Results 31 to 40 of about 372,410 (315)

Microglia promote learning-dependent synapse formation through BDNF

Cell, 2013
SUMMARY Microglia are the resident macrophages of the central nervous system and their functions have been extensively studied in various brain pathologies.
Christopher N. Parkhurst, Guang Yang, I. Ninan, J. Savas, J. Yates, J. Lafaille, B. Hempstead, D. Littman, W. Gan   +8 more
semanticscholar   +1 more source

Autophagy controls the induction and developmental decline of NMDAR-LTD through endocytic recycling

Nature Communications, 2020
NMDA receptor-dependent long-term depression (NMDAR-LTD) is a form of synaptic plasticity mediated by reduced recycling of AMPA receptors to the plasma membrane.
Hongmei Shen, Huiwen Zhu, Debabrata Panja, Qinhua Gu, Zheng Li   +4 more
doaj   +1 more source

The Value of Brain Imaging and Electrophysiological Testing for Early Screening of Autism Spectrum Disorder: A Systematic Review

Frontiers in Neuroscience, 2022
Given the significance of validating reliable tests for the early detection of autism spectrum disorder (ASD), this systematic review aims to summarize available evidence of neuroimaging and neurophysiological changes in high-risk infants to improve ASD ...
Cullen Clairmont, Jiuju Wang, Jiuju Wang, Samia Tariq, Hannah Tayla Sherman, Mingxuan Zhao, Xue-Jun Kong, Xue-Jun Kong   +7 more
doaj   +1 more source

Feed-forward recruitment of electrical synapses enhances synchronous spiking in the mouse cerebellar cortex

eLife, 2020
In the cerebellar cortex, molecular layer interneurons use chemical and electrical synapses to form subnetworks that fine-tune the spiking output of the cerebellum.
Andreas Hoehne, Maureen H McFadden, David A DiGregorio   +2 more
doaj   +1 more source

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α

Nature Communications, 2017
Molecular mechanisms regulating the development of inhibitory synapses are poorly understood. Here the authors show that IgSF21 interacts with neurexin2α to induce presynaptic differentiation of inhibitory synapses, and that mice lacking IgSF21 exhibit ...
Yuko Tanabe, Yusuke Naito, Cristina Vasuta, Alfred Kihoon Lee, Youssouf Soumounou, Michael W. Linhoff, Hideto Takahashi   +6 more
doaj   +1 more source

Activity-dependent regulation of mitochondrial motility in developing cortical dendrites

eLife, 2021
Developing neurons form synapses at a high rate. Synaptic transmission is very energy-demanding and likely requires ATP production by mitochondria nearby.
Catia AP Silva, Annik Yalnizyan-Carson, M Victoria Fernández Busch, Mike van Zwieten, Matthijs Verhage, Christian Lohmann   +5 more
doaj   +1 more source

The clinical promise of biomarkers of synapse damage or loss in Alzheimer’s disease

Alzheimer's Research & Therapy, 2020
Synapse damage and loss are fundamental to the pathophysiology of Alzheimer’s disease (AD) and lead to reduced cognitive function. The goal of this review is to address the challenges of forging new clinical development approaches for AD therapeutics ...
M. Colom‐Cadena, T. Spires‐Jones, H. Zetterberg, K. Blennow, Anthony O. Caggiano, S. DeKosky, Howard M. Fillit, John E. Harrison, Lon S. Schneider, P. Scheltens, W. de Haan, M. Grundman, C. V. van Dyck, Nicholas J. Izzo, Susan M. Catalano   +14 more
semanticscholar   +1 more source

Increased synapse elimination by microglia in schizophrenia patient-derived models of synaptic pruning

Nature Neuroscience, 2019
Synapse density is reduced in postmortem cortical tissue from schizophrenia patients, which is suggestive of increased synapse elimination. Using a reprogrammed in vitro model of microglia-mediated synapse engulfment, we demonstrate increased synapse ...
C. Sellgren, Jessica Gracias, Bradley Watmuff, J. Biag, Jessica M. Thanos, Paul B. Whittredge, Ting Fu, Kathleen A. Worringer, Hannah E. Brown, Jennifer Wang, A. Kaykas, R. Karmacharya, Carleton P. Goold, S. Sheridan, R. Perlis   +14 more
semanticscholar   +1 more source

Plasmin generation kinetics reveal a hyperfibrinolytic phenotype in patients with pancreatic ductal adenocarcinoma

TH Open
Background Thromboembolic complications are common in patients with pancreatic cancer, with up to 20% of patients developing venous thromboembolism (VTE).
Ruth A.L. Willems, Ilaria De Simone, Samia Tufaha, Joke Konings, Harmen Middelveld, Nicol Pepels-Aarts, Hugo ten Cate, Bas de Laat, Mark Roest, Dana Huskens, Judith de Vos-Geelen   +10 more
doaj   +1 more source

Thrombin generation in low plasma volumes

Thrombosis Journal, 2018
Accurate thrombin generation determination by calibrated automated thrombinography can be sustained when reducing the plasma and reagent volumes up to half, but not for higher reductions or plasma dilutions.
Saartje Bloemen, Hilde Kelchtermans, H. Coenraad Hemker   +2 more
doaj   +1 more source