Results 211 to 220 of about 241,841 (240)

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Correction for Hoffmann et al., Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Transfer of paracetamol across the placenta and fetal blood–brain barriers and its safety for use in pregnancy

The Journal of Physiology, EarlyView.
Abstract figure legend Paracetamol (acetaminophen) is commonly taken during pregnancy for pain and fever. To gain a more comprehensive understanding of paracetamol's effects during pregnancy, several elements need to be examined including the transfer of paracetamol across the placenta and into the developing brain, the short‐ and long‐term effects of ...
Yifan Huang, Liam Koehn
wiley   +1 more source

Virus‐specific alterations in placental structure and transporter expression following maternal arbovirus infection

The Journal of Physiology, EarlyView.
Abstract figure legend Arboviruses induce virus‐specific alterations in placental structure and functional markers. Chikungunya virus (CHIKV) exposure was associated with reduced syncytiotrophoblast and syncytial knot areas, increased cytotrophoblast proliferation (Ki‐67) and thyroid transporter (MCT8) expression, reduced protective (P‐gp and BCRP ...
Cherley B. V. Andrade, Enrrico Bloise, Natália L. Silva, Jair R. S. Braga, Sharton V. A. Coelho, Veronica M. O. Nascimento, Guinever E. Imperio, Camila O. S. Nunes, Antônio J. L. A. Cunha, Marcelo A. Pascoal‐Xavier, Luciana B. Arruda, Arnaldo Prata‐Barbosa, Kristin L. Connor, Tania M. Ortiga‐Carvalho   +13 more
wiley   +1 more source

Scaling temporal resolution from mice to humans: Challenges and innovations in preclinical imaging of translational models

The Journal of Physiology, EarlyView.
Abstract figure legend Temporal scaling physiology differs significantly between mice and humans. Mice have higher metabolism, heart and respiratory rate, as well as faster blood flow rates, brain activity and physiological dynamics over time. These differences influence the temporal resolution needed in preclinical imaging of mouse models to ...
Sara Gargiulo, Matteo Gramanzini
wiley   +1 more source

Hypoxia‐induced vulnerability of the somatosensory nervous system

The Journal of Physiology, EarlyView.
Abstract figure legend Sensory neurons are highly energy dependent and rely on sufficient oxygen availability to maintain metabolic stability and effective neurocommunication. Within the somatosensory system, even modest reductions in tissue oxygen tension impair neuronal respiration, forcing a shift toward less efficient metabolic pathways that ...
Jack Corbett, Richard P. Hulse
wiley   +1 more source

Regional electrical differences and arrhythmia in the rat atria: Role of sympathetic nerve distribution and function

The Journal of Physiology, EarlyView.
Abstract figure legend Atrial fibrillation commonly develops in the left atrium and pulmonary veins (PVs), and can be triggered by sympathetic nerve activity. Here, we examined regional atrial differences in sympathetic nerve distribution and function in the rat.
James Saleeb‐Mousa, Manish Kalla, Neil Herring, Christopher O'Shea, Andrew M. Coney, Keith L. Brain, Andrew P. Holmes   +6 more
wiley   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

CO2 chemoreflex contributions to ventilatory long‐term facilitation

The Journal of Physiology, EarlyView.
Abstract figure legend To determine whether changes in CO2 chemoreflex sensitivity contribute to ventilatory long‐term facilitation (LTF), we tested the hypothesis that hypercapnic acute intermittent hypoxia (AIH) induces ventilatory LTF and enhances peripheral, but not central, chemoreceptor CO2 chemoreflex sensitivity.
Susan V. Cross, Elizabeth Keen, Tom E. Nightingale, Zubair Ahmed, George M. Balanos, Joseph F. Welch   +5 more
wiley   +1 more source

Microglial Labeling in Mouse Spinal Cord Injury: A Review of Timing, Efficacy, and Specificity

Glia, Volume 74, Issue 12, December 2026.
The transcriptional profile of microglia is significantly altered after spinal cord injury (SCI). When choosing a marker to label microglia after SCI, it is important to consider its specificity for microglia and its stability of expression. ABSTRACT Traumatic spinal cord injury (SCI) is a complex and disabling condition with no curative therapy ...
Ruth Colbert, Julia Di Stefano, Dearbhaile Dooley   +2 more
wiley   +1 more source