Results 21 to 30 of about 216,280 (242)
Journal of Diabetes Investigation, 2021 Aims/Introduction Thrombin exerts various pathophysiological functions by activating protease‐activated receptors (PARs). Recent data have shown that PARs influence the development of glomerular diseases including diabetic kidney disease (DKD) by ...
Tomoyo Hara +19 more
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Inhibition of Serine Proteases as a Novel Therapeutic Strategy for Abdominal Pain in IBS
Frontiers in Physiology, 2022 Serine proteases are heavily present in the gastrointestinal tract where they are essential in numerous physiological processes. An imbalance in the proteolytic activity is a central mechanism underlying abdominal pain in irritable bowel syndrome (IBS ...
Lisse Decraecker +2 more
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Targeting Platelet Thrombin Receptor Signaling to Prevent Thrombosis
Pharmaceuticals, 2013 Platelets contribute fundamentally to ischemic heart disease, and antiplatelet therapy has been critical to reducing acute thrombotic complications of atherosclerotic disease.
Susan S. Smyth, Eric L. Wallace
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Protease-Activated Receptors – Key Regulators of Inflammatory Bowel Diseases Progression
Journal of Inflammation Research, 2021 Damian Jacenik,1 Jakub Fichna,2 Ewa Małecka-Wojciesko,3 Anna Mokrowiecka3 1Department of Cytobiochemistry, Faculty of Biology and Environmental Protection, University of Lodz, Lodz, Poland; 2Department of Biochemistry, Faculty of Medicine, Medical
Jacenik D +3 more
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Dynamic allostery in thrombin—a review
Frontiers in Molecular Biosciences, 2023 Thrombin is a serine protease that catalyzes a large number of different reactions including proteolytic cleave of fibrinogen to make the fibrin clot (procoagulant activity), of the protease activated receptors (for cell signaling) and of protein C ...
Elizabeth A. Komives
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Gradient-dependent inhibition of stimulatory signaling from platelet G protein-coupled receptors
Haematologica, 2019 As platelet activation is an irreversible and potentially harmful event, platelet stimulatory signaling must be tightly regulated to ensure the filtering-out of inconsequential fluctuations of agonist concentrations in the vascular milieu.
Ankit S. Macwan +6 more
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Signal transduction by protease‐activated receptors [PDF]
British Journal of Pharmacology, 2010 The family of G protein‐coupled receptors (GPCRs) constitutes the largest class of signalling receptors in the human genome, controlling vast physiological responses and are the target of many drugs. After activation, GPCRs are rapidly desensitized by phosphorylation and β‐arrestin binding.
Unice J K, Soh +3 more
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Cells, 2021 Background: Protease-activated receptor 1 (PAR1) and toll-like receptors (TLRs) are inflammatory mediators contributing to atherogenesis and atherothrombosis.
Julian Friebel +18 more
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Assessment of neonatal, cord, and adult platelet granule trafficking and secretion
Platelets, 2020 Despite the transient hyporeactivity of neonatal platelets, full-term neonates do not display a bleeding tendency, suggesting potential compensatory mechanisms which allow for balanced and efficient neonatal hemostasis.
Anh T. P. Ngo +12 more
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Protease activated receptors: theme and variations [PDF]
Oncogene, 2001 The four PAR family members are G protein coupled receptors that are normally activated by proteolytic exposure of an occult tethered ligand. Three of the family members are thrombin receptors. The fourth (PAR2) is not activated by thrombin, but can be activated by other proteases, including trypsin, tryptase and Factor Xa.
O'Brien, Peter J +3 more
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