Results 101 to 110 of about 3,896,793 (331)

Thrombin generation assays: accruing clinical relevance [PDF]

Current Opinion in Hematology, 2004
After decades of near oblivion, thrombin generation is being revived as an overall function test of the plasmatic coagulation system in platelet-poor plasma (PPP). In platelet-rich plasma (PRP) it assesses platelet procoagulant functions as well.The recently developed use of special fluorogenic thrombin substrates allows monitoring of thrombin ...
Hemker, H. Coenraad, Al Dieri, Raed, Beguin, Suzette   +2 more
openaire   +3 more sources

Monitoring platelet dependent thrombin generation in mice

, 2010
Calibrated automated thrombin generation assay was adapted to measure thrombin generation in platelet rich plasma from mice. Vena cava phlebotomy appeared the best technique for blood sampling.
Hemker, H. Coenraad, Henri M.H. Spronk, Yesim Dargaud, Dargaud, Yesim, Ten Cate, Hugo, Peter Leenders, Hugo Ten Cate, Leenders, Peter, H. Coenraad Hemker, Spronk, Henri M. H.   +9 more
core   +1 more source

Liquid Metal Nanotransformers for Drug‐Resistant Pan‐Cancer Therapy in Patient‐Derived Organoids

Advanced Science, EarlyView.
Pan‐cancer therapies are severely limited in drug‐resistance patients due to genetic mutations and other factors, resulting in poor therapeutic outcomes and constrained clinical benefit. Liquid metal nanotransformers, a new class of shape‐transformable nanomaterials capable of dramatic morphological changes, offer a promising physical strategy to ...
Xiaojie Yuan, Xuelin Wang, Zhongyao Chen, Shuo Wang, Weining Gao, Ziyi Chen, Runyang Li, Cheng Hao, Lei Zhang, Qiongqiong Zhang, Ke Zhang, Mei Yu, Qian Liu, Jingxuan Wang, Huiping Li, Simpkins Fiona, Jing Liu, Qiang Liu, Peng Liu, Yawei Hu   +19 more
wiley   +1 more source

Platelet aggregation impacts thrombin generation assessed by calibrated automated thrombography

Platelets, 2018
A calibrated automated thrombogram (CAT) is performed usually with human platelet-free plasma (PFP) but may be more relevant with platelet-rich plasma (PRP). In this case, platelets are not stimulated by subendothelial molecules like collagen.
Mélusine Didelot, Clémence Docq, Denis Wahl, Patrick Lacolley, Véronique Regnault, Jérémy Lagrange   +5 more
doaj   +1 more source

Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2016
Thrombin is a key enzyme in hemostasis and thrombosis, regulating pro‐ and anticoagulant reactions by interacting with other coagulation proteins and cellular receptors.[1][1] Thrombin also carries out a plethora of biologically relevant actions that ...
H. ten Cate, H. Hemker
semanticscholar   +1 more source

The clinical utility of thrombin generation

, 2011
PhDThe Calibrated Automated Thrombogram (CAT) thrombin generation assay is a technique that allows the characterisation of an individual’s capacity to produce thrombin in response to a procoagulant stimulus. As such it is a global screening test for both
Bevan, Shaun Patrick
core  

Bench‐to‐Bedside Translation of Self‐Healing Colloidal Hydrogels as Next Generation Design of Flowable Hemostatic Matrix: From Preclinical Evaluation to Human Clinical Trials

Advanced Science, EarlyView.
ABSTRACT Self‐healing materials represent a paradigm shift in designing functional biomedical devices for drug delivery, tissue regeneration, and 3D bioprinting. However, their clinical translation remains limited by challenges such as insufficient mechanical strength, potential cytotoxicity from chemical modifications, and complex activation ...
Ganjun Feng, Kaiwen Chen, Qiwei Ying, Shuya Wang, Xin Li, Guanlin Li, Yantao Zhao, Binghua Ma, Huanan Wang, Dawei Li, Lijun Zhang, Jian Zhang, Yu Zhao, Changle Ren, Baodong Chen, Yueming Song   +15 more
wiley   +1 more source

Mathematical models of thrombin generation [PDF]

, 2023
Thrombin generation is a key step in the formation of a blood clot. It is the only enzyme able to cleave the protein fibrinogen into fibrin, which is vital to both the structure and stability of a clot.
Owen, Matt J
core   +1 more source

Dynamics of Thrombin Generation and Flux from Clots during Whole Human Blood Flow over Collagen/Tissue Factor Surfaces*

Journal of Biological Chemistry, 2016
Coagulation kinetics are well established for purified blood proteases or human plasma clotting isotropically. However, less is known about thrombin generation kinetics and transport within blood clots formed under hemodynamic flow.
Shu Zhu, Yichen Lu, T. Sinno, S. Diamond
semanticscholar   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source