Results 21 to 30 of about 17,882 (212)

Hypercoagulability in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD): Causes and Consequences

Biomedicines, 2022
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and it is anticipated that it could become even more prevalent in parallel with an increase in the incidence of metabolic diseases closely related to NAFLD, such as ...
Armando Tripodi, Rosa Lombardi, Massimo Primignani, Vincenzo La Mura, Flora Peyvandi, Anna L. Fracanzani   +5 more
doaj   +1 more source

Multicenter Interlaboratory Study of Thrombin Generation Assay in Healthy Adults Using the ST Genesia Analyzer With the STG-ThromboScreen Reagent (With and Without Thrombomodulin). [PDF]

Int J Lab Hematol
ABSTRACT Introduction Fully automated thrombin generation (TG) assays facilitate the transition from research to clinical application. We conducted a multicenter inter‐laboratory study using the ST Genesia analyzer to evaluate assay performance and establish reference intervals in healthy adults from Spain and Portugal.
Velasco-Rodríguez D, Marcos-Jubilar M, Martínez-Alfonzo I, Martos L, Aguilar C, Vilalta N, Llobet D, Marco-Rico A, Aragoneses D, Marco P, Ricca L, Ferreira D, Lopes S, Mariano-Pego J, Bernardo Á, Moscardó A, Bonanad S, Gassiot S, Gutiérrez-Jomarrón I, Páramo JA, Llamas-Sillero P, Reverter JC.   +21 more
europepmc   +2 more sources

Reduced glomerular endothelial thrombomodulin is associated with glomerular macrophage infiltration in diabetic nephropathy [PDF]

, 2021
The endothelial glycoprotein thrombomodulin regulates coagulation, inflammation, and apoptosis. In diabetic mice, reduced thrombomodulin function results in diabetic nephropathy (DN).
Berg, B.M. van den, Baelde, H.J., Bos, M., Dijkstra, K.L., Bruijn, J.A., Aanhold, C.C.L. van, Wolterbeek, R., Bajema, I.M.   +7 more
core   +1 more source

Thrombomodulin in disseminated intravascular coagulation and other critical conditions—a multi-faceted anticoagulant protein with therapeutic potential

Critical Care, 2019
Thrombomodulin plays a vital role in maintaining intravascular patency due to its anticoagulant, antiinflammatory, and cytoprotective properties. However, under pathological conditions such as sepsis and systemic inflammation, endothelial thrombomodulin ...
Takashi Ito, Jecko Thachil, Hidesaku Asakura, Jerrold H. Levy, Toshiaki Iba   +4 more
doaj   +1 more source

Functional and Immunoreactive Thrombomodulin Expressed by Keratinocytes [PDF]

, 1994
In an immunohistopathologic study using two monoclonal antibodies that recognize independent epitopes on human thrombomodulin, we detected expression of thrombomodulin on Malpighian-layer keratinocytes, but not on the basal or upper granular-layer ...
Hayashi, Tatsuya, Hashimoto, Koji, Shimizu, Masayuki, Ohyanagi, Satoshi, Nouchi, Nobuhiro, Mizutani, Hitoshi, Suzuki, Koji   +6 more
core   +1 more source

Case report: A rare case of recurrent right atrial mass dramatically disappeared after anticoagulation

Frontiers in Cardiovascular Medicine, 2022
A young man repeatedly found a right atrial mass with severe wheezing and extreme dyspnea. His condition was critical and complicated. The process of correct diagnosis was full of twists and turns.
Huarui Wang, Jie Zi, Qiao Li, Yuanyuan Sun, Ling Zhu   +4 more
doaj   +1 more source

Endothelial cell activation and glycocalyx shedding - potential as biomarkers in patients with lupus nephritis

Frontiers in Immunology, 2023
Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus and an important cause of acute and chronic kidney injury. Early diagnosis of LN and preventing relapses are key to preserving renal reserve.
Susan Yung, Tak Mao Chan
doaj   +1 more source

Evaluation of thrombomodulin and pentraxin-3 as diagnostic biomarkers in calves with sepsis

Veterinární Medicína, 2018
Early diagnosis and treatment of sepsis in patients are crucial for their survival and can help reduce mortality rates. Novel biomarkers, such as thrombomodulin and pentraxin-3, have been used as diagnostic, prognostic and mortality indicators in ...
O. Aygun, R. Yildiz
doaj   +1 more source

Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]

, 2010
Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Welsch, Ulrich, Peter Conzen, Bruegger, Dirk, Jacob, Matthias, Ingo Kaczmarek, Kaczmarek, Ingo, Conzen, Peter, Becker, Bernhard F., Stoeckelhuber, Mechthild, Rehm, Markus, Daniel Chappell, Dirk Bruegger, Chappell, Daniel, Bernhard F. Becker, Markus Rehm, Matthias Jacob, Ulrich Welsch, Mechthild Stoeckelhuber   +17 more
core   +1 more source

Therapeutic Role of Recombinant Human Soluble Thrombomodulin for Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Medicina, 2019
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is an acute respiratory worsening of unidentifiable cause that sometimes develops during the clinical course of IPF. Although the incidence of AE-IPF is not high, prognosis is poor.
Takuma Isshiki, Susumu Sakamoto, Sakae Homma   +2 more
doaj   +1 more source