Results 31 to 40 of about 49,195 (253)

Thrombin generation and bleeding in haemophilia A [PDF]

Haemophilia, 2009
Summary.  Haemophilia A displays phenotypic heterogeneity with respect to clinical severity. The aim of this study was to determine if tissue factor (TF)‐initiated thrombin generation profiles in whole blood in the presence of corn trypsin inhibitor (CTI) are predictive of bleeding risk in haemophilia A. We studied factor(F) VIII deficient individuals (
K E, Brummel-Ziedins, M F, Whelihan, M, Gissel, K G, Mann, G E, Rivard   +4 more
openaire   +2 more sources

Effects of platelets activated by different agonists on fibrin formation and thrombin generation

Platelets, 2023
Activated platelets possess procoagulant activity expressing on their surface phosphatidylserine (PS), a substrate for assembling coagulation complexes. We examined the effects of platelets activated by different agonists on fibrin formation and thrombin
Ivan A. Muravlev, Anatoly B. Dobrovolsky, Olga A. Antonova, Svetlana G. Khaspekova, Alexey V. Mazurov   +4 more
doaj   +1 more source

Thrombin Generation and Cirrhosis: State of the Art and Perspectives [PDF]

Seminars in Thrombosis and Hemostasis, 2020
AbstractEpidemiological and laboratory studies performed in the last decades have changed our understanding of coagulopathy in cirrhosis, from a condition at increased risk of hemorrhagic events to one at higher thrombotic risk. However, it is not clear whether the decrease in factors that promote (except factor [F] VIII) versus inhibit coagulation in ...
Lebreton, Aurélien, Sinegre, Thomas, Lecompte, Thomas, Talon, Laurie, Abergel, Armand, Lisman, Ton   +5 more
openaire   +5 more sources

Thrombin generation in a woman with heterozygous factor V Leiden and combined oral contraceptives: A case report

Research and Practice in Thrombosis and Haemostasis, 2020
Combined oral contraceptives and factor V Leiden mutation are multiplicative risk factors for venous thromboembolism. However, it remains unknown whether this multiplicative effect is reflected in thrombin generation assays.
Maxime G. Zermatten, Debora Bertaggia Calderara, Alessandro Aliotta, Lorenzo Alberio   +3 more
doaj   +1 more source

Thrombin-generating capacity in patients with von Willebrand’s disease

Haematologica, 2007
Background and Objectives on Willebrand’s disease (VWD) is the most common hereditary bleeding disorder. Its severity can be classified on the basis of von Willebrand factor (VWF) and factor VIII (FVIII) plasma levels and according to the clinical ...
Lucia Rugeri, Suzette Beguin, Coenraad Hemker, Jean-Claude Bordet, Raphael Fleury, Brigitte Chatard, Claude Negrier, Yesim Dargaud   +7 more
doaj   +1 more source

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and ...
Rahul Kumar, Vijay K. Sonkar, Jagadish Swamy, Azaj Ahmed, Anjali A. Sharathkumar, Gary L. Pierce, Sanjana Dayal   +6 more
doaj   +1 more source

Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood

Research and Practice in Thrombosis and Haemostasis
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Michael T. Stobb, Keith B. Neeves, Dougald M. Monroe, Suzanne S. Sindi, Karin Leiderman, Aaron L. Fogelson   +5 more
doaj   +1 more source

Exploring the utility of a novel point‐of‐care whole blood thrombin generation assay following trauma: A pilot study

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction Plasma thrombin generation kinetics as measured by the calibrated automated thrombogram (CAT) assay is a predictor of symptomatic venous thromboembolism after trauma.
Michael J. Ferrara, Taleen A. MacArthur, Saulius Butenas, Kenneth G. Mann, Joseph M. Immermann, Grant M. Spears, Kent R. Bailey, Rosemary A. Kozar, Stephanie F. Heller, Erica A. Loomis, Daniel Stephens, Myung S. Park   +11 more
doaj   +1 more source

Analysis of thrombin generation in plasma [PDF]

Computers in Biology and Medicine, 1994
Thrombin is the central enzyme of haemostasis. Information on the production and inhibition of thrombin in plasma is important for evaluating the state of the coagulation system. Measurement of thrombin generation in plasma using small oligopeptide chromogenic substrates gives rise to a signal that not only reflects the enzymatic activity of free ...
Kessels, Han, Willems, George, Hemker, H. Coenraad   +2 more
openaire   +3 more sources

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source