Results 31 to 40 of about 3,896,793 (331)

Thrombin generation in the Glasgow Myocardial Infarction Study. [PDF]

PLoS ONE, 2013
BACKGROUND: Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to myocardial infarction (MI) we explored thrombin generation analysis in plasma from ...
Machiel Smid, Arne W J H Dielis, Henri M H Spronk, Ann Rumley, Rene van Oerle, Mark Woodward, Hugo ten Cate, Gordon Lowe   +7 more
doaj   +1 more source

Hypofibrinolytic state and high thrombin generation may play a major role in SARS‐COV2 associated thrombosis

Journal of Thrombosis and Haemostasis, 2020
Thirty percent of Covid‐19 patients admitted to intensive care units present with thrombotic complications despite thromboprophylaxis. Bed rest, obesity, hypoxia, coagulopathy, and acute excessive inflammation are potential mechanisms reported by ...
C. Nougier, R. Benoit, M. Simon, H. Desmurs‐Clavel, G. Marcotte, L. Argaud, J. David, A. Bonnet, C. Négrier, Y. Dargaud   +9 more
semanticscholar   +1 more source

Evaluation of the hemostatic potential at coronary artery bypass surgery during long-term aspirin therapy [PDF]

Терапевтический архив, 2016
Aim. To estimate thrombin generation test parameters in patients with coronary heart disease during coronary artery bypass surgery under extracorporeal circulation after transfusion of donor platelet concentrates during long-term therapy with ...
O V Gruzdeva, E V Fanaskova, O E Akbasheva, E G Uchasova, T Yu Penskaya, G P Plotnikov, Yu A Dyleva, K E Krivoshapova, O L Barbarash   +8 more
doaj   +1 more source

Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma

Clinical and Applied Thrombosis/Hemostasis, 2020
We investigated the relationships between circulating procoagulants and trauma severity, including cellular destruction, and the effects of thrombin generation on procoagulants in a rat blunt trauma model. The rats were subjected to tumbling blunt trauma,
Mineji Hayakwa MD, PhD, Takayoshi Ooyasu MD, Yoshihiro Sadamoto MD, Tomoyo Saito MD, PhD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD, Masahiro Ieko MD, PhD   +8 more
doaj   +1 more source

Defining the boundaries of normal thrombin generation: investigations into hemostasis. [PDF]

PLoS ONE, 2012
In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently healthy individuals. The significance of this variability remains obscure, in part because it is the backdrop against which the hemostatic consequences of
Christopher M Danforth, Thomas Orfeo, Stephen J Everse, Kenneth G Mann, Kathleen E Brummel-Ziedins   +4 more
doaj   +1 more source

Covid-19-Associated Coagulopathy: Biomarkers of Thrombin Generation and Fibrinolysis Leading the Outcome

Journal of Clinical Medicine, 2020
Background: Coronavirus Disease 2019 (COVID-19)-associated coagulopathy is characterized by a prothrombotic state not yet comprehensively studied. We investigated the coagulation pattern of patients with COVID-19 acute respiratory distress syndrome (ARDS)
M. Ranucci, C. Sitzia, E. Baryshnikova, Umberto Di Dedda, R. Cardani, F. Martelli, M. C. Corsi Romanelli   +6 more
semanticscholar   +1 more source

Thrombin generation in vascular tissue [PDF]

Journal of Thrombosis and Haemostasis, 2006
Classically, it is thought that the vast majority of thrombin is generated on the surface of platelets, however, thrombotic events occur in patients despite treatment with potent antiplatelet agents.In freshly harvested left internal mammary artery (IMA) sections, addition of CaCl2 and platelet-poor plasma (PPP) were sufficient to stimulate a profound ...
A, Pathak, R, Zhao, D M, Monroe, H R, Roberts, B C, Sheridan, C H, Selzman, G A, Stouffer   +6 more
openaire   +2 more sources

Extracellular Vesicles Derived From Platelets, Red Blood Cells, and Monocyte-Like Cells Differ Regarding Their Ability to Induce Factor XII-Dependent Thrombin Generation

Frontiers in Cell and Developmental Biology, 2020
As transmitters of biological information, extracellular vesicles (EVs) are crucial for the maintenance of physiological homeostasis, but also contribute to pathological conditions, such as thrombotic disorders.
C. Tripisciano, R. Weiss, Sobha Karuthedom George, M. Fischer, V. Weber   +4 more
semanticscholar   +1 more source

Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting

Cardiovascular Diabetology, 2018
Background As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis.
Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer, Thomas Gremmel   +4 more
doaj   +1 more source

In vitro reversal of direct factor Xa inhibitors: Direct comparison of andexanet alfa and prothrombin complex concentrates Cofact and Beriplex/Kcentra

Research and Practice in Thrombosis and Haemostasis, 2022
Background Both andexanet alfa and four‐factor prothrombin complex concentrate (4F‐PCC) are clinically applied reversal agents for direct factor Xa inhibitors (FXaIs) in emergency situations. Controversy exists whether 4F‐PCC is as effective as andexanet
Herm Jan M. Brinkman, Marleen Zuurveld, Joost C. M. Meijers   +2 more
doaj   +1 more source