Results 81 to 90 of about 3,896,793 (331)

Inhibition of thrombin generation 12 hours after intake of direct oral anticoagulants

Research and Practice in Thrombosis and Haemostasis, 2020
Background The residual antithrombotic activity 12 hours after intake of direct oral anticoagulants (DOACs) is of clinical relevance in the setting of bleeding or urgent surgery.
Michael Metze, Christian Pfrepper, Tristan Klöter, Stephan Stöbe, Roland Siegemund, Thomas Siegemund, Elvira Edel, Ulrich Laufs, Sirak Petros   +8 more
doaj   +1 more source

Concizumab, an anti‐tissue factor pathway inhibitor antibody, induces increased thrombin generation in plasma from haemophilia patients and healthy subjects measured by the thrombin generation assay

Haemophilia, 2017
Concizumab, a humanized monoclonal antibody against tissue factor pathway inhibitor (TFPI), is being developed as a subcutaneously (s.c.) administered treatment for haemophilia.
E. Waters, J. Sigh, U. Friedrich, I. Hilden, B. Sørensen   +4 more
semanticscholar   +1 more source

Thrombin generation on coated discs.

, 2015
Thrombin generation for discs coated with either ApoA-I-, ApoB-, Isotype- or no antibody (empty discs), compared to thrombin generation in absence of a disc (negative control). (n = 4).
Leo H. Koole (538507), Aart C. Strang (714400), Allard C. van der Wal (33616), Paul P. Tak (23064), Erik S. G. Stroes (213339), Joris I. Rotmans (530517), Robbert J. de Winter (372354), Carlie J. M. de Vries (631854), Menno L. W. Knetsch (714401), Radjesh J. Bisoendial (714402)   +9 more
core   +1 more source

Mechanically Spatio‐Chimeric Fibrin Assembly Enables Vascular‐Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair

Advanced Materials, EarlyView.
SPARC (spatio‐chimeric, plasma‐based, anisotropic, and shear‐responsive construct) that integrates myogenic and vascular microenvironments within a single construct. The dual‐modulus matrix directs aligned myotube formation and endothelial network development, enabling a vascularized muscle implant that seamlessly anastomoses with host tissue and ...
Su Hyun Jung, Minjun Kim, Da‐Yoon Kim, Min Kyu Kim, Sieun Lee, Yoonhee Jin, Joo H. Kang   +6 more
wiley   +1 more source

Antibody Mediated Rejection (ABMR) after Kidney Transplantation: Diagnostic and Prognostic Markers of Hemostasis and Endothelial Cell Damage

, 2023
The study investigated the effects of de novo anti-HLA donor-specific antibodies (DSAs) on kidney transplant recipients. Twenty-one patients with DSAs and nineteen without were observed, aiming to understand how DSAs might cause endothelial damage and ...
Baah, Mary
core  

Semi-automated thrombin dynamics applying the ST Genesia thrombin generation assay

Frontiers in Cardiovascular Medicine, 2022
BackgroundThe haemostatic balance is an equilibrium of pro- and anticoagulant factors that work synergistically to prevent bleeding and thrombosis.
Audrey Carlo, Qiuting Yan, Qiuting Yan, Hugo Ten Cate, Romy De Laat-Kremers, Romy De Laat-Kremers, Bas De Laat, Bas De Laat, Marisa Ninivaggi   +8 more
doaj   +1 more source

Hydrogel‐Based Airway‐on‐Tube With Perfusable Endothelial Lumen and Outward Epithelialization

Advanced Materials, EarlyView.
A hydrogel‐based airway‐on‐tube platform featuring a perfusable endothelial lumen and outward epithelialization is presented. The system supports primary human bronchial epithelial and lung microvascular endothelial coculture under air‐liquid interface conditions.
Ali Doryab, Jack F. Murphy, Michael Bartolf‐Kopp, Jenny C‐C Hsin, Alice Chernaik, Frank McCaughan, Yan Yan Shery Huang, Tomasz Jungst, Jürgen Groll   +8 more
wiley   +1 more source

Protein disulfide isomerase enhances tissue factor-dependent thrombin generation

Biochemical and Biophysical Research Communications - BBRC, 2018
Protein disulfide isomerase (PDI) plays an important role in fibrin generation in vivo, but the underlying mechanism remains largely unknown. In this study, using thrombin generation assay (TGA), we investigated whether PDI contributes to tissue factor ...
Fengwu Chen, Zhenzhen Zhao, Junsong Zhou, Yi Lu, D. Essex, Yi Wu   +5 more
semanticscholar   +1 more source

Thrombin Generation by Gentamicin

, 2014
The present work examines how human coagulation is influenced by gentamicin (gentamicin×H2SO4), an often used aminoglycoside antibiotic in clinical practice.
Albert, Dada Aishe, Stief, T. (Prof. Dr.)   +1 more
core   +1 more source

Bubble Formation Control: Fabrication of Centimeter‐Sized Tissue‐Like Constructs by Catalase‐Coated Oxygen‐Releasing Hydrogel

Advanced Materials, EarlyView.
Oxygen‐releasing hydrogels are widely used to support cell survival in 3D cultures and to promote wound healing. However, incorporating catalase to convert H2O2 into O2 often generates additional oxygen bubbles, leading to material instability which rarely addressed.
Sukulya Bunuasunthon, Isabel F. Amaral, Ana P. Pêgo, Michiya Matsusaki   +3 more
wiley   +1 more source