Results 11 to 20 of about 17,882 (212)

Placental thrombomodulin expression in recurrent miscarriage [PDF]

Reproductive Biology and Endocrinology, 2010
Background Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it'
Turi Angelo, Sartini Davide, Giannubilo Stefano R, Cecati Monia, Stortoni Piergiorgio, Emanuelli Monica, Tranquilli Andrea L   +6 more
doaj   +2 more sources

Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis

Critical Care Research and Practice, 2012
Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. Therapeutic approaches that simultaneously target both inflammation and coagulation hold great promise for the treatment of sepsis ...
Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka   +3 more
doaj   +2 more sources

Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus

Cells, 2021
Diabetes mellitus is a global threat to human health. The ultimate cause of diabetes mellitus is insufficient insulin production and secretion associated with reduced pancreatic β-cell mass.
Yuko Okano, Atsuro Takeshita, Taro Yasuma, Masaaki Toda, Kota Nishihama, Valeria Fridman D’Alessandro, Chisa Inoue, Corina N. D’Alessandro-Gabazza, Tetsu Kobayashi, Yutaka Yano, Esteban C. Gabazza   +10 more
doaj   +2 more sources

Thrombomodulin-modified thrombin generation after in vivo recombinant factor VIII treatment in severe hemophilia A

Haematologica, 2008
Background Thrombin generation has been shown to reflect coagulation potential and factor VIII (FVIII) levels in patients with hemophilia A. We hypothesize that thrombin generation in the presence of thrombomodulin reflects plasma FVIII levels better ...
Arne W.J.H. Dielis, Wolfgang M.R. Balliël, René van Oerle, Wim T. Hermens, Henri M.H. Spronk, Hugo ten Cate, Karly Hamulyák   +6 more
doaj   +2 more sources

Establishment of Reference Intervals for Thrombus Biomarkers in a Single-Center Chinese Population Using Indirect Methods. [PDF]

J Clin Lab Anal
This study established and validated comprehensive RIs for four key thrombus biomarkers (TAT, PIC, TM, and t‐PAIC) in a Chinese population using the Hoffmann and Bhattacharya indirect methods on a large clinical dataset. The tailored RIs offer a practical tool for early detection and risk assessment of thrombotic diseases, supporting more precise and ...
Zhang L, Hu Q, Chen Y, Yuan H.
europepmc   +2 more sources

Targeting Oxidative and Immune Dysregulation in Wound Healing via Gold Nanoparticle Conjugate Chitosan. [PDF]

FASEB J
This gold nanoparticle–chitosan (AuNP@chitosan) composite promotes burn wound healing by simultaneously regulating endothelial and immune responses. In vitro, the composite protects TNF‐α‐injured HUVECs by reducing ROS, restoring thrombomodulin, and upregulating hypoxia‐adaptive markers.
Hsu SD, Chang SJ, Lin CA, Fan GY, Tsai HD, Lin A, Cherng JH.   +6 more
europepmc   +2 more sources

Thrombophilic thrombomodulin variants

Blood
In this issue of Blood, Van Laer et al have expressed and extensively characterized 8 thrombomodulin (TM) variants of uncertain significance identified in patients with venous thromboembolism (VTE) or bleeding, demonstrating defective anticoagulant activity in 2 of them (L433P and C175S).1 Their findings, reported in this issue of Blood, support a ...
Castoldi, Elisabetta
openaire   +3 more sources

Resistance to thrombomodulin correlates with liver stiffness in chronic liver disease a prospective single-center cohort study. [PDF]

, 2021
INTRODUCTION Chronic liver disease (CLD) is characterized by changes in haemostasis, embracing both hypo- and hypercoagulability. Global hemostatic tests such as thrombin generation assays evaluate the hemostatic balance, to better assess bleeding and
Berzigotti, Annalisa, Calzavarini, Sara, De Gottardi, Andrea, Brodard, Justine, Quarroz, Claudia, Angelillo-Scherrer, Anne   +5 more
core   +2 more sources

Mycolactone-dependent depletion of endothelial cell thrombomodulin is strongly associated with fibrin deposition in Buruli ulcer lesions [PDF]

, 2015
A well-known histopathological feature of diseased skin in Buruli ulcer (BU) is coagulative necrosis caused by the Mycobacterium ulcerans macrolide exotoxin mycolactone.
Simmonds, RE, Esmon Charles T., Gerd Pluschke, Alexander Stainer, Alexander Stainer (771266), Josefin Ahnström (771267), Vogel Moritz, Stainer Alexander, Wu, HL, Hua-Lin Wu (70210), Ruf, Marie-Thérèse, Pluschke, G, Belinda S. Hall, Vogel, Moritz, Ahnström Josefin, Simmonds Rachel E., Vogel, M, Hall Belinda S., Marie-Thérèse Ruf (2280196), Simmonds, Rachel E., Ogbechi Joy, Moritz Vogel, Moritz Vogel (267190), Hall, Belinda S., Stainer, Alexander, Behr, Marcel A., Katherine Bodman-Smith, Josefin Ahnström, Bodman-Smith, K, Esmon, Charles T., Ogbechi, J, Ahnström, J, Rachel E Simmonds, Charles T. Esmon, Pluschke, Gerd, Charles T Esmon, Wu, Hua-Lin, Joy Ogbechi (546561), Hua-Lin Wu, Charles T. Esmon (280612), Joy Ogbechi, Bodman-Smith Katherine, Marie-Thérèse Ruf, Esmon, CT, Katherine Bodman-Smith (771265), Belinda S. Hall (546558), Rachel E. Simmonds, Wu Hua-Lin, Ruf Marie-Thérèse, Pluschke Gerd, Ruf, MT, Ahnström, Josefin, Gerd Pluschke (7855), Ogbechi, Joy, Stainer, A, Belinda S Hall, Rachel E. Simmonds (546562), Bodman-Smith, Katherine, Hall, BS   +58 more
core   +2 more sources

Protective Role of Recombinant Human Thrombomodulin in Diabetes Mellitus [PDF]

, 2023
三重大学博士(医学)application/pdfDiabetes mellitus is a global threat to human health. The ultimate cause of diabetes mellitus is insufficient insulin production and secretion associated with reduced pancreatic β-cell mass.Apoptosis is an important and well ...
Okano, Yuko, オカノ, ユウコ, 岡野, 優子   +2 more
core   +2 more sources