Results 21 to 30 of about 158,309 (195)

PURIFICATION OF THROMBIN [PDF]

Journal of General Physiology, 1942
1. Under certain conditions crude prothrombin changes to thrombin without the addition of extraneous activators and in the absence of ionic calcium. 2. Thrombin is soluble in 0.45 saturated ammonium sulfate, whereas crude prothrombin is not. 3.
openaire   +2 more sources

Inhibition of thrombin, an unexplored function of retinoic acid

Biochemistry and Biophysics Reports, 2019
Retinoic acid, a derivative of vitamin A, is known to possess in vivo anti-inflammatory, anti-platelet and fibrinolytic activities. We have investigated the in vitro thrombin and platelet aggregation inhibitory activities of vitamin A (retinol) and its ...
Tirumala Harikrishna Anantha Krishna, Subban Kamalraj, Maheswaraiah Anikisetty, K. Akhilender Naidu, William R. Surin, Chelliah Jayabaskaran   +5 more
doaj   +1 more source

Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.

PLoS ONE, 2020
Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura, Haruta Mogami, Kaori Moriuchi, Yoshitsugu Chigusa, Masaki Mandai, Eiji Kondoh   +5 more
doaj   +1 more source

A General, Label-Free and Homogeneous Electrochemical Strategy for Probing of Protease Activity and Screening of Inhibitor

Micromachines, 2022
Proteases play a critical role in regulating various physiological processes from protein digestion to wound healing. Monitoring the activity of proteases and screening their inhibitors as potential drug molecules are of great importance for the early ...
Yunxiao Feng, Gang Liu, Fan Zhang, Jianwen Liu, Ming La, Ning Xia   +5 more
doaj   +1 more source

Thrombin-antithrombin complexes in envenomated dogs and controls.

, 2022
Concentrations of thrombin-antithrombin (TAT) complexes in envenomated dogs at five timepoints after bite (black dots) and controls (green dots). T1 = presentation, T2 = 12 hours, T3 = 24 hours, T4 = 36 hours and T5 = 15 days after bite.* indicates P < 0.
Hannah J. Harjen (10587731), Susanna Solbak (12107152), Runa Rørtveit (10298409), Marit Hellum (91013), Elena R. Moldal (10587749), Carola E. Henriksson (4436896), Sandip M. Kanse (12107155), Malin Oscarson (12107149), Kristin P. Anfinsen (10587746)   +8 more
core   +1 more source

Salmon and human thrombin differentially regulate radicular pain, glial-induced inflammation and spinal neuronal excitability through protease-activated receptor-1.

PLoS ONE, 2013
Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early ...
Jenell R Smith, Peter P Syre, Shaina A Oake, Kristen J Nicholson, Christine L Weisshaar, Katrina Cruz, Robert Bucki, Bethany C Baumann, Paul A Janmey, Beth A Winkelstein   +9 more
doaj   +1 more source

Src kinase inhibition decreases thrombin-induced injury and cell cycle re-entry in striatal neurons

Neurobiology of Disease, 2008
Since Src kinase inhibitors decrease brain injury produced by intracerebral hemorrhage (ICH) and thrombin is activated following ICH, this study determined whether Src kinase inhibitors decrease thrombin-induced brain injury.
Da-Zhi Liu, Xi-Yuan Cheng, Bradley P. Ander, Huichun Xu, Ryan R. Davis, Jeffrey P. Gregg, Frank R. Sharp   +6 more
doaj   +1 more source

Structural Features and PF4 Functions that Occur in Heparin-Induced Thrombocytopenia (HIT) Complicated by COVID-19

Antibodies, 2020
Platelet factor 4 (PF4, CXCL4) is a small chemokine protein released by activated platelets. Although a major physiological function of PF4 is to promote blood coagulation, this cytokine is involved in innate and adaptive immunity in events when ...
Zheng Cai, Mark I. Greene, Zhiqiang Zhu, Hongtao Zhang   +3 more
doaj   +1 more source

Safety of topical thrombins: the ongoing debate

Patient Safety in Surgery, 2009
Until recently, only bovine-derived thrombin was available for use as a stand-alone topical hemostat or as a component of other hemostatic devices. Concerns over a number of case reports of immune-mediated coagulopathies associated with the use of bovine-
Lomax Christopher
doaj   +1 more source

Pyrazole-Based Thrombin Inhibitors with a Serine-Trapping Mechanism of Action: Synthesis and Biological Activity

Pharmaceuticals, 2022
New antithrombotic drugs are needed to combat thrombosis, a dangerous pathology that causes myocardial infarction and ischemic stroke. In this respect, thrombin (FIIa) represents an important drug target.
Calvin Dunker, Lukas Imberg, Alena I. Siutkina, Catharina Erbacher, Constantin G. Daniliuc, Uwe Karst, Dmitrii V. Kalinin   +6 more
doaj   +1 more source