Results 211 to 220 of about 29,641 (245)
Annual Review of Immunology, 2001 The adaptive immune response is initiated by the interaction of T cell antigen receptors with major histocompatibility complex molecule-peptide complexes in the nanometer scale gap between a T cell and an antigen-presenting cell, referred to as an immunological synapse.
Andrey Shaw, Mark Davis, Paul Allen
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A check on the immunological synapse
Science Signaling, 2023Blocking Nogo receptor 1 on natural killer cells enhances cell killing by stabilizing contact with target cells.
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Molecular Immunology, 2002
The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
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The immunological synapse plays a central role in organising the immune system. Through their synaptic activity both T and B cells usually, but not always, acquire the information that critically determines the level and nature of the responses that they make. For T cells much of that information comes from epicrine and paracrine cell-cell interactions
R J, Creusot +2 more
openaire +2 more sources
The diversity of immunological synapses
Current Opinion in Immunology, 2003Immunological synapses (ISs) are specialised signalling domains characterised by complex molecular clustering and segregation at the contact site between cells of the immune system. T lymphocytes form different ISs depending on their state of activation and on the antigen-presenting cells with which they interact. The structural features of the various
Alain, Trautmann, Salvatore, Valitutti
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Communication, the centrosome and the immunological synapse [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Recent findings on the behaviour of the centrosome at the immunological synapse suggest a critical role for centrosome polarization in controlling the communication between immune cells required to generate an effective immune response. The features observed at the immunological synapse show parallels to centrosome (basal body) polarization seen in ...
Gillian Griffiths, Jane Stinchcombe
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Plasticity of Immunological Synapses
2009TCR engagement with peptide/MHC complexes displayed on the surface of the antigen-presenting cells is the crucial event in developing an adaptive immune response and occurs within specialized signaling areas named immunological synapses. Immunological synapses are diverse both in structure and function and exhibit a strikingly dynamic molecular ...
Salvatore, Valitutti, Loïc, Dupré
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Signaling and the Immunological Synapse
2010This chapter deals with T cell activation and immunological synapses. It begins with a brief summary of T cell biology to put a discussion of immune synapses into a broader context because the study of immunological synapses addresses issues pertaining mainly to the field of cellular immunology.
Giurisato, Emanuele, Shaw, Andrey S.
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Signaling Amplification at the Immunological Synapse
2009The immunological synapse is a dynamic structure, formed between a T cell and one or more antigen-presenting cells, characterized by lipid and protein segregation, signaling compartmentalization, and bidirectional information exchange through soluble and membrane-bound transmitters.
VIOLA, ANTONELLA +2 more
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[Immunological synapses and neuronal synapses].
Medecine sciences : M/S, 2003The interface between two cells from the immune system has recently been coined "immunological synapse". The authors review recent findings concerning the structure of the synapse formed between T lymphocytes and antigen-presenting cells. T cells can be part of different synapses, depending on the antigen-presenting cell (B cell hybridoma, proteo-lipid
Alain, Trautmann +3 more
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Archivum immunologiae et therapiae experimentalis, 2004
The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity.
Klemmensen, Thomas +2 more
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The induction of a proper adaptive immune response is dependent on the correct transfer of information between antigen-presenting cells (APCs) and antigen-specific T cells. Defects in information transfer may result in the development of diseases, e.g. immunodeficiencies and autoimmunity.
Klemmensen, Thomas +2 more
openaire +1 more source