Results 1 to 10 of about 16,590 (223)

Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]

PLoS ONE, 2013
Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda, Zhifei Shao, Ken D Yamaguchi, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Osamu Taguchi, Hugh Salamon, Lawrence L K Leung, Esteban C Gabazza, John Morser   +9 more
doaj   +2 more sources

Thrombomodulin is upregulated in the kidneys of women with pre-eclampsia

Scientific Reports, 2021
The endothelial glycoprotein thrombomodulin regulates coagulation, vascular inflammation and apoptosis. In the kidney, thrombomodulin protects the glomerular filtration barrier by eliciting crosstalk between the glomerular endothelium and podocytes ...
Cleo C. L. van Aanhold, Manon Bos, Katrina M. Mirabito Colafella, Marie-Louise P. van der Hoorn, Ron Wolterbeek, Jan A. Bruijn, Kitty W. M. Bloemenkamp, Anton H. van den Meiracker, A. H. Jan Danser, Hans J. Baelde   +9 more
doaj   +2 more sources

Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus

Cells, 2021
Diabetes mellitus is a global threat to human health. The ultimate cause of diabetes mellitus is insufficient insulin production and secretion associated with reduced pancreatic β-cell mass.
Yuko Okano, Atsuro Takeshita, Taro Yasuma, Masaaki Toda, Kota Nishihama, Valeria Fridman D’Alessandro, Chisa Inoue, Corina N. D’Alessandro-Gabazza, Tetsu Kobayashi, Yutaka Yano, Esteban C. Gabazza   +10 more
doaj   +2 more sources

Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism

Allergology International, 2014
Background: Thrombomodulin treatment modulates the properties of dendritic cells (DCs) converting them from immunogenic to tolerogenic and inducing its own expression on DCs.
Masaaki Toda, Corina N. D'Alessandro-Gabazza, Takehiro Takagi, Ayshwarya-Lakshmi Chelakkot-Govindalayathila, Osamu Taguchi, Ziaurahman Roeen, Seiichi Munesue, Yasuhiko Yamamoto, Hiroshi Yamamoto, Esteban C. Gabazza, John Morser   +10 more
doaj   +2 more sources

Soluble thrombomodulin activity and soluble thrombomodulin antigen in plasma [PDF]

Journal of Thrombosis and Haemostasis, 2005
Endothelial cell membrane-bound thrombomodulin (TM) plays a critical role as a cofactor in the protein C pathway, important in regulating coagulation as well as inflammation. Heterogeneous soluble TM fragments circulate in the plasma and are found at increased levels in various diseases such as cardiovascular disease and diabetes, and in ischemic and ...
A-K, Ohlin, K, Larsson, M, Hansson
exaly   +3 more sources

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

Biomedicines, 2021
Thrombomodulin is a molecule with anti-coagulant and anti-inflammatory properties. Recently, thrombomodulin was reported to be able to bind extracellular matrix proteins, such as fibronectin and collagen; however, whether thrombomodulin regulates the ...
Eiji Kawamoto, Nodoka Nago, Takayuki Okamoto, Arong Gaowa, Asami Masui-Ito, Yuichi Akama, Samuel Darkwah, Michael Gyasi Appiah, Phyoe Kyawe Myint, Gideon Obeng, Atsushi Ito, Siqingaowa Caidengbate, Ryo Esumi, Takanori Yamaguchi, Eun Jeong Park, Hiroshi Imai, Motomu Shimaoka   +16 more
doaj   +1 more source

Thrombomodulin and von willebrand factor as markers of endothelial dysfunction in patients with chronic kidney disease [PDF]

The Ukrainian Biochemical Journal, 2022
The aim of research was to study the levels of thrombomodulin (TM) and von Willebrand factor (VWF) in the serum and urine of patients with chronic kidney disease (CKD)as diagnostic markers of endothelial dysfunction.
I. S. Mykhaloiko, R. I. Yatsyshyn, N. V. Cherniuk, M. Ja. Humeniuk   +3 more
doaj   +1 more source

Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin

TH Open, 2023
Background Disseminated intravascular coagulation (DIC) is not a homogeneous condition, but rather includes heterogeneous conditions, and its pathophysiology and outcome vary considerably depending on the background.
Hideo Wada, Kazuo Kawasugi, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto   +11 more
doaj   +1 more source

Thrombomodulin in disseminated intravascular coagulation and other critical conditions—a multi-faceted anticoagulant protein with therapeutic potential

Critical Care, 2019
Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and systemic inflammation, endothelial thrombomodulin ...
Takashi Ito, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy, Toshiaki Iba   +4 more
doaj   +1 more source

Impact of Laparoscopic Sleeve Gastrectomy on Thrombomodulin Concentration and Early Markers of Atherosclerosis

Journal of Interventional Cardiology, 2022
Background. Thrombomodulin, an integral membrane protein functioning as a cofactor in the anticoagulant pathways, has recently emerged as a marker of endothelial dysfunction.
Hasan Elkan, Mehmet Memduh Baş, Berna Kaya   +2 more
doaj   +1 more source