Results 21 to 30 of about 97,937 (350)

rFVIIIa-platelet binding enhances platelet procoagulant activity independently of thrombin generation. [PDF]

Blood Vessel Thromb Hemost
Strebel A, Lickert S, Klamroth R, Vogel V, Pennacchio FA.   +4 more
europepmc   +3 more sources

Coagulation factors and the protein C system as determinants of thrombin generation in a normal population [PDF]

Journal of Thrombosis and Haemostasis, 2008
Arne W. J. H. Dielis, Elisabetta Castoldi, Henri M.H. Spronk, René van Oerle, Karly Hamulyák, Hugo Ten Cate, Jan Rosing   +6 more
openalex   +3 more sources

Thrombin Generation as a Method to Identify the Risk of Bleeding in High Clinical-Risk Patients Using Dual Antiplatelet Therapy

Frontiers in Cardiovascular Medicine, 2021
Background: Patients using dual antiplatelet therapy after percutaneous coronary intervention are at risk for bleeding. It is currently unknown whether thrombin generation can be used to identify patients receiving dual antiplatelet therapy with ...
C. P. D. M. de Breet, C. P. D. M. de Breet, S. Zwaveling, S. Zwaveling, M. J. A. Vries, R. G. van Oerle, Y. M. C. Henskens, A. W. J. van't Hof, A. W. J. van't Hof, P. E. J. van der Meijden, L. Veenstra, H. ten Cate, H. ten Cate, R. H. Olie, R. H. Olie   +14 more
doaj   +1 more source

Age-dependent thrombin generation predicts 30-day mortality and symptomatic thromboembolism after multiple trauma

Scientific Reports, 2023
Trauma-induced coagulopathy (TIC) is a risk factor for death and is associated with deviations in thrombin generation. TIC prevalence and thrombin levels increase with age.
Maj Lesbo, Claus V. B. Hviid, Ole Brink, Svend Juul, Lars C. Borris, Anne-Mette Hvas   +5 more
doaj   +1 more source

From principle to practice: bridging the gap in patient profiling. [PDF]

PLoS ONE, 2013
The standard clinical coagulation assays, activated partial thromboplastin time (aPTT) and prothrombin time (PT) cannot predict thrombotic or bleeding risk.
Jonathan H Foley, Thomas Orfeo, Anetta Undas, Kelley C McLean, Ira M Bernstein, Georges-Etienne Rivard, Kenneth G Mann, Stephen J Everse, Kathleen E Brummel-Ziedins   +8 more
doaj   +1 more source

Genetic Determinants of Thrombin Generation and Their Relation to Venous Thrombosis: Results from the GAIT-2 Project. [PDF]

PLoS ONE, 2016
BACKGROUND:Venous thromboembolism (VTE) is a common disease where known genetic risk factors explain only a small portion of the genetic variance. Then, the analysis of intermediate phenotypes, such as thrombin generation assay, can be used to identify ...
Laura Martin-Fernandez, Andrey Ziyatdinov, Marina Carrasco, Juan Antonio Millon, Angel Martinez-Perez, Noelia Vilalta, Helena Brunel, Montserrat Font, Anders Hamsten, Juan Carlos Souto, José Manuel Soria   +10 more
doaj   +1 more source

Thrombin generation in the Glasgow Myocardial Infarction Study. [PDF]

PLoS ONE, 2013
BACKGROUND: Thrombin is a key protease in coagulation also implicated in complex pathology including atherosclerosis. To address the role of thrombin in relation to myocardial infarction (MI) we explored thrombin generation analysis in plasma from ...
Machiel Smid, Arne W J H Dielis, Henri M H Spronk, Ann Rumley, Rene van Oerle, Mark Woodward, Hugo ten Cate, Gordon Lowe   +7 more
doaj   +1 more source

Usefulness of Thrombin Generation [PDF]

Hämostaseologie, 2020
AbstractThrombin generation (TG) is a global coagulation procedure meant to continuously monitor thrombin formation and decay upon exposure of platelet-poor plasma to exogenous triggers such as tissue factor, phospholipids, and calcium chloride. The procedure can also be performed in platelet-rich plasma by omitting exogenous phospholipids.
openaire   +2 more sources

Evaluation of the hemostatic potential at coronary artery bypass surgery during long-term aspirin therapy [PDF]

Терапевтический архив, 2016
Aim. To estimate thrombin generation test parameters in patients with coronary heart disease during coronary artery bypass surgery under extracorporeal circulation after transfusion of donor platelet concentrates during long-term therapy with ...
O V Gruzdeva, E V Fanaskova, O E Akbasheva, E G Uchasova, T Yu Penskaya, G P Plotnikov, Yu A Dyleva, K E Krivoshapova, O L Barbarash   +8 more
doaj   +1 more source

Defining the boundaries of normal thrombin generation: investigations into hemostasis. [PDF]

PLoS ONE, 2012
In terms of its soluble precursors, the coagulation proteome varies quantitatively among apparently healthy individuals. The significance of this variability remains obscure, in part because it is the backdrop against which the hemostatic consequences of
Christopher M Danforth, Thomas Orfeo, Stephen J Everse, Kenneth G Mann, Kathleen E Brummel-Ziedins   +4 more
doaj   +1 more source