Results 51 to 60 of about 2,633,554 (103)

Towards a standardization of thrombin generation assessment: The influence of tissue factor, platelets and phospholipids concentration on the normal values of Thrombogram-Thrombinoscope assay

Thrombosis Journal, 2005
Background Thrombin generation assay was developed several years ago to mimic physiological coagulation mechanisms but it had important limitations. Thrombogram-Thrombinoscope assay using a fluorogenic substrate, allows obtaining thrombin generation ...
Leflem Lena, Busson Joël, Depasse François, Gerotziafas Grigoris T, Elalamy Ismail, Samama Meyer M   +5 more
doaj   +1 more source

Antibody Mediated Rejection (ABMR) after Kidney Transplantation: Diagnostic and Prognostic Markers of Hemostasis and Endothelial Cell Damage

, 2023
The study investigated the effects of de novo anti-HLA donor-specific antibodies (DSAs) on kidney transplant recipients. Twenty-one patients with DSAs and nineteen without were observed, aiming to understand how DSAs might cause endothelial damage and ...
Baah, Mary
core  

Thrombin Generation by Gentamicin

, 2014
The present work examines how human coagulation is influenced by gentamicin (gentamicin×H2SO4), an often used aminoglycoside antibiotic in clinical practice.
Albert, Dada Aishe, Stief, T. (Prof. Dr.)   +1 more
core   +1 more source

Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography

Platelets, 2018
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot, Clémence Docq, Denis Wahl, Patrick Lacolley, Véronique Regnault, Jérémy Lagrange   +5 more
doaj   +1 more source

9.5 COAGULATION CONTROL BY THE RHOA PATHWAY AND THE EXCHANGE FACTOR ARHGEF1

Artery Research, 2016
Platelet activation by thrombin is an auto-amplification loop of thrombin generation, a major factor in the formation of atherosclerotic plaques. The small G protein RhoA, under the direct control of the exchange factor Arhgef1, modulates several ...
Camille Rouillon, Amel Mohammadi, Gervaise Loirand, Veronique Regnault, Patrick Lacolley   +4 more
doaj   +1 more source

Coagulation challenges in pregnancy: from thrombophilia involvement and management to the utility of thrombin generation monitoring

Clinical and Experimental Obstetrics & Gynecology, 2020
Despite numerous studies, there is no general agreement on an ideal biomarker for estimating thrombotic risk in pregnant women. However, it is accepted that the analysis of thrombin generation assesses the coagulation state more accurately compared to ...
R. Mihăilă
doaj   +1 more source

Thrombin generation and venous thromboembolism

, 2008
SummaryVenous thromboembolism is a chronic and potential fatal disease. Determination of recurrence risk is time-consuming and costly, and sometimes not feasible: many patients carry more than one risk factor, the relevance of some factors with regard to
S. Eichinger
core   +1 more source

Comparison of Effects of Anti-thrombin Aptamers HD1 and HD22 on Aggregation of Human Platelets, Thrombin Generation, Fibrin Formation, and Thrombus Formation Under Flow Conditions

Frontiers in Pharmacology, 2019
HD1 and HD22 are two of the most-studied aptamers binding to thrombin exosite I and exosite, respectively. To complete of their pharmacological profiles, the effects of HD1 and HD22 on thrombin-, ristocetin-, and collagen-induced human platelet ...
Katarzyna Derszniak, Katarzyna Derszniak, Kamil Przyborowski, Karolina Matyjaszczyk, Karolina Matyjaszczyk, Martijn Moorlag, Martijn Moorlag, Bas de Laat, Bas de Laat, Maria Nowakowska, Stefan Chlopicki, Stefan Chlopicki   +11 more
doaj   +1 more source

Thrombin generation assay in COVID-19 patients shows a hypocoagulable pattern

Bleeding, Thrombosis and Vascular Biology
Patients with COVID-19 often exhibit coagulopathy, which can significantly impact prognosis. Therefore, investigating coagulation in this context is clinically relevant.
Giovanni L. Tiscia, Donatella Colaizzo, Antonio De Laurenzo, Filomena Cappucci, Lucia Fischetti, Elena Chinni, Mario Mastroianno, Giovanni Favuzzi, Massimo Carella, Elvira Grandone   +9 more
doaj   +1 more source

Increased Clot Formation in the Absence of Increased Thrombin Generation in Patients with Peripheral Arterial Disease: A Case–Control Study

Frontiers in Cardiovascular Medicine, 2017
BackgroundIn peripheral arterial disease (PAD), activation of the hemostatic system may contribute to atherosclerosis progression and atherothrombotic events.ObjectiveThis case–control study assesses the overall coagulation status in PAD patients by ...
Marie-Claire F. Kleinegris, Joke Konings, Joke Konings, Jan W. Daemen, Yvonne Henskens, Bas de Laat, Bas de Laat, Henri M. H. Spronk, Arina J. ten Cate-Hoek, Hugo ten Cate   +9 more
doaj   +1 more source