Results 181 to 190 of about 241,841 (240)

YBX1 Promotes Malignant Progression of HNSCC via Stabilizing NSUN2‐m5C Modified ATF4 mRNA

Cancer Science, EarlyView.
The diagram depicts the core axis and the key finding: “Targeting YBX1/NSUN2 abrogates HNSCC progression”. Within left‐sided HNSCC cells, NSUN2 mediates m5C methylation on the CDS of ATF4 mRNA; YBX1 then specifically recognizes and binds this modified site, augmenting ATF4 mRNA stability, which ultimately promotes cancer cell proliferation, migration ...
Yanwei Li, Shuang Li, Yang Li, Zhanyu Pan   +3 more
wiley   +1 more source

Lipid switches in the immunological synapse. [PDF]

J Biol Chem
Griffiths G, Brügger B, Freund C.
europepmc   +1 more source

Lung Cancer Brain Metastasis: Brain Microenvironmental Adaptation, Therapeutic Resistance and Translational Strategies

Cancer Science, EarlyView.
Lung cancer brain metastasis is shaped by dynamic crosstalk among tumor cells, the blood–brain barrier, glial and immune cells, neurons, and metabolic niches. This review integrates these mechanisms with therapeutic resistance, translational models, CNS delivery, and multidisciplinary treatment strategies.
Jun Yang, Junyi Xiong, Li Ying, Yanyang Zeng, Ziqiang Ouyang, Mei Liu, Meihua Li   +6 more
wiley   +1 more source

Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse. [PDF]

Proc Natl Acad Sci U S A
Hoffmann C, Filali L, Wurzer H, Pereira Fernandes D, Mgrditchian T, Huang W, Moreau F, Krecké M, Thomas C.   +8 more
europepmc   +1 more source

WASp Is Crucial for the Unique Architecture of the Immunological Synapse in Germinal Center B-Cells. [PDF]

Front Cell Dev Biol, 2021
Li Y, Bhanja A, Upadhyaya A, Zhao X, Song W.   +4 more
europepmc   +1 more source

EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect

Cancer Science, EarlyView.
Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu, Jingjia Chang, Zhiyong Li, Jin Wu, Pengfei Yu, Jingjing Zheng, Li Li, Jia Tao, Hao Wu, Yintao Li, Ming Liu   +10 more
wiley   +1 more source

Is the tumor cell side of the immunological synapse a polarized secretory domain? [PDF]

Front Immunol
Biolato AM, Filali L, Pereira Fernandes D, Moreau F, Mgrditchian T, Hoffmann C, Thomas C.   +6 more
europepmc   +1 more source

The Serotonergic and Cholinergic Signaling Pathways Drive Gastric Precancerous Lesions and Its Potential Mechanism

Cancer Science, EarlyView.
Vagal cholinergic neurons promote gastric 5‐HT secretion, which drives gastric precancerous lesions through 5‐HTR1D and TRPV4, highlighting these as candidate targets for early intervention. ABSTRACT Gastric cancer (GC) is a leading lethal malignancy globally. Gastric precancerous lesion (GPL) represents a critical step in GC, but its neural regulatory
Shengli Gao, Xufei Feng, Nana Zhang, Jia Su, Yuyan Wang, Linghan Kong, Jianing Zhou, Hui Dong, Feifei Guo   +8 more
wiley   +1 more source

PDZ domains of PATJ facilitate immunological synapse formation to promote T cell activation. [PDF]

J Immunother Cancer
Xiong X, Wang D, Xu L, Chen S, He J, Zhang X, Fang Z, Zhang J, Li W, Zhou P.   +9 more
europepmc   +1 more source

Role of Actin Cytoskeleton Reorganization in Polarized Secretory Traffic at the Immunological Synapse. [PDF]

Front Cell Dev Biol, 2021
Calvo V, Izquierdo M.
europepmc   +1 more source