Results 21 to 30 of about 145,978 (310)
Thrombin-induced platelet aggregation −effect of dabigatran using automated platelet aggregometry−
Platelets, 2020 Dabigatran, a direct oral thrombin inhibitor, has two therapeutic effects: anticoagulation; and antiplatelet activity. In the clinical field, evaluation of the effect of dabigatran on thrombin-induced platelet aggregation is difficult because of fibrin ...
Mie Shimizu +10 more
doaj +1 more source
Dabigatran and Argatroban Diametrically Modulate Thrombin Exosite Function. [PDF]
PLoS ONE, 2016 Thrombin is a highly plastic molecule whose activity and specificity are regulated by exosites 1 and 2, positively-charged domains that flank the active site. Exosite binding by substrates and cofactors regulates thrombin activity by localizing thrombin,
Calvin H Yeh +4 more
doaj +1 more source
Biomedicines, 2021 Complement and coagulation are both key systems that defend the body from harm. They share multiple features and are similarly activated. They each play individual roles in the systemic circulation in physiology and pathophysiology, with significant ...
Shani Berkowitz +5 more
doaj +1 more source
Thrombin-antithrombin complexes in envenomated dogs and controls.
, 2022 Concentrations of thrombin-antithrombin (TAT) complexes in envenomated dogs at five timepoints after bite (black dots) and controls (green dots). T1 = presentation, T2 = 12 hours, T3 = 24 hours, T4 = 36 hours and T5 = 15 days after bite.* indicates P < 0.
Hannah J. Harjen (10587731) +8 more
core +1 more source
Regulation and Dysregulation of Thrombin Activity
Southeastern European Medical Journal, 2021 Thrombin is the enzyme of the haemostasis system that stands at the crossroads between the coagulation cascade and coagulation inhibition by protein C, between plasma coagulation factors and cells involved in haemostasis and between haemostasis and the ...
Daria Korolova
doaj +1 more source
Haematologica, 2008 Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis +6 more
doaj +1 more source
Factor Xa or thrombin: Is thrombin a better target? [PDF]
Journal of Thrombosis and Haemostasis, 2007 The limitations of the vitamin K antagonists have prompted the development of new oral anticoagulants that target specific clotting enzymes. Most of the novel agents currently under development target either thrombin or factor Xa. As the final effector of blood coagulation and the most potent platelet agonist, thrombin is a logical target for new oral ...
openaire +2 more sources
Inhibition of thrombin, an unexplored function of retinoic acid
Biochemistry and Biophysics Reports, 2019 Retinoic acid, a derivative of vitamin A, is known to possess in vivo anti-inflammatory, anti-platelet and fibrinolytic activities. We have investigated the in vitro thrombin and platelet aggregation inhibitory activities of vitamin A (retinol) and its ...
Tirumala Harikrishna Anantha Krishna +5 more
doaj +1 more source
Micromachines, 2022 Proteases play a critical role in regulating various physiological processes from protein digestion to wound healing. Monitoring the activity of proteases and screening their inhibitors as potential drug molecules are of great importance for the early ...
Yunxiao Feng +5 more
doaj +1 more source