Results 1 to 10 of about 2,633,554 (103)

Thrombin Generation in Acute Ischaemic Stroke [PDF]

Stroke Research and Treatment, 2016
Introduction. Stroke remains a global leading cause of death and disability. Traditional description of plasma biology in the aftermath of acute ischaemic stroke favours development of hypercoagulability, resulting from complex interplay between plasma ...
Ibrahim O. Balogun, Lara N. Roberts, Raj Patel, Rohan Pathansali, Lalit Kalra, Roopen Arya   +5 more
doaj   +2 more sources

Thrombin-generating capacity in patients with von Willebrand’s disease

Haematologica, 2007
Background and Objectives on Willebrand’s disease (VWD) is the most common hereditary bleeding disorder. Its severity can be classified on the basis of von Willebrand factor (VWF) and factor VIII (FVIII) plasma levels and according to the clinical ...
Lucia Rugeri, Suzette Beguin, Coenraad Hemker, Jean-Claude Bordet, Raphael Fleury, Brigitte Chatard, Claude Negrier, Yesim Dargaud   +7 more
doaj   +1 more source

Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood

Research and Practice in Thrombosis and Haemostasis
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Michael T. Stobb, Keith B. Neeves, Dougald M. Monroe, Suzanne S. Sindi, Karin Leiderman, Aaron L. Fogelson   +5 more
doaj   +1 more source

Exploring the utility of a novel point‐of‐care whole blood thrombin generation assay following trauma: A pilot study

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction Plasma thrombin generation kinetics as measured by the calibrated automated thrombogram (CAT) assay is a predictor of symptomatic venous thromboembolism after trauma.
Michael J. Ferrara, Taleen A. MacArthur, Saulius Butenas, Kenneth G. Mann, Joseph M. Immermann, Grant M. Spears, Kent R. Bailey, Rosemary A. Kozar, Stephanie F. Heller, Erica A. Loomis, Daniel Stephens, Myung S. Park   +11 more
doaj   +1 more source

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and ...
Rahul Kumar, Vijay K. Sonkar, Jagadish Swamy, Azaj Ahmed, Anjali A. Sharathkumar, Gary L. Pierce, Sanjana Dayal   +6 more
doaj   +1 more source

Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation. [PDF]

PLoS ONE, 2012
Factor (f)Xa is a critical enzyme in blood coagulation that is responsible for the initiation and propagation of thrombin generation. Previously we have shown that analysis of computationally generated thrombin profiles is a tool to investigate ...
Kathleen E Brummel-Ziedins, Thomas Orfeo, Matthew Gissel, Kenneth G Mann, Frits R Rosendaal   +4 more
doaj   +1 more source

Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study

Research and Practice in Thrombosis and Haemostasis
Background: The thrombin dynamics method has been used as an add-on analysis method for the thrombin generation test over the past years to study the balance between pro- and anticoagulant pathways.
Amalia De Curtis, Romy de Laat-Kremers, Simona Costanzo, Augusto Di Castelnuovo, Marisa Ninivaggi, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni   +51 more
doaj   +1 more source

Thrombin Generation in Acute and Chronic Liver Disease in Children

Diagnostics
Background: Pediatric liver disease is frequently associated with abnormal conventional coagulation tests; however, prothrombin time expressed as international normalized ratio (PT-INR) incompletely reflect global hemostatic balance.
Giovina Di Felice, Anna Lisa Montemari, Andrea Pietrobattista, Luca Della Volpe, Antonella Mosca, Daniela Liccardo, Simona Pezzi, Chiara Giorni, Matteo Luciani, Danilo Alunni Fegatelli, Annarita Vestri, Ottavia Porzio   +11 more
doaj   +1 more source

Abacavir use is associated with increased prothrombin conversion

Frontiers in Immunology, 2023
There is ongoing debate as to whether abacavir (ABC) increases the risk for cardiovascular disease(CVD) in people living with HIV (PLHIV) and the mechanisms underlying this possible association.
Qiuting Yan, Qiuting Yan, Shengshi Huang, Shengshi Huang, Wouter van der Heijden, Marisa Ninivaggi, Lisa van de Wijer, Romy de Laat-Kremers, Andre J. Van der Ven, Bas de Laat, Bas de Laat, Quirijn de Mast   +11 more
doaj   +1 more source

Antiplatelet agents can promote two-peaked thrombin generation in platelet rich plasma: mechanism and possible applications. [PDF]

PLoS ONE, 2013
BACKGROUND: Thrombin generation assay is a convenient and widely used method for analysis of the blood coagulation system status. Thrombin generation curve (TGC) is usually bell-shaped with a single peak, but there are exceptions.
Ivan D Tarandovskiy, Elena O Artemenko, Mikhail A Panteleev, Elena I Sinauridze, Fazoil I Ataullakhanov   +4 more
doaj   +1 more source