Results 1 to 10 of about 13,946 (117)

Thrombomodulin: a potential biomarker for sepsis-associated acute kidney injury resulting from bacterial infections [PDF]

Frontiers in Cellular and Infection Microbiology
BackgroundSepsis-associated acute kidney injury (SA-AKI) is a common complication of sepsis. Serum creatinine is a delayed AKI marker influenced by multiple confounders and cannot reflect endothelial injury central to SA-AKI.
Hao Hong, Hao Hong, Mengya Xiao, Junyao Zheng, Yuting Wang, Jun Jin, Yang Xu, Ming Li   +7 more
doaj   +2 more sources

Thrombomodulin Mitigates the Progression of Hepatocellular Carcinoma in Steatotic Liver [PDF]

Journal of Hepatocellular Carcinoma
Megumi Yamaguchi,1 Hirotaka Tashiro,1,2 Shintaro Kuroda,3 Tsuyoshi Kobayashi,3 Takao Hinoi,4 Goichi Honda,5 Hideki Ohdan3 1Department of Clinical Research, Kure Medical Center and Chugoku Cancer Center, National Hospital Organization, Hiroshima, Japan ...
Yamaguchi M, Tashiro H, Kuroda S, Kobayashi T, Hinoi T, Honda G, Ohdan H   +6 more
doaj   +2 more sources

Differential gene expression in thrombomodulin (TM; CD141)(+) and TM(-) dendritic cell subsets. [PDF]

PLoS ONE, 2013
Previously we have shown in a mouse model of bronchial asthma that thrombomodulin can convert immunogenic conventional dendritic cells into tolerogenic dendritic cells while inducing its own expression on their cell surface.
Masaaki Toda, Zhifei Shao, Ken D Yamaguchi, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Osamu Taguchi, Hugh Salamon, Lawrence L K Leung, Esteban C Gabazza, John Morser   +9 more
doaj   +1 more source

Thrombomodulin is upregulated in the kidneys of women with pre-eclampsia

Scientific Reports, 2021
The endothelial glycoprotein thrombomodulin regulates coagulation, vascular inflammation and apoptosis. In the kidney, thrombomodulin protects the glomerular filtration barrier by eliciting crosstalk between the glomerular endothelium and podocytes ...
Cleo C. L. van Aanhold, Manon Bos, Katrina M. Mirabito Colafella, Marie-Louise P. van der Hoorn, Ron Wolterbeek, Jan A. Bruijn, Kitty W. M. Bloemenkamp, Anton H. van den Meiracker, A. H. Jan Danser, Hans J. Baelde   +9 more
doaj   +1 more source

The Lectin-Like Domain of Thrombomodulin Inhibits β1 Integrin-Dependent Binding of Human Breast Cancer-Derived Cell Lines to Fibronectin

Biomedicines, 2021
Thrombomodulin is a molecule with anti-coagulant and anti-inflammatory properties. Recently, thrombomodulin was reported to be able to bind extracellular matrix proteins, such as fibronectin and collagen; however, whether thrombomodulin regulates the ...
Eiji Kawamoto, Nodoka Nago, Takayuki Okamoto, Arong Gaowa, Asami Masui-Ito, Yuichi Akama, Samuel Darkwah, Michael Gyasi Appiah, Phyoe Kyawe Myint, Gideon Obeng, Atsushi Ito, Siqingaowa Caidengbate, Ryo Esumi, Takanori Yamaguchi, Eun Jeong Park, Hiroshi Imai, Motomu Shimaoka   +16 more
doaj   +1 more source

Thrombomodulin and von willebrand factor as markers of endothelial dysfunction in patients with chronic kidney disease [PDF]

The Ukrainian Biochemical Journal, 2022
The aim of research was to study the levels of thrombomodulin (TM) and von Willebrand factor (VWF) in the serum and urine of patients with chronic kidney disease (CKD)as diagnostic markers of endothelial dysfunction.
I. S. Mykhaloiko, R. I. Yatsyshyn, N. V. Cherniuk, M. Ja. Humeniuk   +3 more
doaj   +1 more source

Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin

TH Open, 2023
Background Disseminated intravascular coagulation (DIC) is not a homogeneous condition, but rather includes heterogeneous conditions, and its pathophysiology and outcome vary considerably depending on the background.
Hideo Wada, Kazuo Kawasugi, Goichi Honda, Noriaki Kawano, Toshimasa Uchiyama, Seiji Madoiwa, Naoki Takezako, Kei Suzuki, Yoshinobu Seki, Takayuki Ikezoe, Toshiaki Iba, Kohji Okamoto   +11 more
doaj   +1 more source

Thrombomodulin Modulates Dendritic Cells via Both Antagonism of High Mobility Group Protein B1 and an Independent Mechanism

Allergology International, 2014
Background: Thrombomodulin treatment modulates the properties of dendritic cells (DCs) converting them from immunogenic to tolerogenic and inducing its own expression on DCs.
Masaaki Toda, Corina N. D'Alessandro-Gabazza, Takehiro Takagi, Ayshwarya-Lakshmi Chelakkot-Govindalayathila, Osamu Taguchi, Ziaurahman Roeen, Seiichi Munesue, Yasuhiko Yamamoto, Hiroshi Yamamoto, Esteban C. Gabazza, John Morser   +10 more
doaj   +1 more source

Thrombomodulin activation driven by LXR agonist attenuates renal injury in diabetic nephropathy

Frontiers in Medicine, 2023
ObjectiveInflammation and thrombosis are recognized as interrelated biological processes. Both thrombomodulin (TM) and factor XIII-A (FXIII-A) are involved in inflammation and coagulation process.
Wei Wang, Song Wu, Amanda Y. Wang, Amanda Y. Wang, Amanda Y. Wang, Tao Wu, Haojun Luo, Jia Wei Zhao, Jin Chen, Yi Li, Hanlu Ding   +10 more
doaj   +1 more source

Effects of recombinant human soluble thrombomodulin on neutrophil extracellular traps in the kidney of a mouse model of endotoxin shock

Fujita Medical Journal, 2023
Objectives: Sepsis is a life-threatening condition characterized by multi-organ dysfunction due to host immune system dysregulation in response to an infection.
Tatsuhiko Harada, Yasuyo Shimomura, Osamu Nishida, Munenori Maeda, Yu Kato, Tomoyuki Nakamura, Naohide Kuriyama, Hidefumi Komura   +7 more
doaj   +1 more source