Results 31 to 40 of about 145,978 (310)

Structural Features and PF4 Functions that Occur in Heparin-Induced Thrombocytopenia (HIT) Complicated by COVID-19

Antibodies, 2020
Platelet factor 4 (PF4, CXCL4) is a small chemokine protein released by activated platelets. Although a major physiological function of PF4 is to promote blood coagulation, this cytokine is involved in innate and adaptive immunity in events when ...
Zheng Cai, Mark I. Greene, Zhiqiang Zhu, Hongtao Zhang   +3 more
doaj   +1 more source

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.

PLoS ONE, 2013
Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early ...
Jenell R Smith, Peter P Syre, Shaina A Oake, Kristen J Nicholson, Christine L Weisshaar, Katrina Cruz, Robert Bucki, Bethany C Baumann, Paul A Janmey, Beth A Winkelstein   +9 more
doaj   +1 more source

Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity

Pharmaceuticals, 2022
New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target.
Calvin Dunker, Lukas Imberg, Alena I. Siutkina, Catharina Erbacher, Constantin G. Daniliuc, Uwe Karst, Dmitrii V. Kalinin   +6 more
doaj   +1 more source

Bare magnetic nanoparticles as fluorescence quenchers for detection of thrombin [PDF]

, 2015
Rapid and sensitive detection of thrombin has very important significance in clinical diagnosis. In this work, bare magnetic iron oxide nanoparticles (magnetic nanoparticles) without any modification were used as fluorescence quenchers. In the absence of
Dong, Tingting, Yu, Jiemiao, Liang, Xiangfeng, Liu, Huizhou, Yang, Liangrong   +4 more
core   +1 more source

Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons

Neurobiology of Disease, 2008
Since Src kinase inhibitors decrease brain injury produced by intracerebral hemorrhage (ICH) and thrombin is activated following ICH, this study determined whether Src kinase inhibitors decrease thrombin-induced brain injury.
Da-Zhi Liu, Xi-Yuan Cheng, Bradley P. Ander, Huichun Xu, Ryan R. Davis, Jeffrey P. Gregg, Frank R. Sharp   +6 more
doaj   +1 more source

The role of thrombin in early-onset seizures

Frontiers in Cellular Neuroscience, 2023
A variety of clinical observations and studies in animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.
Alina Savotchenko, Mariia Klymenko, Mariia Shypshyna, Dmytro Isaev   +3 more
doaj   +1 more source

PURIFICATION OF THROMBIN [PDF]

Journal of General Physiology, 1942
1. Under certain conditions crude prothrombin changes to thrombin without the addition of extraneous activators and in the absence of ionic calcium. 2. Thrombin is soluble in 0.45 saturated ammonium sulfate, whereas crude prothrombin is not. 3.
openaire   +2 more sources

Thrombin induced connective tissue growth factor expression in rat vascular smooth muscle cells via the PAR-1/JNK/AP-1 pathway

, 2014
Aim: To investigate the signaling pathways involved in thrombin-induced connective tissue growth factor (CTGF) expression in rat vascular smooth muscle cells (VSMCs). Methods: Experiments were preformed on primary rat aortic smooth muscle cells (RASMCs)
Ko, Wen-chin;Chen, Bing-chang;Hsu, Ming-jen;Tsai, Chia-ti;Hong, Chuang-ye;Lin, Chien-huang, 蔡佳醍   +1 more
core   +1 more source

Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study

Research and Practice in Thrombosis and Haemostasis
Background: The thrombin dynamics method has been used as an add-on analysis method for the thrombin generation test over the past years to study the balance between pro- and anticoagulant pathways.
Amalia De Curtis, Romy de Laat-Kremers, Simona Costanzo, Augusto Di Castelnuovo, Marisa Ninivaggi, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni   +51 more
doaj   +1 more source

Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin

Biomolecules, 2019
Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova, Valeriia A. Legatova, Rugiya Sh. Alieva, Arthur O. Zalevsky, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov   +6 more
doaj   +1 more source