Results 171 to 180 of about 565,531 (300)

Impact of Mycobacterium tuberculosis Glycolipids on the CD4+ T Cell-Macrophage Immunological Synapse. [PDF]

J Immunol, 2023
Mwebaza I, Shaw R, Li Q, Fletcher S, Achkar JM, Harding CV, Carpenter SM, Boom WH.   +7 more
europepmc   +1 more source

Rapid recovery after intrathecal dexamethasone in FIRES

Epileptic Disorders, EarlyView.
João Filipe Nico, Ana Rita Fradique, Catarina Teixeira, Rita Moinho, Mariana Leitão Marques, Constança Santos, Joana Afonso Ribeiro, Filipe Palavra, Cristina Pereira   +8 more
wiley   +1 more source

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

B7-1 and B7-2 Selectively Recruit CTLA-4 and CD28 to the Immunological Synapse

, 2004
The reported affinity differences between CD28 and CTLA-4 binding to B7-1 and B7-2 may serve to selectively regulate CD28 and CTLA-4 function by differentially recruiting and/or stabilizing these molecules at the immunological synapse.
Wojnoonski, Kathleen, Allison, James P., Egen, Jackson G., Pentcheva-Hoang, Tsvetelina   +3 more
core   +1 more source

Immunomodulation of the Prostate Tumor Microenvironment Following Inorganic Arsenic Exposure

Journal of Applied Toxicology, EarlyView.
ABSTRACT The tumor microenvironment (TME) influences prostate cancer (PCa) progression through stromal and immune interactions. Adipose‐derived mesenchymal stromal cells (ASCs) modulate immune tone, while inorganic arsenic (iAs), a widespread toxicant, is linked to immune suppression and carcinogenesis.
Joseph J. Shearer, Cosette Rivera‐Cruz, Alexandre M. B. Cavalca, Carlos Eduardo Fonseca‐Alves, Marxa L. Figueiredo   +4 more
wiley   +1 more source

Polarized release of T-cell-receptor-enriched microvesicles at the immunological synapse.

, 2014
The recognition events that mediate adaptive cellular immunity and regulate antibody responses depend on intercellular contacts between T cells and antigen-presenting cells (APCs). T-cell signalling is initiated at these contacts when surface-expressed T-
Jaime Llodrá, Roth, EW, David L. Stokes, Llodrá, J, Susana Gordo, Gordo, S, Dustin, Michael, Kaushik Choudhuri, Wucherpfennig, KW, Kam, LC, Lance C. Kam, Kai W. Wucherpfennig, Jones Tsai, Stokes, DL, Dustin, ML, Choudhuri, K, Eric W. Roth, Tsai, J, Michael L. Dustin   +18 more
core   +1 more source

Evaluation of Soluble Triggering Receptor Expressed on Myeloid Cells 2 (sTREM2) in Cerebrospinal Fluid, Serum, and Plasma Using the Fully Automated Lumipulse Platform

Journal of Clinical Laboratory Analysis, EarlyView.
Relationship between serum and CSF sTREM2 concentration. ABSTRACT Background In this study, we first evaluated the relationship between sTREM2 concentrations in CSF, serum, and plasma of Alzheimer's disease (AD) patients using the newly developed Lumipulse G sTREM2 assay.
Luisa Agnello, Anna Maria Ciaccio, Fabio Del Ben, Caterina Maria Gambino, Tommaso Piccoli, Mauro Midiri, Concetta Scazzone, Anna Masucci, Martina Tamburello, Marcello Ciaccio   +9 more
wiley   +1 more source

Correlation of a dynamic model for immunological synapse formation with effector functions: two pathways to synapse formation.

, 2002
During antigen recognition by T cells different receptors and ligands form a pattern in the intercellular junction called the immunological synapse, which might be involved in T-cell activation. Recently, a synapse assembly model has been proposed, which
Yuko Hori, Lee, SJ, Groves, JT, Hori, Y, Michael L Dustin, Chakraborty, AK, Dustin, ML, Sung-Joo E Lee, Jay T Groves, Arup K Chakraborty, Dustin, Michael   +10 more
core   +1 more source

The Laryngeal Auditory Startle Reflex (LASR): A New Component of the Auditory Startle Response

The Laryngoscope, EarlyView.
The auditory startle reflex contains a distinct laryngeal component, termed the laryngeal auditory startle reflex (LASR). In healthy adults, the LASR is modulated by supratentorial influences and habituates to repetitive stimuli. Physiologic and pathologic implications for the LASR as a component of the overall human SR remain to be determined but may ...
Catherine F. Sinclair, Maria J. Tellez, Paola M. Rodriguez Morel, Patricia Torralba, Sedat Ulkatan   +4 more
wiley   +1 more source