Results 181 to 190 of about 226,715 (279)

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Actomyosin rings constrain CD40 mobility to organize the dendritic cell immunological synapse. [PDF]

Cell Commun Signal
Clamagirand CD, Mallet E, Nieves DJ, Ratswohl C, Owen DM, Rossy J.   +5 more
europepmc   +1 more source

Corrigendum: WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells. [PDF]

Front Cell Dev Biol, 2022
Li Y, Bhanja A, Upadhyaya A, Zhao X, Song W.   +4 more
europepmc   +1 more source

Serum elemental profile‐based machine learning models for Alzheimer's disease identification and cognitive score prediction

Neuroprotection, EarlyView.
Serum elemental profiling combined with machine learning supports exploratory Alzheimer's disease (AD) identification and cognitive score prediction. In this retrospective cross‐sectional study, 874 participants from the BANC‐PUMC, including cognitively normal controls and patients with AD, were analyzed.
Haotian Liu, Xinnan Liu, Yashuang Chen, Meng Pan, Ying Fu, Chao Ma, Wei Ge   +6 more
wiley   +1 more source

An integrated workflow for phosphopeptide identification in natural killer cells (NK-92MI) and their targets (MDA-MB-231) during immunological synapse formation. [PDF]

STAR Protoc, 2023
Perez-Hernandez D, Filali L, Thomas C, Dittmar G.   +3 more
europepmc   +1 more source

Restoration, Not Bypass: Otoferlin Gene Therapy and a New Era in Hearing Loss Treatment

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract The FDA approval of Otarmeni, an AAV‐based gene therapy for biallelic OTOF‐associated sensorineural hearing loss, represents a conceptual shift in otology: from bypassing defective auditory physiology to restoring it. Unlike cochlear implantation, which circumvents damaged sensory structures, OTOF gene replacement targets a synaptic deficit in
Jazlyn A. Selvasingh, Justin R. Shinn
wiley   +1 more source

T cell stiffness is enhanced upon formation of immunological synapse. [PDF]

Elife, 2021
Jung P, Zhou X, Iden S, Bischoff M, Qu B.   +4 more
europepmc   +1 more source

Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome

PROTEOMICS, EarlyView.
ABSTRACT Disease‐related activation of glial cells leads to changes in the cerebrospinal fluid (CSF) proteome. However, assigning such protein changes to their cellular origins is often difficult. Here, we used microglia (and macrophage) depletion in mice to identify CSF proteins of microglial origin.
Sinja Buchner, Sihui Song, Stephan A. Müller, Yun Chen, Samira Parhizkar, Stefan F. Lichtenthaler, David M. Holtzman, Mathias Jucker, Stephan A. Kaeser   +8 more
wiley   +1 more source

Actin waves guide an outward movement of microclusters in the lymphocyte immunological synapse. [PDF]

EMBO Rep
Dey A, Khiangte SZ, Mandal S, Colin-York H, Fritzsche M, Sarkar S, Kumari S.   +6 more
europepmc   +1 more source