engineered cell therapies are expanding beyond cancer toward immune resetting, pathological‐cell clearance, matrix remodeling, and microenvironmental reprogramming in autoimmune, inflammatory, and fibrotic diseases. This Review compares CAR‐T, CAR‐macrophage, and CAR‐NK platforms and proposes controllable spatiotemporal reprogramming to align ...
Peng Jun Xu +6 more
wiley +1 more source
Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse
Clinical and Developmental Immunology, 2013 To circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill
Pablo A. González +5 more
doaj +1 more source
A Predetermined Site for The Immunological Synapse [PDF]
, 2015 Background Over the last 30 years there has been great advances in understanding the interaction between T cells and antigen presenting cells (APCs).
Roalsø, Marcus Thomas Thor
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Coordination of T cell activation and migration through formation of the immunological synapse.
, 2003 T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse.
Dustin, ML +2 more
core +1 more source
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Cutting edge: quantitative imaging of raft accumulation in the immunological synapse.
, 2002 Although the accumulation of lipid rafts at the immunological synapse is now well accepted, the degree of the accumulation, the localization within the fine structure of the immunological synapse, and the region from which lipid rafts are recruited have ...
Shaw, AS +4 more
core +1 more source
Advanced Science, EarlyView.TPBE scaffolds, in conjunction with mild photothermal effects, effectively activate the PI3K/Akt signaling cascade, thereby promoting early neuronal differentiation and neurite growth. Short‐term (12 W) in vivo implantation studies revealed no significant pathological damage to major organs, providing preliminary evidence of the material's excellent ...
Bingqian Wang +8 more
wiley +1 more source
The immunological synapse balances T cell receptor signaling and degradation.
, 2003 The immunological synapse is a specialized cell-cell junction between T cell and antigen-presenting cell surfaces. It is characterized by a central cluster of antigen receptors, a ring of integrin family adhesion molecules, and temporal stability over ...
Andrey S. Shaw +32 more
core +1 more source
Identification and characterization of cell adhesion molecules controlling synapse stability [PDF]
, 2012 Neuronal circuits form the basis of a functional nervous system to process and integrate information and to react to environmental cues. The formation of functional synaptic connections between neurons is essential for the establishment of these circuits.
Enneking, Eva-Maria
core +1 more source