Results 71 to 80 of about 279,988 (315)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Procoagulant off-target effect of the direct oral anticoagulant reversal agent Andexanet alfa

Blood Vessels, Thrombosis & Hemostasis
: Patients with hemorrhage after treatment with direct oral anticoagulants (DOACs) are saved from hematoma expansion by administration of Andexanet alfa, a modified factor Xa analog.
Ischa M. S. Hoornstra, Junxiong Zhao, Harmen Middelveld, Siyu Sun, Claudia Schönichen, Johan W. M. Heemskerk, Hendrik Stragier, René Heylen, Bas de Laat, Mark Roest   +9 more
doaj   +1 more source

Proteomics of synapse [PDF]

Analytical and Bioanalytical Chemistry, 2006
Large-scale phosphoproteome analysis on synaptosome and preparation of post-synaptic density (PSD) were investigated. It was found that protein phosphor is a common event in the synapse, which is consistent with the presence of diverse classes of kinases and phosphatases in the synapse.
openaire   +3 more sources

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Geometrically repatterned immunological synapses uncover formation mechanisms

, 2006
The interaction of T cells and antigen-presenting cells is central to adaptive immunity and involves the formation of immunological synapses in many cases.
Michael Meyer-Hermann, Meyer-Hermann Michael, Meyer-Hermann, Michael (Prof. Dr.), Figge, Marc Thilo, Figge Marc Thilo, Marc Thilo Figge   +5 more
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

The Role of Non-Destructive Testing of Composite Materials for Aerospace Applications

NDT - Journal of Non-Destructive Testing
This review examines the essential application of non-destructive testing (NDT) techniques in assessing the integrity and damage of composite materials used in aerospace engineering, focusing on polymer matrix composites (PMCs), metal matrix composites ...
Thiago Luiz Lara Oliveira, Maha Hadded, Saliha Mimouni, Renata Brandelli Schaan   +3 more
doaj   +1 more source

Recycling at synapses

eLife, 2016
Synaptic vesicles in rodent neurons are recycled using at least two distinct mechanisms.
Owen P Gross, Henrique von Gersdorff
openaire   +3 more sources

Structure–Function Decoupling of the Sensorimotor and Default Mode Networks in Black Americans With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Multiple sclerosis (MS) exhibits racially disparate rates of disease progression. Black people with MS (B‐PwMS) experience a more severe disease course than non‐Hispanic White people with MS (NHW‐PwMS). Here we investigated structural and functional connectivity as well as structure–function decoupling in the ...
Emilio Cipriano, Giacomo Boffa, Maria Petracca, Marta Ponzano, Nicole Graziano, Claire Wigley, Claire Riley, Jonathan Howard, Pietro Bontempi, Sylvia Klineova, Fred Lublin, Matilde Inglese   +11 more
wiley   +1 more source

Neuromuscular synapse [PDF]

Biochemistry and Molecular Biology Education, 2009
AbstractDiverse biological data may be used to create illustrations of molecules in their cellular context. I describe the scientific results that support a recent textbook illustration of the neuromuscular synapse. The image magnifies a portion of the synapse at one million times, showing the location and the form of individual macromolecules. Results
openaire   +2 more sources