Results 1 to 10 of about 42,405 (307)

Thrombin-Receptor Activation and Thrombin-Induced Brain Tolerance [PDF]

Journal of Cerebral Blood Flow and Metabolism, 2002
The authors previously found that pretreatment with a low dose of thrombin attenuates the brain edema induced by a large dose of thrombin or an intracerebral hemorrhage, and reduces infarct volume after focal cerebral ischemia (i.e., thrombin preconditioning).
Ya Hua, Richard F Keep, Julian T Hoff
exaly   +3 more sources

Signaling bias of the protease-activated receptor-1 is dictated by distinct GRK5 and β-arrestin-2 determinants [PDF]

Cell Reports
Summary: G protein-coupled receptors (GPCRs) exhibit signaling bias or preferential activation of heterotrimeric G proteins versus GPCR kinase (GRK)-mediated β-arrestin signaling.
Monica L. Gonzalez Ramirez, Lennis B. Orduña-Castillo, Carolyne Bardeleben, Huaping Qin, Ying Lin, Cierra A. Birch, Irina Kufareva, JoAnn Trejo   +7 more
doaj   +2 more sources

Protease-activated receptor 1 as an endogenous model of peptidergic Gαq-Gα12-biased G protein signaling [PDF]

Frontiers in Molecular Biosciences
IntroductionG protein-coupled receptors (GPCRs) are the most widely targeted class of signaling proteins, comprising ∼30% of FDA-approved drugs.
Braden S. Fallon, Robert A. Campbell, Justin G. English   +2 more
doaj   +2 more sources

ROS disrupt COP9 signalosome-mediated ABCA1 protection and trigger its ubiquitination and degradation by cullin3 inhibiting cholesterol efflux and promoting foam cell formation in response to GPCR agonists [PDF]

Redox Biology
In this study, we investigated the intricate mechanisms underlying thrombin and Ang II-induced depletion of ABCA1. Under basal conditions, the COP9 signalosome interacts with ABCA1 as a whole complex rather than as individual subunits. In the presence of
Suresh Govatati, Chandra Sekhar Yadavalli, James G. Traylor, Jr, A. Wayne Orr, Gadiparthi N. Rao   +4 more
doaj   +2 more sources

Effects of Heparin and Bivalirudin on Thrombin-Induced Platelet Activation: Differential Modulation of PAR Signaling Drives Divergent Prothrombotic Responses

Frontiers in Cardiovascular Medicine, 2021
Heparin and bivalirudin are widely used as anticoagulants in the setting of acute thrombosis. In this study, we investigated how these drugs affect the ability of thrombin to generate a prothrombotic platelet response via activation of the protease ...
Mikael Lund, Ankit S. Macwan, Kjersti Tunströmer, Tomas L. Lindahl, Tomas L. Lindahl, Niklas Boknäs, Niklas Boknäs   +6 more
doaj   +1 more source

Interplay Between Angiotensin II Type 1 Receptor and Thrombin Receptor Revealed by Bioluminescence Resonance Energy Transfer Assay

Frontiers in Pharmacology, 2020
The key hormone of the renin-angiotensin system (RAS), angiotensin II (AngII), and thrombin are known to play major roles in the vascular system and its related disorders.
Isra Al Zamel, Abdulrasheed Palakkott, Arshida Ashraf, Rabah Iratni, Mohammed Akli Ayoub   +4 more
doaj   +1 more source

Thrombin acts as inducer of proinflammatory macrophage migration inhibitory factor in astrocytes following rat spinal cord injury

Journal of Neuroinflammation, 2022
Background The danger-associated molecular patterns (DAMPs) are critical contributors to the progressive neuropathology and thereafter affect the functional outcomes following spinal cord injury (SCI).
Ting Yang, Haiyan Jiang, Xinye Luo, Yuxuan Hou, Aicheng Li, Bingqiang He, Xingyuan Zhang, Huifei Hao, Honghua Song, Rixin Cai, Xudong Wang, Yingjie Wang, Chun Yao, Lei Qi, Yongjun Wang   +14 more
doaj   +1 more source

Thrombin induces a temporal biphasic vascular response through the differential phosphorylation of endothelial nitric oxide synthase via protease-activated receptor-1 and protein kinase C

Journal of Pharmacological Sciences, 2022
Endothelial nitric oxide synthase (eNOS) is a critical regulatory enzyme that controls vascular tone via the production of nitric oxide. Although thrombin also modulates vascular tone predominantly via the activation of protease-activated receptors (PARs)
Akihiro Okamura, Junichiro Miake, Takuya Tomomori, Aiko Takami, Tatsuya Sawano, Masaru Kato, Kazuyoshi Ogura, Daiki Tsujimoto, Shunsuke Kawatani, Kurniawan Priyono Agung, Tomomi Notsu, Ichiro Hisatome, Kazuhiro Yamamoto, Takeshi Imamura   +13 more
doaj   +1 more source

Dynamic allostery in thrombin—a review

Frontiers in Molecular Biosciences, 2023
Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C ...
Elizabeth A. Komives
doaj   +1 more source

Activation‐induced changes in platelet surface receptor expression and the contribution of the large‐platelet subpopulation to activation

Research and Practice in Thrombosis and Haemostasis, 2020
Objective Platelet surface receptors are also present subcellularly in organelle membranes and can be expressed on the surface upon platelet activation. However, some receptors were reported to be decreased after activation.
Masaaki Moroi, Richard W. Farndale, Stephanie M. Jung   +2 more
doaj   +1 more source