Results 11 to 20 of about 97,937 (350)

Thrombin Generation in Zebrafish Blood. [PDF]

PLoS ONE, 2016
To better understand hypercoagulability as an underlying cause for thrombosis, the leading cause of death in the Western world, new assays to study ex vivo coagulation are essential.
Evelien Schurgers, Martijn Moorlag, Coenraad Hemker, Theo Lindhout, Hilde Kelchtermans, Bas de Laat   +5 more
doaj   +6 more sources

Platelets and Thrombin Generation [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2002
This review examines the evidence that platelets play a major role in localizing and controlling the burst of thrombin generation leading to fibrin clot formation. From the first functional description of platelets, it has been recognized that platelets supply factors that support the activation of prothrombin.
Dougald M, Monroe, Maureane, Hoffman, Harold R, Roberts   +2 more
openaire   +4 more sources

Editorial: Advances in thrombin generation [PDF]

Frontiers in Cardiovascular Medicine, 2023
Romy de Laat-Kremers, Stéphane Zuily, Bas de Laat, Bas de Laat   +3 more
doaj   +4 more sources

Recurrent venous thromboembolism: association with thrombin generation and d-dimer [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: In patients with a first event of venous thromboembolism (VTE) clinicians must decide when to stop anticoagulation, evaluating the risk of recurrent thrombosis.
Eugenia Biguzzi, Kristien Winckers, Tilman M. Hackeng, Frits R. Rosendaal, Astrid van Hylckama Vlieg   +4 more
doaj   +2 more sources

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and ...
Rahul Kumar, Vijay K. Sonkar, Jagadish Swamy, Azaj Ahmed, Anjali A. Sharathkumar, Gary L. Pierce, Sanjana Dayal   +6 more
doaj   +2 more sources

Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Michael T. Stobb, Keith B. Neeves, Dougald M. Monroe, Suzanne S. Sindi, Karin Leiderman, Aaron L. Fogelson   +5 more
doaj   +2 more sources

Elevated tissue factor pathway inhibitor delays thrombin generation in COVID-19 but is not associated with clinical outcomes [PDF]

Blood Vessels, Thrombosis & Hemostasis
: Plasma levels of tissue factor pathway inhibitor (TFPI) are elevated in many patients with COVID-19 but the role of TFPI in COVID-19 coagulopathy remains elusive.
Alicia S. Eustes, Meena Kumari Palani Kumar, Julie A. Peterson, Alan E. Mast, Steven R. Lentz, Sanjana Dayal   +5 more
doaj   +2 more sources

The effect of combined oral contraceptives on thrombin generation assessed on ST Genesia– a paired clinical study [PDF]

Thrombosis Journal
Background Treatment with combined oral contraceptives (COC) is associated with an increased risk of venous thromboembolism. Several changes of coagulant and anticoagulant factors induced by ethinyloestradiol during treatment with COC, have been ...
Jesper Strandberg, Inger Lise Gade, Jette Nybo, Janus Nikolaj Laust Thomsen, Søren Risom Kristensen   +4 more
doaj   +2 more sources

Inhibition of Intrinsic Thrombin Generation

Drug Target Insights, 2006
Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief
doaj   +4 more sources

Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms. [PDF]

Res Pract Thromb Haemost
Arisz RA, Bakker B, van den Ham R, Ahmed A, Eikenboom JCJ, Schols SEM, de Maat MPM, SYMPHONY consortium@SYMPHONY_NL.   +7 more
europepmc   +3 more sources