Results 1 to 10 of about 123,596 (163)
Molecular Aspects of Medicine, 2008 Thrombin is a Na+-activated, allosteric serine protease that plays opposing functional roles in blood coagulation. Binding of Na+ is the major driving force behind the procoagulant, prothrombotic and signaling functions of the enzyme, but is dispensable for cleavage of the anticoagulant protein C.
Enrico di Cera
exaly +3 more sources
Factor Xa or thrombin: Is thrombin a better target? [PDF]
Journal of Thrombosis and Haemostasis, 2007 The limitations of the vitamin K antagonists have prompted the development of new oral anticoagulants that target specific clotting enzymes. Most of the novel agents currently under development target either thrombin or factor Xa. As the final effector of blood coagulation and the most potent platelet agonist, thrombin is a logical target for new oral ...
J I Weitz
exaly +3 more sources
High thrombin activity associated with crohn’s disease induces microbiota pathogenicity contributing to mucosal inflammation [PDF]
Gut MicrobesThrombin is a serine protease produced by the intestinal epithelium that contributes to mucosal homeostasis by limiting microbial encroachment.
Guillaume Le Cosquer +20 more
doaj +2 more sources
PLoS Computational Biology, 2022 Thrombin is an enzyme produced during blood coagulation that is crucial to the formation of a stable clot. Thrombin cleaves soluble fibrinogen into fibrin, which polymerizes and forms an insoluble, stabilizing gel around the growing clot.
Michael A Kelley, Karin Leiderman
doaj +3 more sources
Journal of Genetic Engineering and Biotechnology, 2023 Background Thrombin is the most important enzyme in the hemostatic process by permitting rapid and localized coagulation in case of tissue damage. Camel thrombin is the natural and proper target enzyme for the previously purified camel tick salivary ...
Mahmoud A. Ibrahim, Hassan M. M. Masoud
doaj +1 more source
Negatively charged phospholipids stimulate factor XI activation by thrombin
Thrombosis Update, 2021 Introduction: Coagulation factor XI (FXI) is the zymogen of the serine-protease FXIa, which contributes to thrombin formation by activating factor IX.
Farida Omarova +3 more
doaj +1 more source
Structure and behavior of human α-thrombin upon ligand recognition: thermodynamic and molecular dynamics studies. [PDF]
PLoS ONE, 2011 Thrombin is a serine proteinase that plays a fundamental role in coagulation. In this study, we address the effects of ligand site recognition by alpha-thrombin on conformation and energetics in solution.
Vivian de Almeira Silva +6 more
doaj +1 more source
Scientific Reports, 2023 Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo +5 more
doaj +1 more source
Impact of hormone-associated resistance to activated protein C on the thrombotic potential of oral contraceptives: a prospective observational study. [PDF]
PLoS ONE, 2014 The increased thrombotic risk of oral contraceptives (OC) has been attributed to various alterations of the hemostatic system, including acquired resistance to activated protein C (APC).
Heiko Rühl +8 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Aims: To explore the role of the Sphingosine 1-Phosphate (S1P)/Receptor2 (S1PR2) pathway in thrombin-induced hyperpermeability (TIP) and to test whether bivalirudin can reverse TIP via the S1P-S1PRs pathway.Methods and Results: Using western blot, we ...
Haowen Ye +9 more
doaj +1 more source