Results 31 to 40 of about 97,937 (350)

Thrombin generation assays: accruing clinical relevance [PDF]

Current Opinion in Hematology, 2004
After decades of near oblivion, thrombin generation is being revived as an overall function test of the plasmatic coagulation system in platelet-poor plasma (PPP). In platelet-rich plasma (PRP) it assesses platelet procoagulant functions as well.The recently developed use of special fluorogenic thrombin substrates allows monitoring of thrombin ...
Hemker, H. Coenraad, Al Dieri, Raed, Beguin, Suzette   +2 more
openaire   +3 more sources

Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma

Clinical and Applied Thrombosis/Hemostasis, 2020
We investigated the relationships between circulating procoagulants and trauma severity, including cellular destruction, and the effects of thrombin generation on procoagulants in a rat blunt trauma model. The rats were subjected to tumbling blunt trauma,
Mineji Hayakwa MD, PhD, Takayoshi Ooyasu MD, Yoshihiro Sadamoto MD, Tomoyo Saito MD, PhD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD, Masahiro Ieko MD, PhD   +8 more
doaj   +1 more source

In vitro reversal of direct factor Xa inhibitors: Direct comparison of andexanet alfa and prothrombin complex concentrates Cofact and Beriplex/Kcentra

Research and Practice in Thrombosis and Haemostasis, 2022
Background Both andexanet alfa and four‐factor prothrombin complex concentrate (4F‐PCC) are clinically applied reversal agents for direct factor Xa inhibitors (FXaIs) in emergency situations. Controversy exists whether 4F‐PCC is as effective as andexanet
Herm Jan M. Brinkman, Marleen Zuurveld, Joost C. M. Meijers   +2 more
doaj   +1 more source

Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting

Cardiovascular Diabetology, 2018
Background As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis.
Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer, Thomas Gremmel   +4 more
doaj   +1 more source

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis. [PDF]

PLoS ONE, 2016
Circulating microparticles (MPs) derived from endothelial cells and blood cells bear procoagulant activity and promote thrombin generation. Thrombin exerts proinflammatory effects mediating the progression of atherosclerosis.
Patrick Horn, Gülsüm Erkilet, Verena Veulemans, Patric Kröpil, Leon Schurgers, Tobias Zeus, Christian Heiss, Malte Kelm, Ralf Westenfeld   +8 more
doaj   +1 more source

Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester [PDF]

, 2017
Background: Pregnancy is a hypercoagulable state associated with an increased risk of venous thrombosis, which begins during the first trimester, but the exact time of onset is unknown.
Bagot, C.N., Freeman, D.J., Jordan, F., Leishman, E., Onyiaodike, C.C.   +4 more
core   +1 more source

Platelet Biochemistry and Morphology after Cryopreservation [PDF]

, 2020
Platelet cryopreservation has been investigated for several decades as an alternative to room temperature storage of platelet concentrates. The use of dimethylsulfoxide as a cryoprotectant has improved platelet storage and cryopreserved concentrates can ...
Compernolle, Veerle, Feys, Hendrik, Six, Katrijn   +2 more
core   +1 more source

Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity. [PDF]

PLoS ONE, 2011
Pre-eclampsia is a complication of pregnancy associated with activation of coagulation. It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could
Chris Gardiner, Dionne S Tannetta, Carol A Simms, Paul Harrison, Christopher W G Redman, Ian L Sargent   +5 more
doaj   +1 more source

Trombingenerációs vizsgálatok és klinikai alkalmazásuk [PDF]

, 2014
Thrombin is a key enzyme of the coagulation system, having both pro- And anticoagulant functions. Thus, the generation of thrombin is one of the most important steps in coagulation.
Kern A, Várnai, Katalin, Vásárhelyi, Barna   +2 more
core   +1 more source

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +1 more source