Results 31 to 40 of about 42,405 (307)

Thrombin Receptor Structure and Function

Cold Spring Harbor Symposia on Quantitative Biology, 1992
Thrombin is a multifunctional serine protease generated at sites of vascular injury. While it is best known for its ability to cleave fibrinogen and trigger fibrin formation, thrombin is also a powerful agonist for a variety of cellular responses. First and foremost, thrombin is the most potent activator of platelets in vitro.
S R, Coughlin, R M, Scarborough, T K, Vu, D T, Hung   +3 more
openaire   +2 more sources

Calcium mobilization and protein kinase C activation downstream of protease activated receptor 4 (PAR4) is negatively regulated by PAR3 in mouse platelets. [PDF]

PLoS ONE, 2013
Thrombin activates platelets through protease activated receptors (PARs). Mouse platelets express PAR3 and PAR4. PAR3 does not signal in platelets. However, PAR4 is a relatively poor thrombin substrate and requires PAR3 as a cofactor at low thrombin ...
Amal Arachiche, María de la Fuente, Marvin T Nieman   +2 more
doaj   +1 more source

Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones

Molecular Pain, 2010
Protease-activated receptors (PAR1-4) are activated by proteases released by cell damage or blood clotting, and are known to be involved in promoting pain and hyperalgesia.
Magherini Pier C, Reeh Peter, Hechtfischer Sabine C, Prandini Massimiliano, Kinsey Anna M, Vellani Vittorio, Giacomoni Chiara, McNaughton Peter A   +7 more
doaj   +1 more source

C1-inhibitor influence on platelet activation by thrombin receptors agonists

Clinical and Applied Thrombosis/Hemostasis, 2022
Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet activation. Data on platelet activation are extrapolated across experimental settings.
Ivan D. Tarandovskiy PhD, Paul W. Buehler PhD, Elena Karnaukhova PhD   +2 more
doaj   +1 more source

A Bacterial Surface Display System Expressing Cleavable Capsid Proteins of Human Norovirus: A Novel System to Discover Candidate Receptors

Frontiers in Microbiology, 2017
Human noroviruses (HuNoVs) are the dominant cause of food-borne outbreaks of acute gastroenteritis. However, fundamental researches on HuNoVs, such as identification of viral receptors have been limited by the currently immature system to culture HuNoVs ...
Qian Xu, Pei’en Ni, Danlei Liu, Yujie Yin, Qianqian Li, Jvmei Zhang, Qingping Wu, Peng Tian, Xianming Shi, Dapeng Wang   +9 more
doaj   +1 more source

Altered protease-activated receptor-1 expression and signaling in a malignant pleural mesothelioma cell line, NCI-H28, with homozygous deletion of the β-catenin gene. [PDF]

PLoS ONE, 2014
Protease activated receptors (PARs) are G-protein coupled receptors that are activated by an unique proteolytic mechanism. These receptors play crucial roles in hemostasis and thrombosis but also in inflammation and vascular development.
Alessandra Fazzini, Vanessa D'Antongiovanni, Laura Giusti, Ylenia Da Valle, Federica Ciregia, Ilaria Piano, Antonella Caputo, Anna Maria D'Ursi, Claudia Gargini, Antonio Lucacchini, Maria Rosa Mazzoni   +10 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

PAR-1 signaling on macrophages is required for effective in vivo delayed-type hypersensitivity responses

iScience, 2021
Summary: Delayed-type hypersensitivity (DTH) responses underpin chronic inflammation. Using a model of oxazolone-induced dermatitis and a combination of transgenic mice, adoptive cell transfer, and selective agonists/antagonists against protease ...
Hannah Wilkinson, Hugh Leonard, Daxin Chen, Toby Lawrence, Michael Robson, Pieter. Goossens, John H. McVey, Anthony Dorling   +7 more
doaj   +1 more source

Thrombin and protease-activated receptors in cancer

, 2003
Results from clinical studies indicate a strong association between thromboembolism and solid malignancy. Being central to blood coagulation and displaying a number of cellular postclotting activities, the serine protease thrombin has been localized ...
Steiner, Michael; University of Rostock, Liu, Jian; University of Rostock, Schuf-Werner, Peter; University of Rostock   +2 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source