Results 31 to 40 of about 216,280 (242)
, 2003 Publisher Summary Distinct proteases—best exemplified by serine proteases such as thrombin—are potent cellular activators. Many of these cellular effects are mediated by a group of seven transmembrane G-protein-coupled receptors, uniquely activated by proteolytic cleavage [protease-activated receptors (PARs)].
openaire +4 more sources
Diversification of PAR signaling through receptor crosstalk
Cellular & Molecular Biology Letters, 2022 Protease activated receptors (PARs) are among the first receptors shown to transactivate other receptors: noticeably, these interactions are not limited to members of the same family, but involve receptors as diverse as receptor kinases, prostanoid ...
Irene Lee-Rivera +2 more
doaj +1 more source
Trypsin, Tryptase, and Thrombin Polarize Macrophages towards a Pro-Fibrotic M2a Phenotype.
PLoS ONE, 2015 For both wound healing and the formation of a fibrotic lesion, circulating monocytes enter the tissue and differentiate into fibroblast-like cells called fibrocytes and pro-fibrotic M2a macrophages, which together with fibroblasts form scar tissue ...
Michael J V White, Richard H Gomer
doaj +1 more source
Protease-Activated Receptors in Cardiovascular Diseases [PDF]
Circulation, 2006 Thrombosis associated with the pathophysiological activation of platelets and vascular cells has brought thrombin and its receptors to the forefront of cardiovascular medicine. Thrombin signaling through the protease-activated receptors (PARs) has been shown to influence a wide range of physiological responses including platelet activation, intimal ...
Andrew J, Leger +2 more
openaire +2 more sources
Thrombin-Induced Calpain Activation Promotes Protease-Activated Receptor 1 Internalization
International Journal of Cell Biology, 2017 The serine protease thrombin activates Protease-Activated Receptors (PARs), a family of G-protein-coupled receptors (GPCRs) activated by the proteolytic cleavage of their extracellular N-terminal domain.
Alejandro Alvarez-Arce +4 more
doaj +1 more source
Protease activated receptors 1 and 4 sensitize TRPV1 in nociceptive neurones
Molecular Pain, 2010 Protease-activated receptors (PAR1-4) are activated by proteases released by cell damage or blood clotting, and are known to be involved in promoting pain and hyperalgesia.
Magherini Pier C +7 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Platelets, 2017 Thrombin is the most potent agonist of human platelets and its effects are primarily mediated through the protease-activated receptors (PARs)-1 and -4.
I. C. Moschonas +7 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Activity of protease-activated receptors in primary cultured human myenteric neurons
Frontiers in Neuroscience, 2012 Activity of the four known protease-activated receptors (PARs) has been well studied in rodent enteric nervous system and results in animal models established an important role for neuronal PAR2.
Eva Maria Kugler +5 more
doaj +1 more source