Results 121 to 130 of about 3,896,793 (331)

9.5 COAGULATION CONTROL BY THE RHOA PATHWAY AND THE EXCHANGE FACTOR ARHGEF1

Artery Research, 2016
Platelet activation by thrombin is an auto-amplification loop of thrombin generation, a major factor in the formation of atherosclerotic plaques. The small G protein RhoA, under the direct control of the exchange factor Arhgef1, modulates several ...
Camille Rouillon, Amel Mohammadi, Gervaise Loirand, Veronique Regnault, Patrick Lacolley   +4 more
doaj   +1 more source

Dabigatran is Less Effective Than Warfarin at Attenuating Mechanical Heart Valve-Induced Thrombin Generation

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2015
Background Patients with mechanical heart valves (MHV) require warfarin to prevent thromboembolism. Although dabigatran was as effective as warfarin for stroke prevention in atrial fibrillation when compared with warfarin in patients with MHV, the study ...
I. Jaffer, A. Stafford, J. Fredenburgh, R. Whitlock, N. Chan, J. Weitz   +5 more
semanticscholar   +1 more source

Thrombin generation after cariopulmonary bypass

, 2010
Thrombin ist das Schlüsselenzym der Gerinnung. Prothrombotische Komplikationen wie Schlaganfälle und Herzinfarkte, sind nach Herzoperationen häufig.
Englhard, Anna Sophie
core  

Enhanced thrombin generation after cardiopulmonary bypass surgery.

, 2011
Thrombin generation has a key role in the pathophysiology of hemostasis. Research has focused on the intraoperative course of hemostasis, while little is known about postoperative hemostatic activation.
Lison, S;Dietrich, W;Braun, S;Boehm, J;Schuster, T;Englhard, A;Perchuc, A;Spannagl, M;Busley, R
core   +1 more source

Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils

Advanced Science, EarlyView.
We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr, Anne Schmitz, Meshkat Dinarvand, Franziska Wulfert, Sangeetha Shankar, Bjoern F. Hill, Michael Wojak, Juliana Gretz, Marie Britz, Elsa Neubert, Magdalena Shumanska, Sofia Kaushik, Linda Kartaschew, Ivan Bogeski, James Daniel, Sebastian Jung, Johannes Eble, Guido Wabnitz, Luise Erpenbeck, Sebastian Kruss   +19 more
wiley   +1 more source

Monitoring Low Molecular Weight Heparins at Therapeutic Levels: Dose-Responses of, and Correlations and Differences between aPTT, Anti-Factor Xa and Thrombin Generation Assays

PLoS ONE, 2015
Background Low molecular weight heparins (LMWH’s) are used to prevent and treat thrombosis. Tests for monitoring LMWH’s include anti-factor Xa (anti-FXa), activated partial thromboplastin time (aPTT) and thrombin generation.
Owain D Thomas, Emanuel Lybeck, K. Strandberg, N. Tynngård, U. Schött   +4 more
semanticscholar   +1 more source

Lyophilized Synthetic Platelets: In Vitro Characterization and in Vivo Evaluation in Mouse Thrombocytopenia Model

Advanced Science, EarlyView.
ABSTRACT Platelet transfusions to treat bleeding complications use donor‐derived platelets stored at room‐temperature, that have a shelf‐life of only 5–7 days due to bacterial contamination risks. Cold‐stored and freeze‐dried platelets are being investigated for extending shelf‐life, but these still have the inherent challenge of donor‐dependency.
Ujjal Didar Singh Sekhon, Dante Disharoon, Shrijal S. Desai, Baylee Traylor, Emily Gahagan, Emma Quill, Kristin Aldridge, Norman F. Luc, Sonali Rohiwal, Shruti Raghunathan, Rebecca Ahn, Sana Syed, Alexander Dornback, Bipin Chakravarthy Paruchuri, Andrew Ditto, Susan M. Shea, Philip C. Spinella, Matthew D. Neal, Michael A. Bruckman, Christa L. Pawlowski, Anirban Sen Gupta   +20 more
wiley   +1 more source

Anticoagulants and the Propagation Phase of Thrombin Generation

PLoS ONE, 2011
The view that clot time-based assays do not provide a sufficient assessment of an individual's hemostatic competence, especially in the context of anticoagulant therapy, has provoked a search for new metrics, with significant focus directed at techniques that define the propagation phase of thrombin generation.
Orfeo, Thomas, Gissel, Matthew, Butenas, Saulius, Undas, Anetta, Brummel-Ziedins, Kathleen E., Mann, Kenneth G.   +5 more
openaire   +5 more sources

Multidimensional and Multifunctional Laser‐Induced Graphene (LIG) for Point‐of‐Care and Wearable Biosensing, Theranostics, and Bioactive Interfaces Toward Personalized Healthcare and Regenerative Medicine

Advanced Science, EarlyView.
Multidimensional laser‐induced graphene (LIG) spanning from 0D to 3D architectures is comprehensively reviewed for multifunctional biomedical platforms, including biosensing, theranostics, and bioactive interface applications, which highlights its potentials for point‐of‐care diagnostics, wearable health monitoring, smart drug delivery, and tissue ...
Li Zhang, Yurou Yuan, Xiaohong Ding, Wing Cheung Mak   +3 more
wiley   +1 more source

Thrombin generation assay (CAT) v1

, 2017
TG in plasma was measured with the calibrated automated thrombogram (CAT) assay as developed by Hemker and co-workers [18-20]. Briefly, 80 μl platelet poor plasma (PPP) was mixed with 20 μl of a mixture containing tissue factor (Dade-Behring) at a ...
Kurt Van der Speeten, Ming-Hua Zheng, Abraham Marcus, Joris Penders, Seppe Dehaene, Sven Van Poucke, Dana Huskens, Marcus Lancé, Mark Roest, Bart Lauwereins   +9 more
core   +1 more source