Results 121 to 130 of about 565,531 (300)

Stomatin-like Protein 2 Links Mitochondria to T-Cell Receptor Signalosomes at the Immunological Synapse and Enhances T-Cell Activation

, 2007
T cell activation through the antigen receptor (TCR) requires sustained signalling from microclusters in the peripheral region of the immunological synapse (IS).
Joaquin Madrenas, Maria E. Marquez, Mark G. Kirchhof, Isaac Blaca, Peter J. Darlington, Santosh Vardhana, Luan A. Chau, Roy Taylor, Caitlin D. Lemke, Kamilia Rizkalla, Michael L. Dustin   +10 more
core  

Boltzmann energy-based image analysis demonstrates that extracellular domain size differences explain protein segregation at immune synapses [PDF]

, 2011
Immune synapses formed by T and NK cells both show segregation of the integrin ICAM1 from other proteins such as CD2 (T cell) or KIR (NK cell).
Dustin, Michael L., van der Merwe P. Anton, Nigel J Burroughs, Michael L Dustin, Van Der Merwe, PA, P Anton van der Merwe, Nigel J. Burroughs, Miloserdov, Vladimir, Van der Merwe, P. Anton, Miloserdov, V, Davis, DM, Dustin, ML, Daniel M Davis, Daniel M. Davis, Davis Daniel M., Köhler, K, Michael L. Dustin, Miloserdov Vladimir, Karsten Köhler, Dustin, Michael, Burroughs Nigel J., Dustin Michael L., Burroughs, Nigel J., P. Anton van der Merwe, Davis, Daniel M., Burroughs, NJ, Köhler Karsten, Van Der Merwe, Philip, Köhler, Karsten, Burroughs, Nigel John, Vladimir Miloserdov   +30 more
core   +1 more source

Simultaneous Depression of Immunological Synapse and Endothelial Injury is Associated with Organ Dysfunction in Community-Acquired Pneumonia

Journal of Clinical Medicine, 2019
Rationale: A depressed expression of antigen presentation is, along with endothelial dysfunction, a recognized signature of severe community-acquired pneumonia (CAP).
R. Menéndez, R. Méndez, R. Almansa, A. Ortega, R. Alonso, M. Suescún, A. Ferrando, L. Feced, J. Bermejo-Martín   +8 more
semanticscholar   +1 more source

Modulation of Tumor Immunity by Soluble and Membrane-Bound Molecules at the Immunological Synapse

Clinical and Developmental Immunology, 2013
To circumvent pathology caused by infectious microbes and tumor growth, the host immune system must constantly clear harmful microorganisms and potentially malignant transformed cells. This task is accomplished in part by T-cells, which can directly kill
Pablo A. González, Leandro J. Carreño, Pablo F. Céspedes, Susan M. Bueno, Claudia A. Riedel, Alexis M. Kalergis   +5 more
doaj   +1 more source

Imaging Membrane Curvature inside a FcεRI-Centric Synapse in RBL-2H3 Cells Using TIRF Microscopy with Polarized Excitation

Journal of Imaging, 2019
Total internal reflection fluorescence microscopy with polarized excitation (P-TIRF) can be used to image nanoscale curvature phenomena in live cells. We used P-TIRF to visualize rat basophilic leukemia cells (RBL-2H3 cells) primed with fluorescent anti ...
Rosa Machado, Justin Bendesky, Madison Brown, Kathrin Spendier, Guy M. Hagen   +4 more
doaj   +1 more source

Developing T cells form an immunological synapse for passage through the β−selection checkpoint

bioRxiv, 2019
The β-selection checkpoint of T cell development tests whether the cell has recombined its genomic DNA to produce a functional T Cell Receptor β (TCRβ) receptor.
Amr H. Allam, M. Charnley, K. Pham, S. Russell   +3 more
semanticscholar   +1 more source

Role of Drebrin at the Immunological Synapse [PDF]

, 2017
Although drebrin was first described in neurons, it is also expressed in cells of the immune system, such as T lymphocytes and mast cells. Another member of the drebrin family of proteins, mammalian actin-binding protein 1 (mAbp-1) is more widely expressed and plays important roles in the function of macrophages, polymorphonuclear neutrophils, and B ...
Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid   +2 more
openaire   +3 more sources

Genetic‐Proteomic Integration Identifies Predictive Plasma Proteins for Multiple Sclerosis

Annals of Neurology, EarlyView.
Objective Multiple sclerosis (MS) develops after a prolonged preclinical phase. Identifying circulating biomarkers that capture this early biology can improve risk stratification and guide intervention. We aimed to identify plasma proteins driving MS susceptibility using large‐scale proteogenomic integration and to evaluate their prediagnostic ...
Yuan Ding, Dylan Hamitouche, Simon Thebault, Patrick Kearns, Ahmed Abdelhak, Adil Harroud   +5 more
wiley   +1 more source

Interplay of channels, pumps and organelle location in calcium microdomain formation

New Journal of Physics, 2013
To analyze the influence of Ca ^2+ microdomains on the global cytosolic Ca ^2+ concentration, we consider the polarization and activation of T-cells after the formation of an immunological synapse as a model system.
Martin Peglow, Barbara A Niemeyer, Markus Hoth, Heiko Rieger   +3 more
doaj   +1 more source

The dendritic cell synapse: a life dedicated to T cell activation

Frontiers in Immunology, 2016
T cell activation within immunological synapses is a complex process whereby different types of signals are transmitted from antigen presenting cells to T cells.
Federica eBenvenuti
doaj   +1 more source