Results 21 to 30 of about 16,590 (223)

Perspectives in Microvascular Fluid Handling: Does the Distribution of Coagulation Factors in Human Myocardium Comply with Plasma Extravasation in Venular Coronary Segments? [PDF]

, 2010
Background: Heterogeneity of vascular permeability has been suggested for the coronary system. Whereas arteriolar and capillary segments are tight, plasma proteins pass readily into the interstitial space at venular sites.
Welsch, Ulrich, Peter Conzen, Bruegger, Dirk, Jacob, Matthias, Ingo Kaczmarek, Kaczmarek, Ingo, Conzen, Peter, Becker, Bernhard F., Stoeckelhuber, Mechthild, Rehm, Markus, Daniel Chappell, Dirk Bruegger, Chappell, Daniel, Bernhard F. Becker, Markus Rehm, Matthias Jacob, Ulrich Welsch, Mechthild Stoeckelhuber   +17 more
core   +1 more source

Case report: A rare case of recurrent right atrial mass dramatically disappeared after anticoagulation

Frontiers in Cardiovascular Medicine, 2022
A young man repeatedly found a right atrial mass with severe wheezing and extreme dyspnea. His condition was critical and complicated. The process of correct diagnosis was full of twists and turns.
Huarui Wang, Jie Zi, Qiao Li, Yuanyuan Sun, Ling Zhu   +4 more
doaj   +1 more source

Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus [PDF]

, 2023
三重大学博士(医学)application/pdfDiabetes mellitus is a global threat to human health. The ultimate cause of diabetes mellitus is insufficient insulin production and secretion associated with reduced pancreatic β-cell mass.Apoptosis is an important and well ...
Okano, Yuko, オカノ, ユウコ, 岡野, 優子   +2 more
core   +1 more source

Thrombomodulin-expressing monocytes are associated with low-risk features in myelodysplastic syndromes and dampen excessive immune activation

Haematologica, 2020
The bone marrow of patients with low-risk myelodysplastic syndromes (MDS) is often an inflammatory environment and associated with an active cellular immune response.
Nathalie van Leeuwen-Kerkhoff, Theresia M. Westers, Pino J. Poddighe, Tanja D. de Gruijl, Shahram Kordasti, Arjan A. van de Loosdrecht   +5 more
doaj   +1 more source

Endothelial cell activation and glycocalyx shedding - potential as biomarkers in patients with lupus nephritis

Frontiers in Immunology, 2023
Lupus nephritis (LN) is a common and severe manifestation of systemic lupus erythematosus and an important cause of acute and chronic kidney injury. Early diagnosis of LN and preventing relapses are key to preserving renal reserve.
Susan Yung, Tak Mao Chan
doaj   +1 more source

Assessment of Serum Thrombomodulin in Patients with Systemic Lupus Erythematosus in Rheumatology Research Center [PDF]

Acta Medica Iranica, 2009
At present, some clinical presentations and serological parameters such as products of complement activation and elevation of autoantibodies (e.g. dsDNA antibodies), erythrocyte sedimentation rate (ESR), levels of C-reactive protein (CRP), or cytokines ...
Mahmood Akbarian, Farhad Gharibdoost, Mehrzad Hadjaliloo, Abdolhadi Nadji, Ahmad Reza Jamshidi, Farhad Shahram, Masoomeh Akhlaghi, Shahrzad Khosravi, Simin Almasi, Fereydoun Davatchi   +9 more
doaj   +1 more source

Increased serum thrombomodulin level is associated with disease severity and mortality in pediatric sepsis.

PLoS ONE, 2017
BackgroundEndothelial dysfunction plays an important role in the pathophysiology of sepsis. As previously reported, the serum thrombomodulin is elevated in diseases associated with endothelial injury.ObjectiveThe aim of this study was to investigate the ...
Jainn-Jim Lin, Hsiang-Ju Hsiao, Oi-Wa Chan, Yu Wang, Shao-Hsuan Hsia, Cheng-Hsun Chiu   +5 more
doaj   +1 more source

Normal thrombin generation in neonates in spite of prolonged conventional coagulation tests

Haematologica, 2008
Conventional coagulation tests might be inadequate to explore mechanisms regulating thrombin generation in neonates, because they do not allow full activation of the reduced levels of protein C.
Armando Tripodi, Luca A. Ramenghi, Veena Chantarangkul, Agnese De Carli, Marigrazia Clerici, Michela Groppo, Fabio Mosca, Pier Mannuccio Mannucci   +7 more
doaj   +1 more source

Reduced glomerular endothelial thrombomodulin is associated with glomerular macrophage infiltration in diabetic nephropathy

, 2021
The endothelial glycoprotein thrombomodulin regulates coagulation, inflammation, and apoptosis. In diabetic mice, reduced thrombomodulin function results in diabetic nephropathy (DN).
Berg, B.M. van den, Baelde, H.J., Bos, M., Dijkstra, K.L., Bruijn, J.A., Aanhold, C.C.L. van, Wolterbeek, R., Bajema, I.M.   +7 more
core   +1 more source

High plasma thrombomodulin level is associated with a decreased risk of cognitive impairment after ischemic stroke

Journal of Stroke and Cerebrovascular Diseases
Background: Thrombomodulin, a thrombin receptor with anticoagulant, anti-inflammatory, and cytoprotective properties, has been suggested to play a pivotal role in ischemic stroke.
Yu He, MD, Xinyue Chang, MD, Yi Liu, MD, Jiawen Fei, MD, Xiaoli Qin, MD, Beiping Song, MD, Quan Yu, MD, Mengyao Shi, MD, PhD, Daoxia Guo, MD, PhD, Jing Chen, MD, MS, Aili Wang, MD, PhD, Tan Xu, MD, PhD, Jiang He, MD, PhD, Yonghong Zhang, MD, PhD, Zhengbao Zhu, MD, PhD   +14 more
doaj   +1 more source