Results 221 to 230 of about 241,841 (240)

Disruption of Lactate Metabolism in the Peripheral Nervous System Leads to Motor‐Selective Deficits

Glia, Volume 74, Issue 12, December 2026.
To test the importance of lactate metabolism and shuttling between Schwann cells and neurons in the PNS, we selectively knocked out both LDHA and LDHB in motor neurons, sensory neurons, or Schwann cells. ABSTRACT Schwann cells (SCs) myelinate and provide trophic support to axons in the peripheral nervous system (PNS).
A. Joseph Bloom, Shweta Tendulkar, Amber R. Hackett, Amy Strickland, Yurie Sato‐Yamada, Liya Yuan, Wendy Dong, Joseph Ippolito, Robert E. Schmidt, Yo Sasaki, Aaron DiAntonio, Jeffrey Milbrandt   +11 more
wiley   +1 more source

Reframing the Gut–Brain Axis: The Gut Wall as a Neural Immune Interface in Multiple Sclerosis and Autoimmune Neurological Diseases

Annals of Neurology, Volume 100, Issue 5, Page 915-930, November 2026.
Gut wall physiology in multiple sclerosis (MS) and autoimmune neurologic diseases remains underexplored but may span gut barrier dysfunction, enteric glial targeting, mucosal immune dysregulation, and autoimmune targets within the enteric nervous system (ENS).
Federico Montini, Sean J. Pittock, Laura Cacciaguerra, Howard L. Weiner, Luke A. Schwerdtfeger   +4 more
wiley   +1 more source

Nerve Growth Factor is Sufficient to Cause Multiple Osteoarthritis‐Relevant Pathologic Features in Naïve Murine Knee Joints

Arthritis &Rheumatology, Volume 78, Issue 11, Page 2246-2260, November 2026.
Objective Nerve growth factor (NGF), a key mediator of pain, is increased in osteoarthritic (OA) joints. Antibodies against NGF show analgesic effects in painful knee OA, but clinical development was stopped because of side effects in the joints. Knowledge about the biologic effects of NGF on joint tissues is limited. Therefore, we explored the effects
Alia M. Obeidat, Michael D. Newton, Jun Li, Baofeng Hu, Shingo Ishihara, Lindsey Lammlin, Lucas M. Junginger, Easton C. Farrell, Lai Wang, Frank C. Ko, Richard J. Miller, Carla R. Scanzello, Tristan Maerz, Rachel E. Miller, Anne‐Marie Malfait   +14 more
wiley   +1 more source

Fecal Microbiota Transplantation: A Promising Therapeutic Strategy Targeting the Microbiota–Gut–Brain Axis in Anorexia Nervosa

Brain and Behavior, Volume 16, Issue 11, November 2026.
Gut dysbiosis in anorexia nervosa may impair microbiota–gut–brain signaling through metabolic, immune, and vagal pathways. Fecal microbiota transplantation is being investigated as a potential strategy to restore host–microbiome balance, support a healthier microbial composition, and improve gastrointestinal function, appetite, and mood.
Shawn L. Kwok, Yu‐Chen Xiao, Xian‐Bin Cai   +2 more
wiley   +1 more source

Diabetic Autonomic Neuropathy and Impaired Inflammatory Reflex

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
The cholinergic anti‐inflammatory pathway under normal and diabetic conditions. In the normal state, vagal activation through nicotinic acetylcholine receptors helps regulate immune responses and suppress excessive inflammation. In diabetes, impaired autonomic function and dysregulated cholinergic signalling weaken this anti‐inflammatory pathway ...
Narges Dastmalchi, Mohammad Amin Doustvandi, Reza Rahbarghazi, Khalil Hajiasgharzadeh   +3 more
wiley   +1 more source

Cancer Neuroscience: From Hallmark‐Enabling Biology to a Therapeutic Pillar

Advanced Oncology, Volume 1, Issue 1, December 2026.
Moran Amit
wiley   +1 more source

The Immunological Synapse

Annual Review of Immunology, 2001
The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an ...
Andrey Shaw, Mark M. Davis, Paul M Allen
exaly   +2 more sources

Formation and function of the immunological synapse

Current Opinion in Immunology, 2002
Less than five years ago it was reported that cell surface molecules at the contact site between CD4 T cells and antigen-presenting cells redistribute into distinct patterns, forming an organized interface termed the immunological synapse. More recently,
Anton van der Merwe
exaly   +2 more sources

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Harnessing the Formation of Natural Killer–Tumor Cell Immunological Synapses for Enhanced Therapeutic Effect in Solid Tumors

Advanced Materials, 2020
Junsang Doh, Junseok Lee, Won Jong Kim
exaly  

Immunological Synapse Predicts Effectiveness of Chimeric Antigen Receptor Cells

Molecular Therapy, 2018
Gianpietro Dotti, Dongfang Liu, Wei Xiong   +2 more
exaly