Results 41 to 50 of about 3,896,793 (331)
Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis. [PDF]
PLoS ONE, 2016 Circulating microparticles (MPs) derived from endothelial cells and blood cells bear procoagulant activity and promote thrombin generation. Thrombin exerts proinflammatory effects mediating the progression of atherosclerosis.
Patrick Horn +8 more
doaj +1 more source
Prognostic value of thrombin generation parameters in hospitalized COVID-19 patients
Scientific Reports, 2020 SARS-CoV-2 infection increases the risk of thrombosis by different mechanisms not fully characterized. Although still debated, an increase in D-dimer has been proposed as a first-line hemostasis test associated with thromboembolic risk and unfavorable ...
M. E. de la Morena-Barrio +10 more
semanticscholar +1 more source
Haematologica, 2008 Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis +6 more
doaj +1 more source
Syncytiotrophoblast microvesicles released from pre-eclampsia placentae exhibit increased tissue factor activity. [PDF]
PLoS ONE, 2011 Pre-eclampsia is a complication of pregnancy associated with activation of coagulation. It is caused by the placenta, which sheds increased amounts of syncytiotrophoblast microvesicles (STBM) into the maternal circulation. We hypothesized that STBM could
Chris Gardiner +5 more
doaj +1 more source
The in vitro addition of idarucizumab to plasma samples from patients increases thrombin generation
Scientific Reports, 2021 Dabigatran interferes with many coagulation tests. To overcome this obstacle the use of idarucizumab as an in vitro antidote to dabigatran has been proposed.
Mojca Božič Mijovski +4 more
doaj +1 more source
Anesthesia and Analgesia, 2020 BACKGROUND: Coagulopathy and hemostatic abnormalities remain a challenge in patients following trauma and major surgery. Coagulopathy in this setting has a multifactorial nature due to tissue injury, hemodilution, hypothermia, and acidosis, the severity ...
A. Mitrophanov +4 more
semanticscholar +1 more source
Scientific Reports, 2023 Baboon models are often used to investigate haemostatic diseases, such as acquired thrombotic thrombocytopenic purpura or bacterial sepsis-induced disseminated intravascular coagulation, and their potential treatment with novel drugs. Thrombin generation
J. Joubert +2 more
doaj +1 more source
The Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation [PDF]
, 2017 The aim of this study was to investigate the effect of the serine/threonine protein phosphatase inhibitor, calyculin-A (CLA), on clot formation and on the procoagulant activity of human platelets. Platelet-rich plasma (PRP) samples were preincubated with
Clemetson, Kenneth John +15 more
core +1 more source
Follow-up of thrombin generation after prostate cancer surgery: global test for increased hypercoagulability. [PDF]
PLoS ONE, 2012 Recent studies provided evidence that evaluation of thrombin generation identifies patients at thrombotic risk. Thrombin generation has a central role in hemorrhage control and vascular occlusion and its measurement provides new metrics of these ...
Matyas Benyo +6 more
doaj +1 more source
Thrombin generation and bleeding in haemophilia A [PDF]
Haemophilia, 2009 Summary. Haemophilia A displays phenotypic heterogeneity with respect to clinical severity. The aim of this study was to determine if tissue factor (TF)‐initiated thrombin generation profiles in whole blood in the presence of corn trypsin inhibitor (CTI) are predictive of bleeding risk in haemophilia A. We studied factor(F) VIII deficient individuals (
K E, Brummel-Ziedins +4 more
openaire +2 more sources