Results 11 to 20 of about 372,410 (315)
Bioinspired mechano-photonic artificial synapse based on graphene/MoS2 heterostructure
Science Advances, 2021 A bioinspired mechano-photonic artificial synapse with synergistic mechanical and optical plasticity is demonstrated. Developing multifunctional and diversified artificial neural systems to integrate multimodal plasticity, memory, and supervised learning
Jinran Yu +9 more
semanticscholar +1 more source
Combining human platelet proteomes and transcriptomes: possibilities and challenges
Platelets, 2023 The anucleate human platelets contain a broad pattern of mRNAs and other RNA transcripts. The high quantitative similarity of mRNAs in megakaryocytes and platelets from different sources points to a common origin, and suggests a random redistribution of ...
Jingnan Huang +2 more
doaj +1 more source
The Journal of Neuroscience, 1996 The strength of many synapses is modified by various use and time-dependent processes, including facilitation and depression. A general description of synaptic transfer characteristics must account for the history-dependence of synaptic efficacy and should be able to predict the postsynaptic response to any temporal pattern of presynaptic activity.
K, Sen +3 more
openaire +2 more sources
Synapse pathology in Alzheimer's disease.
Seminars in Cell and Developmental Biology, 2022 Synapse loss and damage are central features of Alzheimer's disease (AD) and contribute to the onset and progression of its behavioural and physiological features.
Jessica Griffiths, S. Grant
semanticscholar +1 more source
Stroke subtype-dependent synapse elimination by reactive gliosis in mice
Nature Communications, 2021 The pathological role of reactive gliosis in CNS repair remains controversial. In this study, using murine ischemic and hemorrhagic stroke models, we demonstrated that microglia/macrophages and astrocytes are differentially involved in engulfing synapses
Xiaojing Shi +14 more
semanticscholar +1 more source
Electrochemistry at the Synapse [PDF]
Annual Review of Analytical Chemistry, 2019 Electrochemical measurements of neurotransmitters provide insight into the dynamics of neurotransmission. In this review, we describe the development of electrochemical measurements of neurotransmitters and how they started with extrasynaptic measurements but now are pushing toward synaptic measurements.
Mimi, Shin +3 more
openaire +2 more sources
Complement and Microglia Mediate Early Synapse Loss in Alzheimer Mouse Models
Science, 2016 Too much cleaning up The complement system and microglia seek out and destroy unwanted cellular debris for the peripheral immune system as well as excess synapses in the developing brain. Hong et al. now show how the system may go haywire in adults early
Soyon Hong +12 more
semanticscholar +1 more source
Microglial Remodeling of the Extracellular Matrix Promotes Synapse Plasticity
Cell, 2020 SUMMARY Synapse remodeling is essential to encode experiences into neuronal circuits. Here, we define a molecular interaction between neurons and microglia that drives experience-dependent synapse remodeling in the hippocampus.
P. Nguyen +10 more
semanticscholar +1 more source
mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists
Science, 2010 Antidepressant Action of Ketamine In contrast to the weeks or months of treatment required for standard antidepressant medication, ketamine administration produces an antidepressant response within 4 to 6 hours in depressed patients. What lies behind the
Nanxin Li +8 more
semanticscholar +1 more source
Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease.
Journal of Clinical Investigation, 2020 Type I interferon (IFN) is a key cytokine that curbs viral infection and cell malignancy. Previously, we have demonstrated a potent IFN immunogenicity of nucleic acid (NA)-containing amyloid fibrils in the periphery.
Ethan R. Roy +15 more
semanticscholar +1 more source