Results 151 to 160 of about 565,531 (300)

The dendritic cell side of the immunological synapse: exploring terra incognita

, 2009
5 p.The activation and clonal expansion of naive T cells by antigen-loaded dendritic cells (DCs) in the lymph nodes is a key event during immune response.
Delgado-Martín, Cristina, Riol-Blanco, Lorena, Rodríguez-Fernández, José Luis, Escribano, Cristina   +3 more
core  

Actin clearance promotes polarized dynein accumulation at the immunological synapse

bioRxiv, 2018
Immunological synapse (IS) formation between a T cell and an antigen-presenting cell is accompanied by the reorientation of the T cell centrosome toward the interface.
Elisa E. Sanchez, Xin Liu, M. Huse
semanticscholar   +1 more source

Identification of T:B Cell Multimers After Bispecific T Cell Engagement, Using Both Conventional and Imaging Flow Cytometry

Cytometry Part A, EarlyView.
ABSTRACT Bispecific T cell engagers bring together T cells with malignant B cell targets to enable synapse formation and disease eradication of hematological malignancies. The proportion of T cells and their ability to bind to their targets varies between patients and may be a biomarker of response.
Joanne E. Davis, Mandy Ludford‐Menting, Helena Peng, Darryl N. Johnson, David S. Ritchie, Rachel Koldej   +5 more
wiley   +1 more source

Modeling receptor-ligand binding kinetics in immunological synapse formation

, 2008
The formation of an immunological synapse between two immune cells is a central process in immunity allowing the exchange of information that is of direct relevance for the cells' activation states.
M. Meyer-Hermann, M. T. Figge
core   +1 more source

Hedgehog Signaling Controls T Cell Killing at the Immunological Synapse [PDF]

, 2013
The centrosome is essential for cytotoxic T lymphocyte (CTL) function, contacting the plasma membrane and directing cytotoxic granules for secretion at the immunological synapse.
Earnshaw, CH, Dinsmore, Colin, Dinsmore, C, Griffiths, Gillian M, Ritter, Alex T, Reiter, Jeremy F, Ritter, AT, de la Roche, Maike, Reiter, JF, de, la Roche M, Angus, Karen L, Griffiths, GM, Earnshaw, Charles H, Angus, KL   +13 more
core   +1 more source

Transcriptomic depression of immunological synapse as a signature of ventilator-associated pneumonia.

Annals of Translational Medicine, 2018
Background Ventilator-associated pneumonia (VAP) is one of the most commonly encountered intensive care unit (ICU) acquired infections worldwide. The objective of the study was to identify the immune alteration occurring in patients suffering from VAP at
R. Almansa, L. Nogales, M. Martín-Fernández, Montse Batlle, E. Villareal, Lucía Rico, A. Ortega, G. López-Campos, D. Andaluz-Ojeda, P. Ramírez, L. Socias, L. Tamayo, J. Vallés, J. Bermejo-Martín, I. Martín-Loeches   +14 more
semanticscholar   +1 more source

Evaluating the Potential Infectious Risk Profile of Biologics in Chronic Rhinosinusitis With Nasal Polyposis

International Forum of Allergy &Rhinology, EarlyView.
Maxime Fieux, Philippe Gevaert, Leigh J. Sowerby   +2 more
wiley   +1 more source

Pyruvate dehydrogenase autoantibodies in autoantibody‐negative patients with seizures are associated with reduced pyruvate dehydrogenase activity

Epilepsia, EarlyView.
Abstract Objective We investigated the presence and potential functional relevance of antimitochondrial autoantibodies in patients suspicious for autoimmune encephalitis (AIE) associated with psychiatric symptoms and/or seizures, who were negative for known antineuronal autoantibodies.
Annika Breuer, Chiara A. Hummel, Tobias Baumgartner, Juliane L. Berns, Afaf Milad Said, Isabel Bünger, Susanne Schoch, Gábor Zsurka, Harald Prüss, Wolfram S. Kunz, Rainer Surges, Albert J. Becker, Julika Pitsch   +12 more
wiley   +1 more source

CD28 interaction with filamin-A controls lipid raft accumulation at the T-cell immunological synapse

, 2006
During physiological T-cell stimulation by antigen presenting cells (APCs), a major T-cell membrane rearrangement is known to occur leading to the organization of 'supramolecular activation clusters' at the immunological synapse.
TUOSTO L, BARANDA SJ, CONTENTO RL, SOLIGO M, TAVANO, REGINA, MANES S, VIOLA, ANTONELLA   +6 more
core   +2 more sources

The tyrosine phosphatase SHP-1 promotes T cell adhesion by activating the adaptor protein CrkII in the immunological synapse

Science Signaling, 2017
Targeting the phosphorylation state of a T cell adaptor protein may enable modulation of T cell adhesion and activation. Shaping T cell activation Efficient activation of the T cell receptor (TCR) on T cells by antigen-presenting cells (APCs) requires ...
I. Azoulay-Alfaguter, Marianne Strazza, M. Peled, Hila K Novak, James Muller, Michael Loran Dustin, A. Mor   +6 more
semanticscholar   +1 more source