Results 11 to 20 of about 2,633,554 (103)

Inhibition of Intrinsic Thrombin Generation

Drug Target Insights, 2006
Background: The contact phase of coagulation is of physiologic/pathophysiologic importance, whenever unphysiologic polynegative substances such as cell fragments (microparticles) get in contact with blood.
Thomas W. Stief
doaj   +3 more sources

The clinical utility of thrombin generation [PDF]

, 2011
PhDThe Calibrated Automated Thrombogram (CAT) thrombin generation assay is a technique that allows the characterisation of an individual’s capacity to produce thrombin in response to a procoagulant stimulus. As such it is a global screening test for both
Bevan, Shaun Patrick
core   +4 more sources

Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy

Frontiers in Cardiovascular Medicine, 2021
Background: Patients using dual antiplatelet therapy after percutaneous coronary intervention are at risk for bleeding. It is currently unknown whether thrombin generation can be used to identify patients receiving dual antiplatelet therapy with ...
C. P. D. M. de Breet, C. P. D. M. de Breet, S. Zwaveling, S. Zwaveling, M. J. A. Vries, R. G. van Oerle, Y. M. C. Henskens, A. W. J. van't Hof, A. W. J. van't Hof, P. E. J. van der Meijden, L. Veenstra, H. ten Cate, H. ten Cate, R. H. Olie, R. H. Olie   +14 more
doaj   +1 more source

Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma

Scientific Reports, 2023
Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo, Claus V. B. Hviid, Ole Brink, Svend Juul, Lars C. Borris, Anne-Mette Hvas   +5 more
doaj   +1 more source

From principle to practice: bridging the gap in patient profiling. [PDF]

PLoS ONE, 2013
The standard clinical coagulation assays, activated partial thromboplastin time (aPTT) and prothrombin time (PT) cannot predict thrombotic or bleeding risk.
Jonathan H Foley, Thomas Orfeo, Anetta Undas, Kelley C McLean, Ira M Bernstein, Georges-Etienne Rivard, Kenneth G Mann, Stephen J Everse, Kathleen E Brummel-Ziedins   +8 more
doaj   +1 more source

Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project. [PDF]

PLoS ONE, 2016
BACKGROUND:Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify ...
Laura Martin-Fernandez, Andrey Ziyatdinov, Marina Carrasco, Juan Antonio Millon, Angel Martinez-Perez, Noelia Vilalta, Helena Brunel, Montserrat Font, Anders Hamsten, Juan Carlos Souto, José Manuel Soria   +10 more
doaj   +1 more source

Automated Thrombin Generation Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements [PDF]

, 2021
Background: The thrombin generation assay (TG) is a promising approach to measure the degree of anticoagulation in patients treated with direct oral anticoagulants (DOAC).
Gerber, B., Cédric Bovet, Mendez, Adriana, Mendez, A., Walter A. Wuillemin, Adriana Mendez, Wuillemin, W.A., Studt, J.D., Michael Nagler, Studt, Jan-Dirk, Alberio, Lorenzo, Alberio, L., Schmidt, Adrian, Tamana Meihandoest, Maeder, G.M., Lorenzo Alberio, Bovet, C., Adrian Schmidt, Meihandoest, T., Maeder, Gabriela Monika, Schmidt, A., Nagler, M., Meihandoest, Tamana, Pierre Fontana, Graf, Lukas, Lukas Graf, Gerber, Bernhard, Bernhard Gerber, Sauter, Thomas C, Thomas C. Sauter, Graf, L., Jan-Dirk Studt, Gabriela Monika Maeder, Fontana, P., Nagler, Michael, Sauter, T.C., Fontana, Pierre, Bovet, Cédric, Wuillemin, Walter A   +38 more
core   +2 more sources

Thrombin generation in the Glasgow Myocardial Infarction Study. [PDF]

PLoS ONE, 2013
BACKGROUND: Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to myocardial infarction (MI) we explored thrombin generation analysis in plasma from ...
Machiel Smid, Arne W J H Dielis, Henri M H Spronk, Ann Rumley, Rene van Oerle, Mark Woodward, Hugo ten Cate, Gordon Lowe   +7 more
doaj   +1 more source

Evaluation of the hemostatic potential at coronary artery bypass surgery during long-term aspirin therapy [PDF]

Терапевтический архив, 2016
Aim. To estimate thrombin generation test parameters in patients with coronary heart disease during coronary artery bypass surgery under extracorporeal circulation after transfusion of donor platelet concentrates during long-term therapy with ...
O V Gruzdeva, E V Fanaskova, O E Akbasheva, E G Uchasova, T Yu Penskaya, G P Plotnikov, Yu A Dyleva, K E Krivoshapova, O L Barbarash   +8 more
doaj   +1 more source

Microparticles and Nucleosomes Are Released From Parenchymal Cells Destroyed After Injury in a Rat Model of Blunt Trauma

Clinical and Applied Thrombosis/Hemostasis, 2020
We investigated the relationships between circulating procoagulants and trauma severity, including cellular destruction, and the effects of thrombin generation on procoagulants in a rat blunt trauma model. The rats were subjected to tumbling blunt trauma,
Mineji Hayakwa MD, PhD, Takayoshi Ooyasu MD, Yoshihiro Sadamoto MD, Tomoyo Saito MD, PhD, Tomonao Yoshida MD, Kenichi Katabami MD, Takeshi Wada MD, PhD, Kunihiko Maekawa MD, Masahiro Ieko MD, PhD   +8 more
doaj   +1 more source