Results 11 to 20 of about 216,280 (242)

Protease-activated receptors in health and disease.

Physiol Rev, 2023
Proteases are signaling molecules that specifically control cellular functions by cleaving protease-activated receptors (PARs). The four known PARs are members of the large family of G protein-coupled receptors. These transmembrane receptors control most physiological and pathological processes and are the target of a large proportion of therapeutic ...
Peach CJ, Edgington-Mitchell LE, Bunnett NW, Schmidt BL.   +3 more
europepmc   +4 more sources

Proteases, Protease-Activated Receptors, and Atherosclerosis. [PDF]

Arterioscler Thromb Vasc Biol, 2018
Coagulation activation by the TF (tissue factor) pathway plays pivotal roles in triggering platelets and precipitating acute coronary syndromes. Although dual antiplatelet therapy is effective in secondary cardiovascular prevention, combining platelet antagonism with low-dose aspirin and the oral coagulation FXa antagonist rivaroxaban has a synergistic
Ruf W.
europepmc   +4 more sources

Protease-activated receptors (PARs): mechanisms of action and potential therapeutic modulators in PAR-driven inflammatory diseases [PDF]

Thrombosis Journal, 2019
Inflammatory diseases have become increasingly prevalent with industrialization. To address this, numerous anti-inflammatory agents and molecular targets have been considered in clinical trials. Among molecular targets, protease-activated receptors (PARs)
Dorothea M. Heuberger, Reto A. Schuepbach   +1 more
doaj   +2 more sources

Increased expression of protease-activated receptors 2 indicates poor prognosis in HBV related hepatocellular carcinoma [PDF]

Infectious Agents and Cancer, 2019
Objective To investigate the potential role of protease-activated receptor 2 (PAR2) in the prognosis of hepatocellular carcinoma (HCC). Methods A total of 202 HCC patients who underwent liver resections were included.
Peng Chen, Na Yang, Li Xu, Fangfang Zhao, Min Zhang   +4 more
doaj   +2 more sources

The protease-activated receptors are expressed in glioblastoma and differentially modulate adherent versus stem-like growth of LN-18 GBM cells [PDF]

Frontiers in Oncology
BackgroundGlioblastoma (GBM) remains the most aggressive and common malignant brain tumor in adults, often accompanied by venous thromboembolism due to hypercoagulability.
Sandra Bien-Möller, Sandra Bien-Möller, Antonia Grober, Judith Albrecht, Heiko Paland, Heiko Paland, Kerstin Weitmann, Angela Bialke, Sascha Marx, Silke Vogelgesang, Mladen V. Tzvetkov, Wolfgang Hoffmann, Henry W. S. Schroeder, Bernhard H. Rauch, Bernhard H. Rauch   +14 more
doaj   +2 more sources

Endosomal signaling by protease-activated receptors. [PDF]

Methods Enzymol, 2014
Protease-activated receptors (PARs) are a family of G protein-coupled receptors (GPCRs) that are uniquely activated by proteolysis. There are four members of the PAR family including: PAR1, PAR2, PAR3, and PAR4. PARs are expressed primarily in the cells of the vasculature and elicit cellular responses to coagulant and anticoagulant proteases.
Grimsey N, Lin H, Trejo J.
europepmc   +4 more sources

Protease-activated receptors in vascular smooth muscle cells: a bridge between thrombo-inflammation and vascular remodelling [PDF]

Cell Communication and Signaling
Coagulation factors are responsible for blood clot formation yet have also non-canonical functions as signalling molecules. In this context, they can activate protease-activated receptors (PARs) ubiquitously expressed in the vasculature.
Anxhela Habibi, Wolfram Ruf, Leon Schurgers   +2 more
doaj   +2 more sources

Determination of PAR4 numbers on the surface of human platelets: no effect of the single nucleotide polymorphism rs773902

Platelets, 2021
The thrombin receptor, protease-activated receptor 4 (PAR4), is important for platelet activation and is the target of emerging anti-thrombotic drugs. A frequently occurring single nucleotide polymorphism (SNP; rs773902) causes a function-altering PAR4 ...
Simeng Li, Volga Tarlac, Roberto B. I. Christanto, Shauna L. French, Justin R. Hamilton   +4 more
doaj   +1 more source

Protease‐activated receptors and myocardial infarction [PDF]

IUBMB Life, 2011
AbstractProtease‐activated receptors (PARs) are widely expressed within the heart. They are activated by a myriad of proteases, including coagulation proteases. In vitro studies showed that activation of PAR‐1 and PAR‐2 on cardiomyocytes induced hypertrophy. In addition, PAR‐1 stimulation on cardiac fibroblasts induced proliferation.
Silvio, Antoniak, Rafal, Pawlinski, Nigel, Mackman   +2 more
openaire   +2 more sources

Cardiac Expression of Factor X Mediates Cardiac Hypertrophy and Fibrosis in Pressure Overload

JACC: Basic to Translational Science, 2020
Summary: Activated factor X is a key component of the coagulation cascade, but whether it directly regulates pathological cardiac remodeling is unclear.
Xinji Guo, PhD, Mikhail A. Kolpakov, MD, PhD, Bahman Hooshdaran, PhD, William Schappell, BS, Tao Wang, MD, PhD, Satoru Eguchi, MD, PhD, Katherine J. Elliott, PhD, Douglas G. Tilley, PhD, A. Koneti Rao, MD, Patricia Andrade-Gordon, PhD, Matthew Bunce, PhD, Chintala Madhu, PhD, Steven R. Houser, PhD, Abdelkarim Sabri, PhD   +13 more
doaj   +1 more source