Results 71 to 80 of about 402,240 (289)
Dysregulation of microtubule stability impairs morphofunctional connectivity in primary neuronal networks [PDF]
, 2017 Functionally related neurons assemble into connected networks that process and transmit electrochemical information. To do this in a coordinated manner, the number and strength of synaptic connections is tightly regulated.
Jacobine Kuijlaars +7 more
core +2 more sources
FEBS Open Bio, EarlyView.This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake +4 more
wiley +1 more source
The Role of Non-Destructive Testing of Composite Materials for Aerospace Applications
NDT - Journal of Non-Destructive TestingThis review examines the essential application of non-destructive testing (NDT) techniques in assessing the integrity and damage of composite materials used in aerospace engineering, focusing on polymer matrix composites (PMCs), metal matrix composites ...
Thiago Luiz Lara Oliveira +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Procoagulant off-target effect of the direct oral anticoagulant reversal agent Andexanet alfa
Blood Vessels, Thrombosis & Hemostasis: Patients with hemorrhage after treatment with direct oral anticoagulants (DOACs) are saved from hematoma expansion by administration of Andexanet alfa, a modified factor Xa analog.
Ischa M. S. Hoornstra +9 more
doaj +1 more source
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
An organic nanoparticle transistor behaving as a biological synapse
, 2009 Molecule-based devices are envisioned to complement silicon devices by providing new functions or already existing functions at a simpler process level and at a lower cost by virtue of their self-organization capabilities. Moreover, they are not bound to
Abbott +32 more
core +1 more source
Age‐Related Characteristics of SYT1‐Associated Neurodevelopmental Disorder
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives We describe the clinical manifestations and developmental abilities of individuals with SYT1‐associated neurodevelopmental disorder (Baker‐Gordon syndrome) from infancy to adulthood. We further describe the neuroradiological and electrophysiological characteristics of the condition at different ages, and explore the associations ...
Sam G. Norwitz +3 more
wiley +1 more source
In vitro Assessment of Immunological Synapse Formation by Flow Cytometry
Bio-Protocol, 2016 In adaptive immune system, formation of immunological synapse between T cells and antigen presenting cells (dendritic cells, B cells, and macrophages) or target cells (tumor cells and viral-infected cells) is critical for the execution of T cell immune ...
Bo-Ra Na, Chang-Duk Jun
doaj +1 more source
A life dedicated to pharmacy [PDF]
, 2015 The Synapse meets Mary Ann Sant Fournier presently President of the Malta Chamber of Pharmacists, and visiting Senior Lecturer at the Faculty of Medicine & Surgery, UOM.peer ...
Sant Fournier, Mary Ann, The Synapse
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