Results 11 to 20 of about 3,896,793 (331)

Inhibition of Intrinsic Thrombin Generation

Drug Target Insights, 2006
Background The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief MD
doaj   +5 more sources

Thrombin generation measurement using the ST Genesia Thrombin Generation System in a cohort of healthy adults: Normal values and variability [PDF]

Research and Practice in Thrombosis and Haemostasis, 2019
Thrombin generation (TG) assays evaluate the balance between pro‐ and anticoagulant forces, to better assess bleeding and thrombotic risks. Although TG readouts obtained with the calibrated automated TG have been investigated in multiple clinical ...
S. Calzavarini, J. Brodard, Claudia Quarroz, Livia Maire, Raphael Nützi, J. Janković, L. Rotondo, E. Giabbani, G. Fiedler, M. Nagler, A. Angelillo-Scherrer   +10 more
semanticscholar   +2 more sources

Analysis of thrombin generation in plasma [PDF]

Computers in Biology and Medicine, 1994
Thrombin is the central enzyme of haemostasis. Information on the production and inhibition of thrombin in plasma is important for evaluating the state of the coagulation system. Measurement of thrombin generation in plasma using small oligopeptide chromogenic substrates gives rise to a signal that not only reflects the enzymatic activity of free ...
Kessels, Han, Willems, George, Hemker, H. Coenraad   +2 more
openaire   +4 more sources

Thrombin generation, a function test of the haemostaticthrombotic system [PDF]

Thrombosis and Haemostasis, 2006
SummaryBy the use of a fluorogenic thrombin substrate and continuous calibration of each individual sample, it is now possible to obtain a thrombin generation (TG) curve (or thrombogram) in plasma, with or without platelets, in an easy routine procedure at high throughput and with an acceptable experimental error (< 5%). Evidence is growing that the
Raed Al Dieri, S Beguin, H C Hemker
exaly   +4 more sources

Thrombin Generation in Acute Ischaemic Stroke [PDF]

Stroke Research and Treatment, 2016
Introduction. Stroke remains a global leading cause of death and disability. Traditional description of plasma biology in the aftermath of acute ischaemic stroke favours development of hypercoagulability, resulting from complex interplay between plasma ...
Ibrahim O. Balogun, Lara N. Roberts, Raj Patel, Rohan Pathansali, Lalit Kalra, Roopen Arya   +5 more
doaj   +2 more sources

Elevated tissue factor pathway inhibitor delays thrombin generation in COVID-19 but is not associated with clinical outcomes [PDF]

Blood Vessels, Thrombosis & Hemostasis
: Plasma levels of tissue factor pathway inhibitor (TFPI) are elevated in many patients with COVID-19 but the role of TFPI in COVID-19 coagulopathy remains elusive.
Alicia S. Eustes, Meena Kumari Palani Kumar, Julie A. Peterson, Alan E. Mast, Steven R. Lentz, Sanjana Dayal   +5 more
doaj   +2 more sources

Data management in Thrombin Generation

Thrombosis Research, 2013
To obtain a thrombin generation (TG) curve from the conversion of added fluorogenic substrate, thrombin concentrations are to be derived from the observed velocity of increase of fluorescence (dF/dt). The relation between velocity and thrombin concentration varies during the experiment because substrate is consumed and because fluorescence is not ...
Hemker, H. Coenraad, Kremers, R.
openaire   +3 more sources

The effect of combined oral contraceptives on thrombin generation assessed on ST Genesia– a paired clinical study [PDF]

Thrombosis Journal
Background Treatment with combined oral contraceptives (COC) is associated with an increased risk of venous thromboembolism. Several changes of coagulant and anticoagulant factors induced by ethinyloestradiol during treatment with COC, have been ...
Jesper Strandberg, Inger Lise Gade, Jette Nybo, Janus Nikolaj Laust Thomsen, Søren Risom Kristensen   +4 more
doaj   +2 more sources

Assessment of Thrombin Generation

European Oncology & Haematology, 2010
Thrombin plays a central role in haemostasis through both procoagulant and anticoagulant functions. Although measurement of thrombin generation in the laboratory has been possible for many years, recent advances in understanding a wider scope of physiological roles of thrombin as well as improvements in technology have resulted in methods that are less
Adams, MJ (15509435)
openaire   +2 more sources

Thrombin generation assays are versatile tools in blood coagulation analysis: A review of technical features, and applications from research to laboratory routine

Journal of Thrombosis and Haemostasis, 2021
Thrombin is the pivotal enzyme in the biochemistry of secondary hemostasis crucial to maintaining homeostasis of hemostasis. In contrast to routine coagulation tests (PT or aPTT) or procoagulant or anticoagulant factor assays (e.g.
F. Depasse, N. Binder, J. Mueller, T. Wissel, S. Schwers, M. Germer, Björn Hermes, P. Turecek   +7 more
semanticscholar   +1 more source