Results 1 to 10 of about 162,133 (299)

Thrombin-induced platelet aggregation −effect of dabigatran using automated platelet aggregometry−

Platelets, 2020
Dabigatran, a direct oral thrombin inhibitor, has two therapeutic effects: anticoagulation; and antiplatelet activity. In the clinical field, evaluation of the effect of dabigatran on thrombin-induced platelet aggregation is difficult because of fibrin ...
Mie Shimizu, Tatsunori Natori, Keisuke Tsuda, Makiko Yoshida, Asami Kamada, Kiyotaka Oi, Yoko Ishigaku, Kazumasa Oura, Shinsuke Narumi, Masahiro Yamamoto, Yasuo Terayama   +10 more
doaj   +1 more source

Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C

Journal of Pharmacological Sciences, 2022
Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs)
Akihiro Okamura, Junichiro Miake, Takuya Tomomori, Aiko Takami, Tatsuya Sawano, Masaru Kato, Kazuyoshi Ogura, Daiki Tsujimoto, Shunsuke Kawatani, Kurniawan Priyono Agung, Tomomi Notsu, Ichiro Hisatome, Kazuhiro Yamamoto, Takeshi Imamura   +13 more
doaj   +1 more source

Complement and Coagulation System Crosstalk in Synaptic and Neural Conduction in the Central and Peripheral Nervous Systems

Biomedicines, 2021
Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant ...
Shani Berkowitz, Joab Chapman, Amir Dori, Shany Guly Gofrit, Nicola Maggio, Efrat Shavit-Stein   +5 more
doaj   +1 more source

Factor Xa or thrombin: Is thrombin a better target? [PDF]

Journal of Thrombosis and Haemostasis, 2007
The limitations of the vitamin K antagonists have prompted the development of new oral anticoagulants that target specific clotting enzymes. Most of the novel agents currently under development target either thrombin or factor Xa. As the final effector of blood coagulation and the most potent platelet agonist, thrombin is a logical target for new oral ...
openaire   +2 more sources

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +1 more source

Regulation and Dysregulation of Thrombin Activity

Southeastern European Medical Journal, 2021
Thrombin is the enzyme of the haemostasis system that stands at the crossroads between the coagulation cascade and coagulation inhibition by protein C, between plasma coagulation factors and cells involved in haemostasis and between haemostasis and the ...
Daria Korolova
doaj   +1 more source

Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.

PLoS ONE, 2020
Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura, Haruta Mogami, Kaori Moriuchi, Yoshitsugu Chigusa, Masaki Mandai, Eiji Kondoh   +5 more
doaj   +1 more source

Inhibition of thrombin, an unexplored function of retinoic acid

Biochemistry and Biophysics Reports, 2019
Retinoic acid, a derivative of vitamin A, is known to possess in vivo anti-inflammatory, anti-platelet and fibrinolytic activities. We have investigated the in vitro thrombin and platelet aggregation inhibitory activities of vitamin A (retinol) and its ...
Tirumala Harikrishna Anantha Krishna, Subban Kamalraj, Maheswaraiah Anikisetty, K. Akhilender Naidu, William R. Surin, Chelliah Jayabaskaran   +5 more
doaj   +1 more source

A General, Label-Free and Homogeneous Electrochemical Strategy for Probing of Protease Activity and Screening of Inhibitor

Micromachines, 2022
Proteases play a critical role in regulating various physiological processes from protein digestion to wound healing. Monitoring the activity of proteases and screening their inhibitors as potential drug molecules are of great importance for the early ...
Yunxiao Feng, Gang Liu, Fan Zhang, Jianwen Liu, Ming La, Ning Xia   +5 more
doaj   +1 more source

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.

PLoS ONE, 2013
Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early ...
Jenell R Smith, Peter P Syre, Shaina A Oake, Kristen J Nicholson, Christine L Weisshaar, Katrina Cruz, Robert Bucki, Bethany C Baumann, Paul A Janmey, Beth A Winkelstein   +9 more
doaj   +1 more source