Results 1 to 10 of about 145,978 (310)
Canadian Journal of Biochemistry and Physiology, 1959 Purified thrombin-C loses its clotting power upon acetylation. The thrombin-E which is produced during the acetylation has approximately twice the proteolytic activity as the original thrombin-C. Evidently amino groups are not necessary to have thrombin-E activity, but if o-acyl groups are also produced the enzyme does not hydrolyze p ...
R H, LANDABURU, W H, SEEGERS
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Clinical and Experimental Pharmacology and Physiology, 1994
SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
P M, Dennington, M C, Berndt
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SUMMARY1. The thrombin receptor has now been cloned and found to be a member of the G‐protein‐coupled seven‐transmembrane domain receptor family.2. The receptor has been detected directly in platelets, endothelial cells and smooth muscle cells and studies using receptor‐derived peptides have demonstrated that this receptor may be the one responsible ...
P M, Dennington, M C, Berndt
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Thrombin and Thrombin‐Incorporated Biomaterials for Disease Treatments
Advanced Healthcare Materials, 2023AbstractThrombin, a coagulation‐inducing protease, has long been used in the hemostatic field. During the past decades, many other therapeutic uses of thrombin have been developed. For instance, burn treatment, pseudoaneurysm therapy, wound management, and tumor vascular infarction (or tumor vasculature blockade therapy) can all utilize the unique and ...
Qiong‐Dan Zhang +3 more
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2013
Generation of thrombin has been established as the critical process leading to coagulation in vivo. Indeed, ex vivo markers of thrombin generation in patients have been useful in detecting thrombosis, while many standard global clot-time tests of haemostasis in blood or plasma samples are simple endpoint measures of the potential to generate thrombin ...
Leslie R, Berry, Anthony K C, Chan
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Generation of thrombin has been established as the critical process leading to coagulation in vivo. Indeed, ex vivo markers of thrombin generation in patients have been useful in detecting thrombosis, while many standard global clot-time tests of haemostasis in blood or plasma samples are simple endpoint measures of the potential to generate thrombin ...
Leslie R, Berry, Anthony K C, Chan
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Blood, 2005
AbstractFollowing initiation of coagulation as part of the hemostatic response to injury, thrombin is generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase complex. Thrombin then has multiple roles. The way in which thrombin interacts with its many substrates has been carefully scrutinized in the past decades, but
David A, Lane +2 more
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AbstractFollowing initiation of coagulation as part of the hemostatic response to injury, thrombin is generated from its inactive precursor prothrombin by factor Xa as part of the prothrombinase complex. Thrombin then has multiple roles. The way in which thrombin interacts with its many substrates has been carefully scrutinized in the past decades, but
David A, Lane +2 more
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Trends in Cardiovascular Medicine, 1998
Thrombin plays both procoagulant and anticoagulant roles in the blood coagulation cascade. This dual role is influenced allosterically by the binding of Na(+) near the primary specificity pocket of the enzyme. Recent findings demonstrate that it is possible to engineer recombinant thrombins that have practically lost anticoagulant activity but retain ...
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Thrombin plays both procoagulant and anticoagulant roles in the blood coagulation cascade. This dual role is influenced allosterically by the binding of Na(+) near the primary specificity pocket of the enzyme. Recent findings demonstrate that it is possible to engineer recombinant thrombins that have practically lost anticoagulant activity but retain ...
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On the inactivation of thrombin
Experientia, 1946Es wird eine Analogie zwischen der bekannten Thrombininaktivierung in Serum und dem Inaktivierungsprozes von Thrombin durch gebundenes Heparin gezeigt. Es ist moglich, das die Thrombininaktivierungsfahigkeit des Serums dem gebundenen Heparin zu verdanken ist.
K, LAKI, L, LORAND
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Thrombosis and Haemostasis, 1995
A model of thrombin interaction with distinct substrates or ligands has been derived from the crystallographic studies of thrombin-inhibitors complexes, and buttressed by functional studies with mutant thrombins, thrombin proteolytic derivatives or antibodies against thrombin.
M C, Guillin +3 more
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A model of thrombin interaction with distinct substrates or ligands has been derived from the crystallographic studies of thrombin-inhibitors complexes, and buttressed by functional studies with mutant thrombins, thrombin proteolytic derivatives or antibodies against thrombin.
M C, Guillin +3 more
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Chest, 2003
The generation of the enzyme thrombin from its precursor prothrombin is the central event of the blood coagulation process, which is essential to hemostasis and the culprit in thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex
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The generation of the enzyme thrombin from its precursor prothrombin is the central event of the blood coagulation process, which is essential to hemostasis and the culprit in thrombosis. Thrombin is produced by a complex series of proteolytic events that are initiated when cryptic tissue factor interacts with plasma factor VIIa to initiate the complex
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Archives of Biochemistry and Biophysics, 1961
Seegers citrate thrombin was prepared from bovine plasma and purified on IRC-50 (XE-64) resin columns at room temperature. The preparation was examined in the ultracentrifuge to determine the sedimentation coefficient and Archibald molecular weight. All measurements were made at 20 °C.
M A, COHLY, H A, SCHERAGA
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Seegers citrate thrombin was prepared from bovine plasma and purified on IRC-50 (XE-64) resin columns at room temperature. The preparation was examined in the ultracentrifuge to determine the sedimentation coefficient and Archibald molecular weight. All measurements were made at 20 °C.
M A, COHLY, H A, SCHERAGA
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