Results 51 to 60 of about 3,896,793 (331)

Thrombin generation capacity is enhanced by low antithrombin activity and depends on the activity of the related coagulation factors

Thrombosis Journal, 2022
Background Supplementation with antithrombin (AT) concentrates is now common in the treatment of congenital and acquired AT deficiency. However, there is no established consensus on the target and timing of supplementation.
Takumi Tsuchida, Mineji Hayakawa, Shota Kawahara, Osamu Kumano   +3 more
doaj   +1 more source

Effects of platelets activated by different agonists on fibrin formation and thrombin generation

Platelets, 2023
Activated platelets possess procoagulant activity expressing on their surface phosphatidylserine (PS), a substrate for assembling coagulation complexes. We examined the effects of platelets activated by different agonists on fibrin formation and thrombin
Ivan A. Muravlev, Anatoly B. Dobrovolsky, Olga A. Antonova, Svetlana G. Khaspekova, Alexey V. Mazurov   +4 more
doaj   +1 more source

Thrombin generation in a woman with heterozygous factor V Leiden and combined oral contraceptives: A case report

Research and Practice in Thrombosis and Haemostasis, 2020
Combined oral contraceptives and factor V Leiden mutation are multiplicative risk factors for venous thromboembolism. However, it remains unknown whether this multiplicative effect is reflected in thrombin generation assays.
Maxime G. Zermatten, Debora Bertaggia Calderara, Alessandro Aliotta, Lorenzo Alberio   +3 more
doaj   +1 more source

Thrombin-generating capacity in patients with von Willebrand’s disease

Haematologica, 2007
Background and Objectives on Willebrand’s disease (VWD) is the most common hereditary bleeding disorder. Its severity can be classified on the basis of von Willebrand factor (VWF) and factor VIII (FVIII) plasma levels and according to the clinical ...
Lucia Rugeri, Suzette Beguin, Coenraad Hemker, Jean-Claude Bordet, Raphael Fleury, Brigitte Chatard, Claude Negrier, Yesim Dargaud   +7 more
doaj   +1 more source

DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and ...
Rahul Kumar, Vijay K. Sonkar, Jagadish Swamy, Azaj Ahmed, Anjali A. Sharathkumar, Gary L. Pierce, Sanjana Dayal   +6 more
doaj   +1 more source

Exploring the utility of a novel point‐of‐care whole blood thrombin generation assay following trauma: A pilot study

Research and Practice in Thrombosis and Haemostasis, 2021
Introduction Plasma thrombin generation kinetics as measured by the calibrated automated thrombogram (CAT) assay is a predictor of symptomatic venous thromboembolism after trauma.
Michael J. Ferrara, Taleen A. MacArthur, Saulius Butenas, Kenneth G. Mann, Joseph M. Immermann, Grant M. Spears, Kent R. Bailey, Rosemary A. Kozar, Stephanie F. Heller, Erica A. Loomis, Daniel Stephens, Myung S. Park   +11 more
doaj   +1 more source

Overview of thrombin generation parameters.

, 2022
Overview of thrombin generation parameters.
Astrid van Hylckama Vlieg (335532), Carolina E. Touw (12152623), Ype de Jong (602387)   +2 more
core   +1 more source

Factor Xa generation by computational modeling: an additional discriminator to thrombin generation evaluation. [PDF]

PLoS ONE, 2012
Factor (f)Xa is a critical enzyme in blood coagulation that is responsible for the initiation and propagation of thrombin generation. Previously we have shown that analysis of computationally generated thrombin profiles is a tool to investigate ...
Kathleen E Brummel-Ziedins, Thomas Orfeo, Matthew Gissel, Kenneth G Mann, Frits R Rosendaal   +4 more
doaj   +1 more source

Neutrophil extracellular trap-microparticle complexes enhance thrombin generation via the intrinsic pathway of coagulation in mice

Scientific Reports, 2018
Abdominal sepsis is associated with dysfunctional hemostasis. Thrombin generation (TG) is a rate-limiting step in systemic coagulation. Neutrophils can expell neutrophil extracellular traps (NETs) and/or microparticles (MPs) although their role in ...
Yongzhi Wang, Lingtao Luo, O. Braun, Johan O. Westman, Raed Madhi, H. Herwald, M. Mörgelin, H. Thorlacius   +7 more
semanticscholar   +1 more source

Mathematical modeling identifies clotting factor combinations that modify thrombin generation in normal and factor VIII-, IX-, or XI-deficient blood

Research and Practice in Thrombosis and Haemostasis
Background: In healthy individuals, plasma levels of clotting proteins naturally vary within a range of 50% to 150% of their mean values. We do not know how these variations modify thrombin generation.
Michael T. Stobb, Keith B. Neeves, Dougald M. Monroe, Suzanne S. Sindi, Karin Leiderman, Aaron L. Fogelson   +5 more
doaj   +1 more source