Results 21 to 30 of about 203,879 (305)
Haematologica, 2008 Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis +6 more
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Regulation and Dysregulation of Thrombin Activity
Southeastern European Medical Journal, 2021 Thrombin is the enzyme of the haemostasis system that stands at the crossroads between the coagulation cascade and coagulation inhibition by protein C, between plasma coagulation factors and cells involved in haemostasis and between haemostasis and the ...
Daria Korolova
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Thrombin Generation and Cancer: Contributors and Consequences
Cancers, 2019 The high occurrence of cancer-associated thrombosis is associated with elevated thrombin generation. Tumour cells increase the potential for thrombin generation both directly, through the expression and release of procoagulant factors, and indirectly ...
C. Reddel, C. Tan, V. Chen
semanticscholar +1 more source
Scientific Reports, 2017 Cells release diverse types of vesicles constitutively or in response to proliferation, injury, inflammation, or stress. Extracellular vesicles (EVs) are crucial in intercellular communication, and there is emerging evidence for their roles in ...
C. Tripisciano +6 more
semanticscholar +1 more source
Inhibition of thrombin, an unexplored function of retinoic acid
Biochemistry and Biophysics Reports, 2019 Retinoic acid, a derivative of vitamin A, is known to possess in vivo anti-inflammatory, anti-platelet and fibrinolytic activities. We have investigated the in vitro thrombin and platelet aggregation inhibitory activities of vitamin A (retinol) and its ...
Tirumala Harikrishna Anantha Krishna +5 more
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Mechanisms of thrombin-Induced myometrial contractions: Potential targets of progesterone.
PLoS ONE, 2020 Intrauterine bleeding during pregnancy is a major risk factor for preterm birth. Thrombin, the most abundant coagulation factor in blood, is associated with uterine myometrial contraction.
Fumitomo Nishimura +5 more
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Micromachines, 2022 Proteases play a critical role in regulating various physiological processes from protein digestion to wound healing. Monitoring the activity of proteases and screening their inhibitors as potential drug molecules are of great importance for the early ...
Yunxiao Feng +5 more
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PLoS ONE, 2013 Chronic neck pain is a major problem with common causes including disc herniation and spondylosis that compress the spinal nerve roots. Cervical nerve root compression in the rat produces sustained behavioral hypersensitivity, due in part to the early ...
Jenell R Smith +9 more
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Thrombin-Responsive Transcutaneous Patch for Auto-Anticoagulant Regulation
Advances in Materials, 2016 A thrombin-responsive closed-loop patch is developed for prolonged heparin delivery in a feedback-controlled manner. This microneedle-based patch can sense activated thrombin and subsequently releases heparin to prevent coagulation in the blood flow ...
Yuqi Zhang +11 more
semanticscholar +1 more source
Safety of topical thrombins: the ongoing debate
Patient Safety in Surgery, 2009 Until recently, only bovine-derived thrombin was available for use as a stand-alone topical hemostat or as a component of other hemostatic devices. Concerns over a number of case reports of immune-mediated coagulopathies associated with the use of bovine-
Lomax Christopher
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