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Protease‐activated receptors: An illustrated review [PDF]
Research and Practice in Thrombosis and Haemostasis, 2021 Proteases are important regulators of cell behavior, survival, and apoptosis. They communicate to cells directly through a special class of G‐protein–coupled receptors known as protease‐activated receptors (PARs). N‐terminal PAR proteolysis unmasks a neo‐
Xu Han +2 more
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Biased Signaling of Protease-activated Receptors [PDF]
Frontiers in Endocrinology, 2014 In addition to their role in protein degradation and digestion, proteases can also function as hormone-like signaling molecules that regulate vital patho-physiological processes, including inflammation, hemostasis, pain and repair mechanisms.
Peishen eZhao +3 more
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Corrigendum: Biased signaling of protease-activated receptors [PDF]
Frontiers in Endocrinology, 2015 Figure Figure33 shows a snake diagram of the N-terminal amino acid sequence of human protease-activated receptor (PAR2). It indicates the sites at which different proteases cleave PAR2. These sites are correct. The error is that we accidentally repeated a sequence of amino acid residues (11–16, GAAILL) in positions 17–22 of the snake diagram.
Peishen eZhao +3 more
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Protease Activated Receptors and Arthritis. [PDF]
Int J Mol Sci, 2021 The catabolic and destructive activity of serine proteases in arthritic joints is well known; however, these enzymes can also signal pain and inflammation in joints. For example, thrombin, trypsin, tryptase, and neutrophil elastase cleave the extracellular N-terminus of a family of G protein-coupled receptors and the remaining tethered ligand sequence ...
Lucena F, McDougall JJ.
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Targeting Transient Receptor Potential (TRP) Channels, Mas-Related G-Protein-Coupled Receptors (Mrgprs), and Protease-Activated Receptors (PARs) to Relieve Itch [PDF]
Pharmaceuticals, 2023 Itch (pruritus) is a sensation in the skin that provokes the desire to scratch. The sensation of itch is mediated through a subclass of primary afferent sensory neurons, termed pruriceptors, which express molecular receptors that are activated by itch ...
Merab G. Tsagareli +3 more
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Zebrafish sperm outsource activation to eggs’ protease-activated receptors [PDF]
PLoS BiologyThe calcium surge that starts embryogenesis varies across species and is elusive in many. A new study in PLOS Biology shows that zebrafish eggs self-activate, initiating a protease-activated receptor calcium wave and uncovering a novel pathway in egg ...
Rafael A. Fissore +2 more
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Protease-activated receptors and inflammatory hyperalgesia [PDF]
Memorias do Instituto Oswaldo Cruz, 2005 Recent advances in basic science pointed to a role for proteinases, through the activation of proteinase-activated receptors (PARs) in nociceptive mechanisms.
Nathalie Vergnolle
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Protease-activated receptors in hemostasis. [PDF]
Blood, 2016 AbstractProtease signaling in cells elicits multiple physiologically important responses via protease-activated receptors (PARs). There are 4 members of this family of G-protein–coupled receptors (PAR1-4). PARs are activated by proteolysis of the N terminus to reveal a tethered ligand.
Nieman MT.
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Protease-activated receptors and itch. [PDF]
Handb Exp Pharmacol, 2015 Protease-activated receptors (PARs) have been implicated in a variety of physiological functions, as well as somatosensation and particularly itch and pain. Considerable attention has focused on PARs following the finding they are upregulated in the skin of atopic dermatitis patients.
Akiyama T, Lerner EA, Carstens E.
europepmc +4 more sources
Protease-Activated Receptors in the Intestine: Focus on Inflammation and Cancer [PDF]
Frontiers in Endocrinology, 2019 Protease-activated receptors (PARs) belong to the G protein-coupled receptor (GPCR) family. Compared to other GPCRs, the specificity of the four PARs is the lack of physiologically soluble ligands able to induce their activation.
Morgane Sébert +4 more
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