Results 11 to 20 of about 16,590 (223)

Placental thrombomodulin expression in recurrent miscarriage [PDF]

Reproductive Biology and Endocrinology, 2010
Background Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it'
Turi Angelo, Sartini Davide, Giannubilo Stefano R, Cecati Monia, Stortoni Piergiorgio, Emanuelli Monica, Tranquilli Andrea L   +6 more
doaj   +2 more sources

Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

Critical Care Research and Practice, 2012
Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis ...
Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka   +3 more
doaj   +2 more sources

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +2 more sources

Therapeutic Role of Recombinant Human Soluble Thrombomodulin for Acute Exacerbation of Idiopathic Pulmonary Fibrosis

Medicina, 2019
Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) is an acute respiratory worsening of unidentifiable cause that sometimes develops during the clinical course of IPF. Although the incidence of AE-IPF is not high, prognosis is poor.
Takuma Isshiki, Susumu Sakamoto, Sakae Homma   +2 more
doaj   +2 more sources

Resistance to thrombomodulin correlates with liver stiffness in chronic liver disease a prospective single-center cohort study. [PDF]

, 2021
INTRODUCTION Chronic liver disease (CLD) is characterized by changes in haemostasis, embracing both hypo- and hypercoagulability. Global hemostatic tests such as thrombin generation assays evaluate the hemostatic balance, to better assess bleeding and
Berzigotti, Annalisa, Calzavarini, Sara, De Gottardi, Andrea, Brodard, Justine, Quarroz, Claudia, Angelillo-Scherrer, Anne   +5 more
core   +1 more source

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions [PDF]

, 2015
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone.
Simmonds, RE, Esmon Charles T., Gerd Pluschke, Alexander Stainer, Alexander Stainer (771266), Josefin Ahnström (771267), Vogel Moritz, Stainer Alexander, Wu, HL, Hua-Lin Wu (70210), Ruf, Marie-Thérèse, Pluschke, G, Belinda S. Hall, Vogel, Moritz, Ahnström Josefin, Simmonds Rachel E., Vogel, M, Hall Belinda S., Marie-Thérèse Ruf (2280196), Simmonds, Rachel E., Ogbechi Joy, Moritz Vogel, Moritz Vogel (267190), Hall, Belinda S., Stainer, Alexander, Behr, Marcel A., Katherine Bodman-Smith, Josefin Ahnström, Bodman-Smith, K, Esmon, Charles T., Ogbechi, J, Ahnström, J, Rachel E Simmonds, Charles T. Esmon, Pluschke, Gerd, Charles T Esmon, Wu, Hua-Lin, Joy Ogbechi (546561), Hua-Lin Wu, Charles T. Esmon (280612), Joy Ogbechi, Bodman-Smith Katherine, Marie-Thérèse Ruf, Esmon, CT, Katherine Bodman-Smith (771265), Belinda S. Hall (546558), Rachel E. Simmonds, Wu Hua-Lin, Ruf Marie-Thérèse, Pluschke Gerd, Ruf, MT, Ahnström, Josefin, Gerd Pluschke (7855), Ogbechi, Joy, Stainer, A, Belinda S Hall, Rachel E. Simmonds (546562), Bodman-Smith, Katherine, Hall, BS   +58 more
core   +1 more source

Thrombomodulin activation driven by LXR agonist attenuates renal injury in diabetic nephropathy

Frontiers in Medicine, 2023
ObjectiveInflammation and thrombosis are recognized as interrelated biological processes. Both thrombomodulin (TM) and factor XIII-A (FXIII-A) are involved in inflammation and coagulation process.
Wei Wang, Song Wu, Amanda Y. Wang, Amanda Y. Wang, Amanda Y. Wang, Tao Wu, Haojun Luo, Jia Wei Zhao, Jin Chen, Yi Li, Hanlu Ding   +10 more
doaj   +1 more source

Effects of recombinant human soluble thrombomodulin on neutrophil extracellular traps in the kidney of a mouse model of endotoxin shock

Fujita Medical Journal, 2023
Objectives: Sepsis is a life-threatening condition characterized by multi-organ dysfunction due to host immune system dysregulation in response to an infection.
Tatsuhiko Harada, Yasuyo Shimomura, Osamu Nishida, Munenori Maeda, Yu Kato, Tomoyuki Nakamura, Naohide Kuriyama, Hidefumi Komura   +7 more
doaj   +1 more source

Evaluation of thrombomodulin and pentraxin-3 as diagnostic biomarkers in calves with sepsis

Veterinární Medicína, 2018
Early diagnosis and treatment of sepsis in patients are crucial for their survival and can help reduce mortality rates. Novel biomarkers, such as thrombomodulin and pentraxin-3, have been used as diagnostic, prognostic and mortality indicators in ...
O. Aygun, R. Yildiz
doaj   +1 more source

Hypercoagulability in Patients with Non-Alcoholic Fatty Liver Disease (NAFLD): Causes and Consequences

Biomedicines, 2022
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and it is anticipated that it could become even more prevalent in parallel with an increase in the incidence of metabolic diseases closely related to NAFLD, such as ...
Armando Tripodi, Rosa Lombardi, Massimo Primignani, Vincenzo La Mura, Flora Peyvandi, Anna L. Fracanzani   +5 more
doaj   +1 more source