Results 1 to 10 of about 3,891,002 (203)
Thrombin Generation in Acute and Chronic Liver Disease in Children [PDF]
DiagnosticsBackground: Pediatric liver disease is frequently associated with abnormal conventional coagulation tests; however, prothrombin time expressed as international normalized ratio (PT-INR) incompletely reflect global hemostatic balance.
Giovina Di Felice +11 more
doaj +2 more sources
Haematologica, 2019 Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseases. This study aims to explore the relation between thrombin generation and cardiovascular risk factors, cardiovascular diseases, and total mortality ...
Pauline C.S. van Paridon +15 more
doaj +2 more sources
Thrombin Generation and Cirrhosis: State of the Art and Perspectives [PDF]
Seminars in Thrombosis and Hemostasis, 2020 Epidemiological and laboratory studies performed in the last decades have changed our understanding of coagulopathy in cirrhosis, from a condition at increased risk of hemorrhagic events to one at higher thrombotic risk.
A. Lebreton +5 more
semanticscholar +6 more sources
Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project. [PDF]
PLoS ONE, 2016 BACKGROUND:Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify ...
Laura Martin-Fernandez +10 more
doaj +2 more sources
Platelets and Thrombin Generation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2002 This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin.
Dougald M Monroe +2 more
exaly +3 more sources
Recurrent venous thromboembolism: association with thrombin generation and d-dimer [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: In patients with a first event of venous thromboembolism (VTE) clinicians must decide when to stop anticoagulation, evaluating the risk of recurrent thrombosis.
Eugenia Biguzzi +4 more
doaj +2 more sources
Thrombin Generation and Cancer: Contributors and Consequences
Cancers, 2019 The high occurrence of cancer-associated thrombosis is associated with elevated thrombin generation. Tumour cells increase the potential for thrombin generation both directly, through the expression and release of procoagulant factors, and indirectly ...
Caroline J Reddel +2 more
exaly +2 more sources
Recollections on thrombin generation [PDF]
Journal of Thrombosis and Haemostasis, 2008 Against an autobiographic background, a historical sketch is given of the development of the technique of thrombin generation, from subsampling to duly calibrated continuous measurement with fluorogenic substrates. Its application to various problems in the pathophysiology of hemostasis and thrombosis is discussed.
H C Hemker
exaly +3 more sources
The measurement and application of thrombin generation [PDF]
British Journal of Haematology, 2005 SummaryIt is the capacity to generate thrombin, and the enzymatic work that thrombin does, that determines blood coagulability. Therefore, measurement of the enzymatic work potential of thrombin provides a method for quantifying the composite effect of the multiple factors that determine coagulation capacity.
Trevor Baglin
exaly +3 more sources
Thrombin Generation in Zebrafish Blood. [PDF]
PLoS ONE, 2016 To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential.
Evelien Schurgers +5 more
doaj +5 more sources