Results 1 to 10 of about 372,410 (315)
SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse
Neuron, 2019 Synapses are fundamental information processing units of the brain and synaptic dysregulation is central to many brain disorders (‘synaptopathies’). However, systematic annotation of synaptic genes and ontology of synaptic processes are currently lacking.
Jan R T Van Weering +2 more
exaly +2 more sources
Cell Biology of Astrocyte-Synapse Interactions
Neuron, 2017 Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses.
Cagla Eroglu, Nicola Allen
exaly +2 more sources
Assessing the individual roles of FII, FV, and FX activity in the thrombin generation process
Frontiers in Cardiovascular Medicine, 2022 Thrombin generation (TG) is known as a physiological approach to assess the hemostatic function. Although it correlates well with thrombosis and bleeding, in the current setup it is not sensitive to the effects of fluctuations in single coagulation ...
Cuicui Bai +8 more
doaj +1 more source
Reference values for thrombin dynamics in platelet rich plasma
Platelets, 2021 Thrombin generation (TG) is a better determinant of the overall function of the hemostatic system than routinely used clotting time-based assays and can be studied more in detail by thrombin dynamics analysis.
Qiuting Yan +3 more
doaj +1 more source
Nature Aging, 2022 Microglia and complement can mediate neurodegeneration in Alzheimer’s disease (AD). By integrative multi-omics analysis, here we show that astrocytic and microglial proteins are increased in TauP301S synapse fractions with age and in a C1q-dependent ...
Borislav Dejanovic +21 more
semanticscholar +1 more source
Neuron, 2013 The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements.
Daniel Choquet, Antoine Triller
openaire +2 more sources
Cell, 2004 The transmission of information across neuronal synapses is an energetically taxing business. Sheng and colleagues monitored the localization of mitochondria following different levels of synaptic activation and discovered that these organelles change their distribution in interesting ways, stalling near synapses when neurons are activated and ...
Schuman, E., Chan, D.
openaire +3 more sources
Research and Practice in Thrombosis and Haemostasis, 2021 Introduction The ST Genesia is a benchtop, fully automated thrombin generation (TG) device. It is completely standardized and ensures a uniform heat distribution throughout the measurement.
Marisa Ninivaggi +3 more
doaj +1 more source
Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay
Frontiers in Cardiovascular Medicine, 2022 BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo +8 more
doaj +1 more source
Patients With Multiple Myeloma Have a Disbalanced Whole Blood Thrombin Generation Profile
Frontiers in Cardiovascular Medicine, 2022 BackgroundMultiple myeloma (MM) is associated with a high prevalence of bleeding and an increased risk of thrombo-embolism. MM patients have reduced platelet- and red blood cell (RBC) numbers in blood, which may indicate that the paradoxical hemostasis ...
Li Li +15 more
doaj +1 more source