Results 61 to 70 of about 279,988 (315)

The Versatile Synapse [PDF]

Journal of Experimental Biology, 1984
ABSTRACT‘Typically’ chemical synaptic transmission takes place when an influx of calcium ions during a presynaptic nerve impulse triggers exocytosis of neurotransmitter substance from synaptic vesicles. The neurotransmitter diffuses across the synaptic cleft and occupies receptors embedded in the subsynaptic membrane.
openaire   +2 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila [PDF]

, 1999
Glued1 (Gl1) mutants produce a truncated protein that acts as a poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous mutants have axonal defects in the adult eye and the nervous system.
Allen, Marcus J., Murphey, R. K., Shan, Xiaoliang, Moffat, Kevin G., Allen, Marcus James, Froggett, Stephan J., Caruccio, Phyllis, Murphey, R.K.   +7 more
core  

Synapse Dysfunctions in Multiple Sclerosis [PDF]

, 2023
Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system (CNS) affecting nearly three million humans worldwide.
Schwarz, Karin, Karin Schwarz, Schmitz, Frank, Frank Schmitz   +3 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Thrombin generation remains stable in frozen plasma over long-term storage

Thrombosis Update
Background: The ST Genesia is a fully automated thrombin generation (TG) device. Measuring TG can be useful for medical purposes as it is an indicator for the bleeding or thrombotic risk of a patient.
A. Carlo, R. de Laat-Kremers, B. de Laat, M. Ninivaggi   +3 more
doaj   +1 more source

A first-passage approach to diffusion-influenced reversible binding and its insights into nanoscale signaling at the presynapse

Scientific Reports, 2021
Synaptic transmission between neurons is governed by a cascade of stochastic calcium ion reaction–diffusion events within nerve terminals leading to vesicular release of neurotransmitter.
Maria Reva, David A. DiGregorio, Denis S. Grebenkov   +2 more
doaj   +1 more source

Synaptic Release Potentiation at Aging Auditory Ribbon Synapses

Frontiers in Aging Neuroscience, 2021
Age-related hidden hearing loss is often described as a cochlear synaptopathy that results from a progressive degeneration of the inner hair cell (IHC) ribbon synapses.
Thibault Peineau, Thibault Peineau, Séverin Belleudy, Susanna Pietropaolo, Yohan Bouleau, Yohan Bouleau, Didier Dulon, Didier Dulon   +7 more
doaj   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Neurodegeneration: New Road Leads Back to the Synapse

, 2012
Much of Parkinson’s research over the last decade has focused on cellular stress as a candidate mechanism. In this issue of Neuron, a new study by Matta et al.
Heutink, Peter, Verhage, Matthijs, Heutink, P., Verhage, M.   +3 more
core   +1 more source