Results 51 to 60 of about 279,988 (315)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

FEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara, Kinga Skoczek, Elzbieta Pyza, Milena Damulewicz   +3 more
wiley   +1 more source

Contrast-Enhanced OCT for Damage Detection in Polymeric Resins Embedded with Metallic Nanoparticles via Surface Plasmon Resonance

NDT - Journal of Non-Destructive Testing
Nanoparticle-embedded polymeric materials are an important subject in advanced structural applications due to their advantageous combination of low weight and high mechanical performance.
Maha Hadded, Thiago Luiz Lara Oliveira, Olivier Debono, Emilien Bourdon, Alan Jean-Marie   +4 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Aligning a Synapse [PDF]

Neuron, 2017
Synaptic communication requires alignment of transmitter release sites with transmitter receptors. In this issue of Neuron, Wang et al. (2017) show that α2δ4 subunits link calcium channels to a trans-synaptic complex with glutamate receptors at the visual system's first synapse.
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Automated analysis of neuronal morphology, synapse number and synaptic recruitment

, 2011
peer reviewedThe shape, structure and connectivity of nerve cells are important aspects of neuronal function. Genetic and epigenetic factors that alter neuronal morphology or synaptic localization of pre- and post-synaptic proteins contribute ...
de Bruijn, P., Hjorth, J. J. Johannes, Susanne Eijgenraam, Ooyen, A. van, Hjorth, J.J. Johannes, Bruijn, P. de, Eijgenraam, Susanne, Sabine K. Schmitz, Wouter Veldkamp, van Ooyen, A., Arjen van Ooyen, Veldkamp, W., Hjorth, J.J.J., Christina Georgiou, Joemai, R.M.S., Wijntjes, Rick, van Ooyen, Arjen, Eijgenraam, S., Toonen, R.F.; id_orcid, Verhage, Matthijs, de Jong, A.P.H., Toonen, R.F., Georgiou, C., Jong, A.P.H. de, Veldkamp, W.J.H., Joemai, Raoul M.S., de Jong, Arthur P. H., SCHMITZ, Sabine, Joemai, Raoul M. S., Veldkamp, Wouter, Petra de Bruijn, L. Niels Cornelisse, Ruud F. Toonen, Toonen, Ruud F., Schmitz, Sabine K., Schmitz, S.K., Cornelisse, L.N., J.J. Johannes Hjorth, Verhage, M., Georgiou, Christina, Raoul M.S. Joemai, Wijntjes, R., Matthijs Verhage, Cornelisse, L. Niels, de Bruijn, Petra, Rick Wijntjes, Arthur P.H. de Jong, Veldkamp, Wouter J. H., de Jong, Arthur P.H.   +48 more
core   +1 more source

Ingredients, Processing, and Fermentation: Addressing the Organoleptic Boundaries of Plant-Based Dairy Analogues

Foods, 2022
Consumer interest and research in plant-based dairy analogues has been growing in recent years because of increasingly negative implications of animal-derived products on human health, animal wellbeing, and the environment.
Aileen Pua, Vivien Chia Yen Tang, Rui Min Vivian Goh, Jingcan Sun, Benjamin Lassabliere, Shao Quan Liu   +5 more
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Ephrins and Eph Receptor Tyrosine Kinases in Synapse Formation

, 2009
Here, we discuss what is known about the function of ephrins and Eph receptors In synapse formation in the peripheral nervous system and central nervous system.
Daniel J. Liebl, Liebl, Daniel J., Krull, Catherine E., Catherine E. Krull   +3 more
core   +1 more source

Genetic Deletion of GABAA Receptors Reveals Distinct Requirements of Neurotransmitter Receptors for GABAergic and Glutamatergic Synapse Development

Frontiers in Cellular Neuroscience, 2019
In the adult brain GABAA receptors (GABAARs) mediate the majority of synaptic inhibition that provides inhibitory balance to excitatory drive and controls neuronal output.
Jingjing Duan, Jingjing Duan, Saurabh Pandey, Tianming Li, David Castellano, Xinglong Gu, Jun Li, Qingjun Tian, Wei Lu   +8 more
doaj   +1 more source