Results 21 to 30 of about 3,896,793 (331)

DOAC-associated bleeding, hemostatic strategies, and thrombin generation assays - a review of the literature.

Journal of Thrombosis and Haemostasis, 2022
Direct oral anticoagulants (DOACs) account for most oral anticoagulant use. DOAC-associated bleeding events are commonly encountered in clinical practice and are associated with substantial morbidity and mortality.
Joseph R. Shaw, L. Castellucci, D. Siegal, M. Carrier   +3 more
semanticscholar   +1 more source

Clinical use of thrombin generation assays

Journal of Thrombosis and Haemostasis, 2021
Determining patient's coagulation profile, i.e. detecting a bleeding tendency or the opposite, a thrombotic risk, is crucial for clinicians in many situations.
N. Binder, F. Depasse, J. Mueller, T. Wissel, S. Schwers, M. Germer, Björn Hermes, P. Turecek   +7 more
semanticscholar   +1 more source

Thrombin generation and implications for hemophilia therapies: A narrative review

Research and Practice in Thrombosis and Haemostasis, 2022
Thrombin plays an essential role in achieving and maintaining effective hemostasis and stable clot formation. In people with hemophilia, deficiency of procoagulant factor (F)VIII or FIX results in insufficient thrombin generation, leading to reduced clot
R. Sidonio, M. Hoffman, G. Kenet, Y. Dargaud   +3 more
semanticscholar   +1 more source

Thrombin generation in patients with COVID-19 with and without thromboprophylaxis

Clinical Chemistry and Laboratory Medicine, 2021
Objectives Thrombin generation (TG) with and without thrombomodulin (TM) was evaluated in COVID-19 patients with different disease severity and thromboprophylaxis regimen, in order to understand the prothrombotic profile.
E. Campello, C. Bulato, L. Spiezia, A. Boscolo, Francesco Poletto, M. Cola, S. Gavasso, C. Simion, C. Radu, A. Cattelan, I. Tiberio, R. Vettor, P. Navalesi, P. Simioni   +13 more
semanticscholar   +1 more source

Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy

Frontiers in Cardiovascular Medicine, 2021
Background: Patients using dual antiplatelet therapy after percutaneous coronary intervention are at risk for bleeding. It is currently unknown whether thrombin generation can be used to identify patients receiving dual antiplatelet therapy with ...
C. P. D. M. de Breet, C. P. D. M. de Breet, S. Zwaveling, S. Zwaveling, M. J. A. Vries, R. G. van Oerle, Y. M. C. Henskens, A. W. J. van't Hof, A. W. J. van't Hof, P. E. J. van der Meijden, L. Veenstra, H. ten Cate, H. ten Cate, R. H. Olie, R. H. Olie   +14 more
doaj   +1 more source

Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma

Scientific Reports, 2023
Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo, Claus V. B. Hviid, Ole Brink, Svend Juul, Lars C. Borris, Anne-Mette Hvas   +5 more
doaj   +1 more source

Automated Thrombin Generation Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements [PDF]

, 2021
Background: The thrombin generation assay (TG) is a promising approach to measure the degree of anticoagulation in patients treated with direct oral anticoagulants (DOAC).
Gerber, B., Cédric Bovet, Mendez, Adriana, Mendez, A., Walter A. Wuillemin, Adriana Mendez, Wuillemin, W.A., Studt, J.D., Michael Nagler, Studt, Jan-Dirk, Alberio, Lorenzo, Alberio, L., Schmidt, Adrian, Tamana Meihandoest, Maeder, G.M., Lorenzo Alberio, Bovet, C., Adrian Schmidt, Meihandoest, T., Maeder, Gabriela Monika, Schmidt, A., Nagler, M., Meihandoest, Tamana, Pierre Fontana, Graf, Lukas, Lukas Graf, Gerber, Bernhard, Bernhard Gerber, Sauter, Thomas C, Thomas C. Sauter, Graf, L., Jan-Dirk Studt, Gabriela Monika Maeder, Fontana, P., Nagler, Michael, Sauter, T.C., Fontana, Pierre, Bovet, Cédric, Wuillemin, Walter A   +38 more
core   +1 more source

Editorial: Advances in thrombin generation

Frontiers in Cardiovascular Medicine, 2023
Romy de Laat-Kremers, Stéphane Zuily, Bas de Laat, Bas de Laat   +3 more
doaj   +3 more sources

From principle to practice: bridging the gap in patient profiling. [PDF]

PLoS ONE, 2013
The standard clinical coagulation assays, activated partial thromboplastin time (aPTT) and prothrombin time (PT) cannot predict thrombotic or bleeding risk.
Jonathan H Foley, Thomas Orfeo, Anetta Undas, Kelley C McLean, Ira M Bernstein, Georges-Etienne Rivard, Kenneth G Mann, Stephen J Everse, Kathleen E Brummel-Ziedins   +8 more
doaj   +1 more source

Usefulness of Thrombin Generation [PDF]

Hämostaseologie, 2020
AbstractThrombin generation (TG) is a global coagulation procedure meant to continuously monitor thrombin formation and decay upon exposure of platelet-poor plasma to exogenous triggers such as tissue factor, phospholipids, and calcium chloride. The procedure can also be performed in platelet-rich plasma by omitting exogenous phospholipids.
openaire   +2 more sources