Results 1 to 10 of about 49,195 (253)

Platelets and Thrombin Generation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin.
Maureane Hoffman, Dougald Monroe, Harold R Roberts   +2 more
exaly   +3 more sources

The measurement and application of thrombin generation [PDF]

British Journal of Haematology, 2005
SummaryIt is the capacity to generate thrombin, and the enzymatic work that thrombin does, that determines blood coagulability. Therefore, measurement of the enzymatic work potential of thrombin provides a method for quantifying the composite effect of the multiple factors that determine coagulation capacity.
Trevor Baglin
exaly   +3 more sources

Recollections on thrombin generation [PDF]

Journal of Thrombosis and Haemostasis, 2008
Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.
exaly   +3 more sources

Thrombin generation, a function test of the haemostaticthrombotic system [PDF]

Thrombosis and Haemostasis, 2006
SummaryBy the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (< 5%). Evidence is growing that the
Suzette Beguin, Raed Al Dieri, H Coenraad Hemker   +2 more
exaly   +4 more sources

Inhibition of Intrinsic Thrombin Generation

Drug Target Insights, 2006
Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief
doaj   +4 more sources

Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy

Frontiers in Cardiovascular Medicine, 2021
Background: Patients using dual antiplatelet therapy after percutaneous coronary intervention are at risk for bleeding. It is currently unknown whether thrombin generation can be used to identify patients receiving dual antiplatelet therapy with ...
C. P. D. M. de Breet, C. P. D. M. de Breet, S. Zwaveling, S. Zwaveling, M. J. A. Vries, R. G. van Oerle, Y. M. C. Henskens, A. W. J. van't Hof, A. W. J. van't Hof, P. E. J. van der Meijden, L. Veenstra, H. ten Cate, H. ten Cate, R. H. Olie, R. H. Olie   +14 more
doaj   +1 more source

Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma

Scientific Reports, 2023
Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo, Claus V. B. Hviid, Ole Brink, Svend Juul, Lars C. Borris, Anne-Mette Hvas   +5 more
doaj   +1 more source

Editorial: Advances in thrombin generation

Frontiers in Cardiovascular Medicine, 2023
Romy de Laat-Kremers, Stéphane Zuily, Bas de Laat, Bas de Laat   +3 more
doaj   +3 more sources

From principle to practice: bridging the gap in patient profiling. [PDF]

PLoS ONE, 2013
The standard clinical coagulation assays, activated partial thromboplastin time (aPTT) and prothrombin time (PT) cannot predict thrombotic or bleeding risk.
Jonathan H Foley, Thomas Orfeo, Anetta Undas, Kelley C McLean, Ira M Bernstein, Georges-Etienne Rivard, Kenneth G Mann, Stephen J Everse, Kathleen E Brummel-Ziedins   +8 more
doaj   +1 more source

Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project. [PDF]

PLoS ONE, 2016
BACKGROUND:Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify ...
Laura Martin-Fernandez, Andrey Ziyatdinov, Marina Carrasco, Juan Antonio Millon, Angel Martinez-Perez, Noelia Vilalta, Helena Brunel, Montserrat Font, Anders Hamsten, Juan Carlos Souto, José Manuel Soria   +10 more
doaj   +1 more source