Results 21 to 30 of about 2,633,554 (103)

Defining the boundaries of normal thrombin generation: investigations into hemostasis. [PDF]

PLoS ONE, 2012
In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently healthy individuals. The significance of this variability remains obscure, in part because it is the backdrop against which the hemostatic consequences of
Christopher M Danforth, Thomas Orfeo, Stephen J Everse, Kenneth G Mann, Kathleen E Brummel-Ziedins   +4 more
doaj   +1 more source

In vitro reversal of direct factor Xa inhibitors: Direct comparison of andexanet alfa and prothrombin complex concentrates Cofact and Beriplex/Kcentra

Research and Practice in Thrombosis and Haemostasis, 2022
Background Both andexanet alfa and four‐factor prothrombin complex concentrate (4F‐PCC) are clinically applied reversal agents for direct factor Xa inhibitors (FXaIs) in emergency situations. Controversy exists whether 4F‐PCC is as effective as andexanet
Herm Jan M. Brinkman, Marleen Zuurveld, Joost C. M. Meijers   +2 more
doaj   +1 more source

Impaired glucose metabolism is associated with increased thrombin generation potential in patients undergoing angioplasty and stenting

Cardiovascular Diabetology, 2018
Background As a strong platelet agonist on the one hand and key molecule in plasmatic coagulation on the other hand, thrombin connects primary and secondary hemostasis.
Silvia Lee, Cihan Ay, Christoph W. Kopp, Simon Panzer, Thomas Gremmel   +4 more
doaj   +1 more source

Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity. [PDF]

PLoS ONE, 2011
Pre-eclampsia is a complication of pregnancy associated with activation of coagulation. It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could
Chris Gardiner, Dionne S Tannetta, Carol A Simms, Paul Harrison, Christopher W G Redman, Ian L Sargent   +5 more
doaj   +1 more source

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +1 more source

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis. [PDF]

PLoS ONE, 2016
Circulating microparticles (MPs) derived from endothelial cells and blood cells bear procoagulant activity and promote thrombin generation. Thrombin exerts proinflammatory effects mediating the progression of atherosclerosis.
Patrick Horn, Gülsüm Erkilet, Verena Veulemans, Patric Kröpil, Leon Schurgers, Tobias Zeus, Christian Heiss, Malte Kelm, Ralf Westenfeld   +8 more
doaj   +1 more source

The in vitro addition of idarucizumab to plasma samples from patients increases thrombin generation

Scientific Reports, 2021
Dabigatran interferes with many coagulation tests. To overcome this obstacle the use of idarucizumab as an in vitro antidote to dabigatran has been proposed.
Mojca Božič Mijovski, Rickard E. Malmström, Nina Vene, Jovan P. Antovic, Alenka Mavri   +4 more
doaj   +1 more source

The thrombin generation capability of the Chacma baboon (Papio ursinus): implications for haemostatic disease models

Scientific Reports, 2023
Baboon models are often used to investigate haemostatic diseases, such as acquired thrombotic thrombocytopenic purpura or bacterial sepsis-induced disseminated intravascular coagulation, and their potential treatment with novel drugs. Thrombin generation
J. Joubert, S. M. Meiring, W. J. Janse van Rensburg   +2 more
doaj   +1 more source

Thrombin generation in cardiovascular disease and mortality - results from the Gutenberg Health Study

Haematologica, 2019
Thrombin generation may be a potential tool to improve risk stratification for cardiovascular diseases. This study aims to explore the relation between thrombin generation and cardiovascular risk factors, cardiovascular diseases, and total mortality ...
Pauline C.S. van Paridon, Marina Panova-Noeva, Rene van Oerle, Andreas Schultz, Iris M. Hermanns, Jürgen H. Prochaska, Nathalie Arnold, Harald Binder, Irene Schmidtmann, Manfred E. Beutel, Norbert Pfeiffer, Thomas Münzel, Karl J. Lackner, Hugo ten Cate, Philipp S. Wild, Henri M.H. Spronk   +15 more
doaj   +1 more source

Thrombin Generation by Valproate [PDF]

, 2019
Pathological plasmatic thrombin generation can lead to many complications such as thrombotic/atherosclerotic diseases. The contact phase of blood coagulation can be triggered by low plasma concentrations of lipophilic or negatively charged groups.
Mohrez, Morad
core   +1 more source