Results 201 to 210 of about 241,841 (240)

Immune proteomic associations with indices of cortical development in 5‐year‐old children

Journal of Anatomy, EarlyView.
Typically developing 5‐year‐old children (n = 101–126) from the FinnBrain Birth Cohort Study, Finland, underwent both targeted serum immune proteomics and magnetic resonance brain imaging. Multiple inflammatory markers, from one cluster of co‐expressed immune proteins, were negatively associated with indices of cortical development, including thickness,
Aaron Barron, Aylin Rosberg, Jetro J. Tuulari, Minna Lukkarinen, Harri Merisaari, Eero Silver, Venla Kumpulainen, Anni Copeland, Ekaterina Saukko, Alex M. Dickens, Matej Oresic, Tuulia Hyötylainen, Linnea Karlsson, Hasse Karlsson, Isabella L. C. Mariani Wigley, Elmo P. Pulli   +15 more
wiley   +1 more source

Dynamics and spatial organization of Kv1.3 at the immunological synapse of human CD4+ T cells. [PDF]

Biophys J
Capera J, Jainarayanan A, Navarro-Pérez M, Valvo S, Demetriou P, Depoil D, Estadella I, Kvalvaag A, Felce JH, Felipe A, Dustin ML.   +10 more
europepmc   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Immunological synapse formation between T regulatory cells and cancer-associated fibroblasts promotes tumour development. [PDF]

Nat Commun
Varveri A, Papadopoulou M, Papadovasilakis Z, Compeer EB, Legaki AI, Delis A, Damaskou V, Boon L, Papadogiorgaki S, Samiotaki M, Foukas PG, Eliopoulos AG, Hatzioannou A, Alissafi T, Dustin ML, Verginis P.   +15 more
europepmc   +1 more source

Differential ubiquitin modifications of ESCRT‐I subunits VPS37‐1 and VPS28‐2 positively regulate plant immunity

New Phytologist, EarlyView.
The RING type ubiquitin ligase (E3), XBAT35.2, positively regulates FLS2‐mediated plant immunity against bacterial pathogens by modifying the ESCRT‐I subunits VPS28‐2 and VPS37‐1 with distinct ubiquitin chain types. Summary Sensing of pathogen‐associated molecular patterns (PAMPs) by pattern recognition receptors at the cell surface initiates the first
Chaofeng Wang, Yi Zhang, Bangjun Zhou, Pooja Verma, Lirong Zeng   +4 more
wiley   +1 more source

Inflammation and mechanical force‐induced bone remodeling

Periodontology 2000, EarlyView.
Abstract Periodontitis arises from imbalanced host–microbe interactions, leading to dysbiosis and destructive inflammation. The host's innate and adaptive immune responses produce pro‐inflammatory mediators that stimulate destructive events, which cause loss of alveolar bone and connective tissue attachment.
Hyeran Helen Jeon, Xin Huang, Leticia Rojas Cortez, Puttipong Sripinun, Jung‐me Lee, Julie J. Hong, Dana T. Graves   +6 more
wiley   +1 more source

From mouth to brain: Linking periodontal and peri‐implant dysbiosis to systemic inflammation and neuropathology

Periodontology 2000, EarlyView.
Abstract Background/Aim Growing evidence suggests that imbalances occurring within the human microbiota and deregulation of the host immune response may play a significant role in the development of neurodegenerative diseases. Materials and Methods A comprehensive narrative review of the latest experimental, clinical, and epidemiological insights was ...
Emilio A. Cafferata, Frank Schwarz, Jaime Díaz‐Zúñiga, Alpdogan Kantarci   +3 more
wiley   +1 more source

In the Midst of a Cytokine Storm—The Hemophagocytic Syndrome (Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome)

Veterinary Clinical Pathology, EarlyView.
ABSTRACT Background Hemophagocytic syndrome (HPS)/hemophagocytic lymphohistiocytosis (HLH) is a life‐threatening hyperinflammatory syndrome characterized by immune dysregulation, cytokine overproduction, hemophagocytosis, cytopenias, and multiorgan dysfunction.
Joanne B. Messick
wiley   +1 more source

A multi‐omics investigation of sarcopenia and frailty: Integrating genomic, epigenomic and telomere length data

Experimental Physiology, EarlyView.
Abstract Sarcopenia and frailty are complex geriatric syndromes influenced by a combination of genetic and environmental factors. Recent studies suggest that specific genetic variants, DNA methylation patterns and shortened telomeres are associated with age‐related diseases and might contribute to the development of both sarcopenia and frailty. In this
Valentina Ginevičienė, Erinija Pranckevičienė, Alina Urnikytė, Laura Jurkūnaitė, Kristijona Gutauskaitė, Rūta Dadelienė, Justina Kilaitė, Ieva Eglė Jamontaitė, Asta Mastavičiūtė, Ildus I. Ahmetov, Vidmantas Alekna   +10 more
wiley   +1 more source