Results 71 to 80 of about 565,531 (300)

The Role of Immunological Synapse in Predicting the Efficacy of Chimeric Antigen Receptor (CAR) Immunotherapy

Cell Communication and Signaling, 2020
Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation.
Dongfang Liu, S. Badeti, G. Dotti, Jie-gen Jiang, He Wang, J. Dermody, P. Soteropoulos, D. Streck, R. Birge, Chen Liu   +9 more
semanticscholar   +1 more source

Altered actin centripetal retrograde flow in physically restricted immunological synapses.

PLoS ONE, 2010
Antigen recognition by T cells involves large scale spatial reorganization of numerous receptor, adhesion, and costimulatory proteins within the T cell-antigen presenting cell (APC) junction.
Cheng-han Yu, Hung-jen Wu, Yoshihisa Kaizuka, Ronald D Vale, Jay T Groves   +4 more
doaj   +1 more source

Immunological synapse DC-Tcells

, 2017
Immunological synapse DC ...
Leithner, Alexander F ; https://orcid.org/
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

eLife, 2015
Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway for actin filament nucleation. Yet,
Sudha Kumari, David Depoil, Roberta Martinelli, Edward Judokusumo, Guillaume Carmona, Frank B Gertler, Lance C Kam, Christopher V Carman, Janis K Burkhardt, Darrell J Irvine, Michael L Dustin   +10 more
doaj   +1 more source

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Electroencephalographic Normalization as a Biomarker of Clinical Recovery in Down Syndrome Regression Disorder

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Down syndrome regression disorder is a syndrome characterized by subacute loss of cognitive, behavioral, and functional abilities in individuals with Down syndrome. Electroencephalography abnormalities are frequently observed during evaluation, but it remains unclear whether these findings represent a dynamic marker of disease ...
Jonathan D. Santoro, Mackenzie Silverman, Maeve C. Lucas, Mariam M. Yousuf, Samuel T. Otey, Stella V. Gray, Brittany Jordan, Madeline D. Kahan, Latanya D. Agurs, Michelle Van Hirtum Das, Deborah Holder, Devin King, Eileen A. Quinn, Ryan Kammeyer, Michael S. Rafii   +14 more
wiley   +1 more source

A role for TASK2 channels in the human immunological synapse

, 2020
The immunological synapse is a transient junction that occurs when the plasma membrane of a T cell comes in close contact with an APC after recognizing a peptide from the antigen-MHC.
Sauer, Markus, Rolfes, Leoni, Dieterich, Daniela C., Gola, Lukas, Smalla, Dr. Karl-Heinz, Meuth, Sven G., Fernandez-Orth, Juncal, Sukhorukov, Vladimir L., Cerina, Manuela, Kähne, Thilo, Sisario, Dmitri, Andronic, Joseph, Budde, Thomas, Kovac, Stjepana, Bittner, Stefan, Ruck, Tobias   +15 more
core   +1 more source

Masters of manipulation: Viral modulation of the immunological synapse [PDF]

, 2018
In order to thrive, viruses have evolved to manipulate host cell machinery for their own benefit. One major obstacle faced by pathogens is the immunological synapse.
Vincent Piguet, Bayliss, Rebecca J., Piguet, Vincent, Rebecca J. Bayliss   +3 more
core   +1 more source

NKp46 clusters at the immune synapse and regulates NK cell polarization

Frontiers in Immunology, 2015
Natural killer cells play an important role in first-line defense against tumor and virus-infected cells. The activity of NK cells is tightly regulated by a repertoire of cell-surface expressed inhibitory and activating receptors.
Uzi eHadad, Uzi eHadad, Timothy J Thauland, Olivia M Martinez, Manish J Butte, Angel ePorgador, Sheri M Krams   +6 more
doaj   +1 more source