Results 11 to 20 of about 42,405 (307)

Internalization and recycling of activated thrombin receptors [PDF]

Journal of Biological Chemistry, 1993
Shortly after activation by either thrombin or the tethered ligand domain peptide SFLLRN, thrombin receptors undergo homologous desensitization, temporarily losing their ability to respond to both agonists. We have examined the role of receptor internalization and recycling in this process using receptor-directed antibodies as probes.
Hoxie, James A., Ahuja, Menaka, Belmonte, Elizabeth, Pizarro, Shelly, Parton, Robert, Brass, Lawrence F.   +5 more
openaire   +5 more sources

Molecular Recognition with Biological Receptors: Structure-Based Design of Thrombin Inhibitors

CHIMIA, 2000
Molecular recognition is at the center of biological function. Consequently, a profound understanding of the underlying nonbonding interactions is required to intervene in a rational way in biological processes.
Patrick Betschmann, Christian Lerner, Stefan Sahli, Ulrike Obst, François Diederich   +4 more
doaj   +3 more sources

Constitutive Expression of Functionally Active Protease-Activated Receptors 1 and 2 in Human Conjunctival Epithelial Cells

Mediators of Inflammation, 2006
Protease-activated receptors (PARs) are G-protein-coupled receptors which initiate inflammatory responses when activated by specific serine proteases.
Timothy J. Nickel, Mohammad H. Kabir, Jaya Talreja, Daniel J. Stechschulte, Kottarappat N. Dileepan   +4 more
doaj   +2 more sources

Factor Xa and thrombin induce endothelial progenitor cell activation. The effect of direct oral anticoagulants

Platelets, 2021
Factor Xa (FXa) and thrombin exert non-hemostatic cellular actions primarily mediated through protease-activated receptors (PARs). We investigated the effect of FXa and thrombin on human late-outgrowth endothelial cells (OECs), a type of endothelial ...
Styliani Papadaki, Sofia Sidiropoulou, Iraklis C. Moschonas, Alexandros D. Tselepis   +3 more
doaj   +1 more source

Thrombin increases inflammatory cytokine and angiogenic growth factor secretion in human adipose cells in vitro

Journal of Inflammation, 2009
Background Abdominal obesity is associated with pro-thrombotic and inflammatory states. Therefore, the purpose of this study was to examine the expression of thrombin receptors (PAR1 and PAR4) human adipose tissue and whether thrombin stimulates an ...
Phillips Shane A, Strande Jennifer L
doaj   +1 more source

Treating seizures and epilepsy with anticoagulants?

Frontiers in Cellular Neuroscience, 2013
Thrombin is a serine protease playing an essential role in the blood coagulation cascade. Recent work, however, has identified a novel role for thrombin-mediated signaling pathways in the central nervous system.
Nicola eMaggio, Ilan eBlatt, Andreas eVlachos, David eTanne, Joab eChapman, Menahem eSegal   +5 more
doaj   +1 more source

Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis

Pharmaceuticals, 2013
Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease.
Susan S. Smyth, Eric L. Wallace
doaj   +1 more source

Mice lacking protease nexin-1 show delayed structural and functional recovery after sciatic nerve crush [PDF]

, 2007
Multiple molecular mechanisms influence nerve regeneration. Because serine proteases were shown to affect peripheral nerve regeneration, we performed nerve crush experiments to study synapse reinnervation in adult mice lacking the serpin protease nexin-1
Atanasoski, Suzana, Suter, Ueli, Kvajo, Mirna, Fayard, Bérengère, Moreno, Eliza, Lino, Maria Maddalena, Brenner, Hans Rudolf, Monard, Denis   +7 more
core   +1 more source

Thrombin Promotes Matrix Metalloproteinase-13 Expression through the PKCδ/c-Src/EGFR/PI3K/Akt/AP-1 Signaling Pathway in Human Chondrocytes

Mediators of Inflammation, 2013
Thrombin is a key mediator of fibrin deposition, angiogenesis, and proinflammatory processes. Abnormalities in these processes are primary features of rheumatoid arthritis and osteoarthritis.
Chun-Yin Huang, Hsiu-Jung Lin, Hsin-Shui Chen, Shi-Yann Cheng, Horng-Chaung Hsu, Chih-Hsin Tang   +5 more
doaj   +1 more source

Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902

Platelets, 2021
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PAR4 ...
Simeng Li, Volga Tarlac, Roberto B. I. Christanto, Shauna L. French, Justin R. Hamilton   +4 more
doaj   +1 more source