Results 71 to 80 of about 2,633,554 (103)

Enhanced thrombin generation after cardiopulmonary bypass surgery.

, 2011
Thrombin generation has a key role in the pathophysiology of hemostasis. Research has focused on the intraoperative course of hemostasis, while little is known about postoperative hemostatic activation.
Lison, S;Dietrich, W;Braun, S;Boehm, J;Schuster, T;Englhard, A;Perchuc, A;Spannagl, M;Busley, R
core   +1 more source

Assessment of thrombin generation

, 2010
Thrombin plays a central role in haemostasis through both procoagulant and anticoagulant functions. Although measurement of thrombin generation in the laboratory has been possible for many years, recent advances in understanding a wider scope of ...
Adams, MJ (15509435)
core  

Increased thrombin generation after acute versus chronic coronary disease as assessed by the thrombin generation test [PDF]

, 2008
Atherosclerosis is the most common pathophysiologic substrate of coronary artery disease (CAD). Whereas plaque progression and arterial remodeling are critical components in chronic CAD, intracoronary thrombosis over plaque disruption is causally related
Zudaire, M. (Maite), Rodriguez, J.A. (José Antonio), Orbe, J. (Josune), Serrano, R. (Rosario), Martinez-de-Lizarrondo, S. (Sara), Coma-Canella, I. (Isabel), Paramo, J.A. (José Antonio)   +6 more
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Improvements in the Thrombin Generation Test

, 1960
SummaryThe influence of glass contact on the thrombin generation test was demonstrated and a modified method described.Nearly all prothrombin had been converted to thrombin before the thrombin concentration reached its maximum.
Preben Ollendorff
core   +1 more source

Thrombin-thrombomodulin interaction: energetics and potential role of water as an allosteric effector.

, 1995
The interaction of rabbit lung thrombomodulin (TM) and C-terminal hirudin 54-65 fragment (Hir54-65) with human alpha-thrombin were investigated by exploiting their competitive inhibition of thrombin-fibrinogen interaction.
De Cristofaro, Raimondo, De Candia, Erica, Landolfi, Raffaele, Rocca, Bianca   +3 more
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Comparing factor Xa and thrombin generation.

, 2013
Thrombin generation profiles from the same population, previously determined using the same methodology [15], are compared to their fXa profiles. Three pairs of overlapping individual thrombin generation profiles are shown on the left.
Frits R. Rosendaal (335481), Thomas Orfeo (135845), Kenneth G. Mann (135848), Matthew Gissel (135847), Kathleen E. Brummel-Ziedins (135844)   +4 more
core   +1 more source

Modeling the role of platelet-released polyphosphates in tissue factor-initiated coagulation under flow

Research and Practice in Thrombosis and Haemostasis
Background: Activated platelets release polyphosphate (polyP), a linear polymer of inorganic phosphate residues, from dense granules. Experiments performed under no-flow conditions show that polyP alters the kinetics of tissue factor (TF) pathway ...
Sradha Ramesh Bhatt, Alexander G. Ginsberg, Stephanie A. Smith, James H. Morrissey, Aaron L. Fogelson   +4 more
doaj   +1 more source

The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity

, 2000
The role of the platelet glycoprotein (GP) Ib-V-IX receptor in thrombin activation of platelets has remained controversial although good evidence suggests that blocking this receptor affects platelet responses to this agonist. The mechanism of expression
Dörmann, D, Kehrel, BE, Clemetson, KJ
core  

Assessment of Thrombin Generation: Useful or Hype?

, 2009
Thrombin plays an important role in hemostasis through its multiple functions across blood coagulation, platelet activation, and fibrinolysis. The measurement of thrombin generation is therefore viewed as a potentially useful test that could be applied ...
Adams, MJ (15509435)
core   +1 more source

Editorial: Advances in thrombin generation

Frontiers in Cardiovascular Medicine, 2023
Romy de Laat-Kremers, Stéphane Zuily, Bas de Laat, Bas de Laat   +3 more
doaj   +1 more source