Results 31 to 40 of about 203,879 (305)

Structural Features and PF4 Functions that Occur in Heparin-Induced Thrombocytopenia (HIT) Complicated by COVID-19

Antibodies, 2020
Platelet factor 4 (PF4, CXCL4) is a small chemokine protein released by activated platelets. Although a major physiological function of PF4 is to promote blood coagulation, this cytokine is involved in innate and adaptive immunity in events when ...
Zheng Cai, Mark I. Greene, Zhiqiang Zhu, Hongtao Zhang   +3 more
doaj   +1 more source

Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity

Pharmaceuticals, 2022
New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target.
Calvin Dunker, Lukas Imberg, Alena I. Siutkina, Catharina Erbacher, Constantin G. Daniliuc, Uwe Karst, Dmitrii V. Kalinin   +6 more
doaj   +1 more source

PURIFICATION OF THROMBIN [PDF]

Journal of General Physiology, 1942
1. Under certain conditions crude prothrombin changes to thrombin without the addition of extraneous activators and in the absence of ionic calcium. 2. Thrombin is soluble in 0.45 saturated ammonium sulfate, whereas crude prothrombin is not. 3.
openaire   +2 more sources

Prothrombin conversion accelerates with increasing age in women but not in men: findings from the Moli-sani Cohort Study

Research and Practice in Thrombosis and Haemostasis
Background: The thrombin dynamics method has been used as an add-on analysis method for the thrombin generation test over the past years to study the balance between pro- and anticoagulant pathways.
Amalia De Curtis, Romy de Laat-Kremers, Simona Costanzo, Augusto Di Castelnuovo, Marisa Ninivaggi, Chiara Cerletti, Giovanni de Gaetano, Maria Benedetta Donati, Licia Iacoviello, Bas de Laat, Licia Iacoviello, Giovanni de Gaetano, Maria Benedetta Donati, Chiara Cerletti, Marialaura Bonaccio, Americo Bonanni, Simona Costanzo, Amalia De Curtis, Augusto Di Castelnuovo, Alessandro Gialluisi, Francesco Gianfagna, Mariarosaria Persichillo, Jos Vermylen, Renzo Pegoraro, Antonio G. Spagnolo, Deodato Assanelli, Livia Rago, Simona Costanzo, Sabatino Orlandi, Teresa Panzera, Augusto Di Castelnuovo, Marialaura Bonaccio, Francesca Bracone, Simona Costanzo, Giuseppe Di Costanzo, Simona Esposito, Alessandro Gialluisi, Anwal Ghulam, Francesco Gianfagna, Martina Morelli, Maria Loreto Muñoz Venegas, Antonietta Pepe, Emilia Ruggiero, Amalia De Curtis, Concetta Civitillo, Alisia Cretella, Sara Magnacca, Mariarosaria Persichillo, Francesca Bracone, Giuseppe Di Costanzo, Martina Morelli, Americo Bonanni   +51 more
doaj   +1 more source

Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons

Neurobiology of Disease, 2008
Since Src kinase inhibitors decrease brain injury produced by intracerebral hemorrhage (ICH) and thrombin is activated following ICH, this study determined whether Src kinase inhibitors decrease thrombin-induced brain injury.
Da-Zhi Liu, Xi-Yuan Cheng, Bradley P. Ander, Huichun Xu, Ryan R. Davis, Jeffrey P. Gregg, Frank R. Sharp   +6 more
doaj   +1 more source

The role of thrombin in early-onset seizures

Frontiers in Cellular Neuroscience, 2023
A variety of clinical observations and studies in animal models of temporal lobe epilepsy (TLE) reveal dysfunction of blood-brain barrier (BBB) during seizures.
Alina Savotchenko, Mariia Klymenko, Mariia Shypshyna, Dmytro Isaev   +3 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Effects of Add‐On Icosapent Ethyl With Standard Treatment on Functional Outcomes and Inflammatory Biomarkers in Acute Ischemic Stroke: A Blinded Randomized Controlled Trial

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Ischemic stroke, a major cause of mortality and long‐term disability, results from the abrupt cessation of cerebral blood flow due to vascular occlusion or rupture. Icosapent Ethyl (EPA‐EE), approved for hypertriglyceridemia, has anti‐inflammatory and antithrombotic properties that may lessen ischemic damage.
Mitra Mahmoudi Meymand, Seyed Hossein Aghamiri, Saeed Mohmammad Soleymani, Shadiyeh Bararpoor Poshkohi, Samaneh Masoudi, Hadi Esmaily   +5 more
wiley   +1 more source

Light‐Assisted 3D Printing Techniques and Photocrosslinking Strategies: Recent Advances in Musculoskeletal Tissue Engineering

Advanced Engineering Materials, EarlyView.
In this review, the current state of light‐assisted 3D printing as it pertains to engineering musculoskeletal tissues including bone, cartilage, skeletal muscle, tendon, and ligaments is summarized. Common printing techniques, photoreactive materials, and study design choices are compiled and reviewed.
Meagan Morgan, Bin Zhang, Roger Narayan
wiley   +1 more source

Putative Mechanisms Underlying High Inhibitory Activities of Bimodular DNA Aptamers to Thrombin

Biomolecules, 2019
Nucleic acid aptamers are prospective molecular recognizing elements. Similar to antibodies, aptamers are capable of providing specific recognition due to their spatial structure.
Elena G. Zavyalova, Valeriia A. Legatova, Rugiya Sh. Alieva, Arthur O. Zalevsky, Vadim N. Tashlitsky, Alexander M. Arutyunyan, Alexey M. Kopylov   +6 more
doaj   +1 more source