Results 31 to 40 of about 279,988 (315)

Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

eLife, 2021
Developing neurons form synapses at a high rate. Synaptic transmission is very energy-demanding and likely requires ATP production by mitochondria nearby.
Catia AP Silva, Annik Yalnizyan-Carson, M Victoria Fernández Busch, Mike van Zwieten, Matthijs Verhage, Christian Lohmann   +5 more
doaj   +1 more source

Treatments for intracranial hypertension in acute brain-injured patients: grading, timing, and association with outcome. Data from the SYNAPSE-ICU study

, 2023
Purpose: Uncertainties remain about the safety and efficacy of therapies for managing intracranial hypertension in acute brain injured (ABI) patients.
Rebora, Paola, Guglielmi, Angelo, Graziano, Francesca, Robba, Chiara, Galimberti, Stefania, SYNAPSE-ICU Investigators, Citerio, Giuseppe, Taccone, Fabio S, Cotoia, Antonella   +8 more
core   +1 more source

Interaction proteomics of synapse protein complexes [PDF]

, 2010
The brain integrates complex types of information, and executes a wide range of physiological and behavioral processes. Trillions of tiny organelles, the synapses, are central to neuronal communication and information processing in the brain.
Patricia Klemmer, Klemmer, P., Smit, A.B., Ka Wan Li, August B. Smit, Li, K.W., Li, K.W.; id_orcid   +6 more
core   +1 more source

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

TH Open
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation.
Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa   +8 more
doaj   +1 more source

Thrombomodulin is a stronger indicator of combined oral contraceptives-induced activated protein C pathway resistance in the thrombin generation test than activated protein C

Frontiers in Cardiovascular Medicine
BackgroundThe mechanism by which combined oral contraceptives (COCs) lead to hypercoagulation is not fully understood, although activated protein C (APC) pathway resistance has been implicated.
Marisa Ninivaggi, Lily Sokolova, Lily Sokolova, Demy Donkervoort, Bas de Laat, Bas de Laat, Romy de Laat-Kremers   +6 more
doaj   +1 more source

Correction to: Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1

BMC Cancer, 2019
Following publication of the original article [1], the authors have re-evaluated the authorship for this article. The updated author group is:
Ho-Keun Kwon, Ji-Sun Hwang, Jae-Seon So, Choong-Gu Lee, Anupama Sahoo, Jae-Ha Ryu, Won Kyung Jeon, Byoung Seob Ko, Sung Haeng Lee, Zee Yong Park, Sin-Hyeog Im   +10 more
doaj   +1 more source

Coagulation parameters predict COVID-19-related thrombosis in a neural network with a positive predictive value of 98%

Frontiers in Immunology, 2022
Thrombosis is a major clinical complication of COVID-19 infection. COVID-19 patients show changes in coagulation factors that indicate an important role for the coagulation system in the pathogenesis of COVID-19.
Romy de Laat-Kremers, Raf De Jongh, Raf De Jongh, Marisa Ninivaggi, Aernoud Fiolet, Rob Fijnheer, Jasper Remijn, Bas de Laat, Bas de Laat   +8 more
doaj   +1 more source

From biomaterial-based data storage to bio-inspired artificial synapse [PDF]

, 2018
The implementation of biocompatible and biodegradable information storage would be a significant step toward next-generation green electronics. On the other hand, benefiting from high density, multifunction, low power consumption and multilevel data ...
Su-Ting Han, Lv, Ziyu, Han, Su-Ting, Roy, V.A.L., Ziyu Lv, Zhou, Ye, V.A.L. Roy, Ye Zhou   +7 more
core   +1 more source

The Innovative Medicines Initiative neurodegeneration portfolio: From individual projects to collaborative networks

Frontiers in Neurology, 2022
The IMI public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA) was launched in 2008 with an initial budget of €2 billion.
Diana O'Rourke, Nina Coll-Padrós, Angela Bradshaw, Lewis Killin, Laurent Pradier, Jean Georges, Dalia M. Dawoud, Dalia M. Dawoud, Lennert Steukers, Carlos Diaz   +9 more
doaj   +1 more source

Automated Imaging and Analysis of Platelet, Coagulation and Fibrinolysis Activities Using a Novel Flow Chip-Based System at Physiological Temperature

Micromachines
Conventional whole-blood flow assays for quantifying thrombus formation are typically performed at room temperature and are technically demanding, which limits their translational applicability.
Xiang Gui, Bibian M. E. Tullemans, Bas de Laat, Johan W. M. Heemskerk, Frauke Swieringa   +4 more
doaj   +1 more source